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The PSTP currently consists of a mix of interns, residents and fellows of all different levels and subspecialities. The current subspecialty matrix crosses the areas of hematology-oncology, gastrointerology, endocrinology, rheumatology, infectious diseases and pulmonary critical care medicine.

In past years graduates of the PSTP have, by and large, pursued academic medical careers in a variety of areas, including the National Institutes of Health.

PSTP Residents


  • Harrison Penrose, MD, PhD
  • Eric Roth, MD, PhD
  • Amara Seng, MD, PhD


  • Morgan Birabaharan, MD
  • Brian Ji, MD, PhD


  • Michael Doud, MD, PhD


  • Sharon Choi, MD, PhD
  • Cynthia Hsu, MD, PhD
  • Paul Hsu, MD, PhD


  • Sydney Ramirez, MD, PhD
  • Shiruyeh Schokrpur, MD, PhD


  • Benjamin Goldenson, MD, PhD      
  • Kentson Lam, MD, PhD
  • NAME

    Kentson Lam, MD, PhD
    School: UC San Diego
    Division: Hematology-Oncology


  • Calvin Hang, MD, PhD
  • NAME

    Calvin Hang, MD, PhD
    School: UC San Diego
    Division: Cardiology
    Mentor:Neil Chi, MD

  • Thomas Martin, MD, MS
  • NAME

    Thomas Martin, MD, MS
    School: University of Oxford
    Division: Infectious Diseases
    Mentor: Dr. Patricia Liao

  • Thomas Prohaska, MD
  • NAME

    Thomas Prohaska, MD
    School: Medical University of Vienna
    Division: Cardiology
    Mentors: Dr. Joe Witztum

  • Stephen Rawlings, MD, PhD
  • NAME

    Stephen Rawlings, MD, PhD
    School: New York University
    Division: Infectious Diseases
    Mentor: Dr. Darcy Wooten


  • Sarah Burgdorf, MD, PhD
  • NAME

    Sarah Burgdorf, MD, PhD
    School: UC San Diego
    Division: Infectious Diseases

  • Michael Lam, MD, PhD
  • NAME

    Michael Lam, MD, PhD
    School: UC San Diego 
    Division: Pulmonary and Critical Care Medicine

  • Darius Schneider, MD, PhD (Transferred to UW)
  • Matthew Tsai, MD, PhD 
  • NAME

    Matthew Tsai, MD, PhD
    School: University of Miami
    Division: Gastroenterology


  • Sudeb Dalai, MD, PhD (Infectious Diseases; Transferred to Stanford)
  • Adam Greenbaum, MD, PhD (Hematology-Oncology; Transferred to UW)


  • Calvin Yeang, MD, PhD
  • Kay Yeung, MD, PhD
  • Kay Yeung

    Dr. Yeung is a recent graduate of New York University School of Medicine. She received her undergraduate degree from Binghamton University in 2002, where she studied biochemistry.

    She is a third-year fellow in hematology-oncology.

    Selected Publications

    Yeung K, Yang J. Epithelial-mesenchymal transition in tumor metastasis. Mol Oncol. 2017 Jan; 11(1):28-39. PMID: 28085222.

    Yeung K, Cohen EE. Lenvatinib in Advanced, Radioactive Iodine-Refractory, Differentiated Thyroid Carcinoma. Clin Cancer Res. 2015 Dec 15; 21(24):5420-6. PMID: 26487760.

    Das S, Yeung K, Mahajan MA, Samuels HH. Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain. BMC Cancer. 2014; 14(1):852. PMID: 25409762.

    Yeung K, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH. A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2. Mol Cell Biol. 2011 Jun; 31(11):2287-98. PMID: 21444724.

    Tinnikov AA, Yeung K, Das S, Samuels HH. Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells. Cancer Res. 2009 Feb 15; 69(4):1375-82. PMID: 19190336.

    Yasmin R, Yeung K, Chung RH, Gaczynska ME, Osmulski PA, Noy N. DNA-looping by RXR tetramers permits transcriptional regulation "at a distance". J Mol Biol. 2004 Oct 15; 343(2):327-38. PMID: 15451664.


  • Edwin Yau, MD, PhD
  • Edwin Yau

    Dr. Yau graduated from the University at Buffalo State University of New York School of Medicine & Biomedical Sciences in 2011. His undergraduate studies were completed at Johns Hopkins University in Baltimore, Maryland.

    Selected Publications

    Abdelmaksoud HE, Yau EH, Zuker M, and Sullivan JM. Development of Lead Hammerhead Ribozyme Candidates against Human Rod Opsin for Retinal Degeneration Therapy. Exp Eye Res.2009 May; 88(5): 859-879. Cited in PubMed; PMID: 19094986.

    Kolniak T, Yau E, Taggart R, and Sullivan JM. Identification of Lead Candidate Ribozymes for Human Rod Opsin Therapeutics. Invest. Ophthalmol. Vis. Sci..2007 May; 48(Abstract): 1682.

    Kolniak T, Yau EH, Butler MC, and Sullivan JM. Cellular Toxicity Screening of Candidate Therapeutic Ribozyme Chimeras. Invest. Ophthalmol. Vis. Sci..2008 Apr; 49(Abstract): 1699.

    Kolniak TA, Butler MC, Taggart RT, Yau EH, Benz R, Fliesler SJ, and Sullivan JM. A Novel Fully Humanized RHO
    adRP Mouse Model. Invest. Ophthalmol. Vis. Sci..2010 May; 51(Abstract): 4071.

    Kolniak TA, Yau EH, and Sullivan JM. Modifications to Adenoviral VAI RNA as a Cytoplasmic Carrier for Post-
    Transcriptional Gene Silencing Agents. Invest. Ophthalmol. Vis. Sci..2009 May; 50(Abstract): 3018.

    Sullivan JM and Yau EH. Human-Directed RNA Drug Discovery - Are Animal mRNA Targets Suitable
    Representatives?. Invest. Ophthalmol. Vis. Sci..2009 May; 50(Abstract): 3016.

    Sullivan JM, Yau EH, Taggart RT, Butler MC, and Kolniak TA. Bottlenecks in development of retinal therapeutic posttranscriptional gene silencing agents. Vis Res.2008 Feb; 48(3): 453-469. Cited in PubMed; PMID: 17976683.

  • Adam Burgoyne, MD, PhD
  • Adam Burgoyne

    Dr. Burgoyne is a recent graduate from Case Western Reserve University School of Medicine. He received his undergraduate degree from the University of Maine in 2004, where he studied Molecular and Cellular Biology, Biochemistry and French.

    Selected Publications

    Burden-Gulley SM, Gates TJ, Burgoyne AM, Cutter JL, Lodowski DT, Robinson S, Sloan AE, Miller RH, Basilion JP, and Brady-Kalnay SM. A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase mu. Neoplasia.2010 Apr; 12(4): 305-316. Cited in PubMed; PMID: 20360941.

    Burgoyne AM, Palomo JM, Phillips-Mason PJ, Burden-Gulley SM, Major DL, Zaremba A, Robinson S, Sloan AE,
    Vogelbaum MA, Miller RH, and Brady-Kalnay SM. PTPmu suppresses glioma cell migration and dispersal. Neuro Oncology.2009 Dec; 11(6): 767-778. Cited in PubMed; PMID: 19304959.

    Burgoyne AM, Phillips-Mason PJ, Burden-Gulley SM, Robinson S, Sloan AE, Miller RH, and Brady-Kalnay SM.
    Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. Cancer Research.2009 Sep; 69(17): 6960-6968. Cited in PubMed; PMID: 19690139.

    Ekborg NA, Morrill W, Burgoyne AM, Li L, and Distel DL. CelAB, a multifunctional cellulase encoded by Teredinibacter turnerae T7902T, a culturable symbiont isolated from the wood-boring marine bivalve Lyrodus pedicellatus. Applied and Environmental Microbiology.2007 Dec; 73(23): 7785-7788. Cited in PubMed; PMID: 17933945.


  • Jennifer Dan, MD, PhD
  • Jennifer Dan

    Dr. Jennifer Dan graduated from Boston University combined MD/PhD program. I received my Ph.D. in the Department of Microbiology/Immunology Training Program where I worked on vaccine development for Crytococcus neoformans in Dr. Stuart Levitz's laboratory. Prior to this, I received my B.A. in Classics and B.S. in Biochemistry from the University of Tennessee, Knoxville. I am currently a PGY-2 resident and will be pursuing my fellowship in infectious diseases.

    Selected Publications

    Dan J.M. and Levitz, S.M. Prospects for development of vaccines against fungal diseases. Drug Resistance Updates. 2006; 9(3):105-10.

    Specht C.A., Nong S., Dan J.M., Lee C.K., and Levitz, S.M. Contribution of glycosylation to T-cell responses stimulated by recombinant Cryptococcus neoformans mannoprotein. Journal of Infectious Disease. 2007; 196(5); 796-800.

    Dan J.M., Wang, J.P., Lee, C.K., and Levitz, S.M. Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides. PLoS ONE. 2008; 3 (4); e2046.

    Dan, J.M., Kelly, R.M., Lee, C.K., and Levitz, S.M. The Role of the Mannose Receptor in a Murine Model of Cryptococcus neoformans Infection. Infection and Immunity. 2008; 76(6): 2362-2367.

    Dan, J.M., Agarwal, S, Burke P, Majoney E.J. Adult Intussusception Secondary to Colorectal Cancer in a Young Man: A Case Report. J Emerg Med. 2011; Epub ahead of print.

  • Aaron Miller, MD, PhD 


  • Lawrence Ang, MD  
  • Lawrence Ang

    Dr. Lawrence Ang is a graduate of the UC San Diego Medical Scholars Program receiving his bachelor’s degree magna cum laude in biochemistry and cell biology in 2005 and medical degree in 2009. He spent a year studying abroad at Peking University (Beijing, China) and Yonsei Univeristy (Seoul, Korea) before returning to UC San Diego and completing his medical education. He is currently a cardiology fellow working with Dr. Ehtisham Mahmud in the cardiovascular catheterization laboratories with a research interest in antiplatelet therapies and cardiovascular interventions.

    Selected Publications

    Zhou JQ, Choe E, Ang L, Schnittger I, Rockson SG, Tremmel JA, Haddad F. Stress-induced cardiomyopathy associated with a transfusion reaction: A case of potential crosstalk between the histaminic and adrenergic systems. Exp Clin Cardiol 2011;16:30-2.

    Ang L, Palakodeti V, Khalid A, Tsimikas S, Idrees Z, Tran P, Clopton P, Zafar N, Bromberg-Marin G, Keramati S, Mahmud E. Elevated plasma fibrinogen and diabetes are associated with lower inhibition of platelet reactivity with clopidogrel. J Am Coll Cardiol 2008;52:1052-9.

    Ang L, Mahmud E. Monitoring oral antiplatlelet therapy: is it justified? Ther Adv Cardiovasc Dis 2008;2:485-96.

    Mahmud E, Bromberg-Marin G, Palakodeti V, Ang L, Creanga D, DeMaria AN. Clinical efficacy of drug eluting stents in diabetic patients: a meta-analysis. J Am Coll Cardiol 2008;51:2385-95.

    Mahmud E, Smith T, Palakodeti V, Zaidi O, Ang L, Mitchell R, Zafar N, Bromberg-Marin G, Keramati S, Tsimikas S. Renal frame count and renal blush grade: quantitative measures that predict the success of renal stenting in hypertensive patients with renal artery stenosis. J Am Coll Cardiol Intv 2008;1:286-292.

    Mahmud E, Cavendish JJ, Tsimikas S, Ang L, Nguyen C, Bromberg-Marin G, Schnyder G, Keramati S, Palakodeti V, Penny WF, DeMaria AN. Elevated plasma fibrinogen level predicts suboptimal response to therapy with both single- and double-bolus eptifibatide during percutaneous coronary intervention. J Am Coll Cardiol 2007;49:2163-71.

    Mahmud E. Ang L. Monitoring antiplatelet therapy during peripheral vascular and coronary interventions. Tech Vasc Interv Radiol 2006;9:56-63.

  • Aaron Carlin, MD, PhD
  • Aaron Carlin

    Aaron Carlin graduated from the University of California, San Diego, receiving his Ph.D. in 2007 and his medical degree in 2009. He performed his undergraduate ​work at the University of California, Los Angeles.

    Selected Publications

    Carlin AF, Lewis AL, Varki A, Nizet V. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.. Journal of Bacteriology.2007 Feb; 189(4): 1231-1237. Cited in PubMed; PMID: 16997964.

    Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V.. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus.. Journal of BiologicalChemistry.2007 Sep; 282(38): 27562-27571. Cited in PubMed; PMID: 17646166.

  • Christopher Larson, MD, PhD
  • Christopher Larson

    Chris Larson graduated from the University of Texas, Southwestern Medical School at Dallas in 2009. He performed his undergraduate studies at the University of Houston.

    Selected Publications

    Shulman A, Larson C, Mangelsdorf D, Ranganathan R. Structural determinants of allosteric ligand activation in RXR heterodimers.. Cell.2004 Feb; 116(3): 417-429. Cited in PubMed; PMID: 15016376.

    Swint-Kruse L, Larson C, Pettitt B, Matthews K. Fine-tuning function: correlation of hinge domain interactions with functional distinctions between LacI and PurR.. Protein Science.2002 Apr; 11(4): 269-273. Cited in PubMed; PMID: 11910022.


  • Brigid Boland, MD
  • Mary Lewinski, MD, PhD 
  • Mary Lewinski

    Dr. Mary Lewinski earned her M.D. and Ph.D. as part of the MSTP at UC-San Diego. For her Ph.D. in Biomedical Sciences she studied retroviral integration at the Salk Institute with Frederic Bushman, Ph.D. Prior to this, she graduated from the University of Southern California in 2000 with a B.A. in Philosophy and a B.A. in Political Science. She is currently an Infectious Diseases fellow working with John Guatelli, M.D. at the UCSD Center for AIDS Research.

    Selected Publications

    M. K. Lewinski, M. Yamashita, M. Emerman, A. Ciuffi, H. Marshall, G. Crawford, F. Collins, P. Shinn, J. Leipzig, S. Hannenhalli, C. C. Berry, J. R. Ecker, F. D. Bushman. “Retroviral DNA integration: viral and cellular determinants of target-site selection,” PLoS Pathogens, 2 (6), June 2006, p. e60.

    F. Bushman, M. K. Lewinski, A. Ciuffi, S. Barr, J. Leipzig, S. Hannenhalli, C. Hoffmann. “Genome-wide analysis of retroviral DNA integration,” Nature Reviews Microbiology, 3 (11), November 2005, p. 848-858.

    D. Bisgrove, M. Lewinski, F. Bushman, E. Verdin. “Molecular mechanisms of HIV-1 proviral latency,” Expert Review of Anti-infective Therapy, 3 (5), October 2005, p. 805-814.

    M. K. Lewinski and F. D. Bushman. “Retroviral DNA Integration—Mechanism and Consequences,” Advances in Genetics, 55, 2005, p. 147-181.

    M. K. Lewinski, D. Bisgrove, P. Shinn, H. Chen, C. Hoffmann, S.Hannenhalli, E. Verdin, C. C. Berry, J. R. Ecker, and F. D. Bushman. “Genome-Wide Analysis of Chromosomal Features Repressing Human Immunodeficiency Virus Transcription,” Journal of Virology, 79 (11), June 2005, p. 6610-6619.

  • Anna Narezkina, MD, PhD
  • Anna Narezkina

    Dr. Anna Narezkina graduated summa cum laude from Smolensk State Medical Academy, one of the largest medical, research and educational centers in Russia. Starting from the second year of medical school Dr. Narezkina has worked in the Institute of Antimicrobial Chemotherapy on the molecular mechanisms of antibiotic resistance of nosocomial pathogens. After the fourth year of a six-year medical school program she came to Fox Chase Cancer Center (Philadelphia, PA) to Dr. Ann Skalka’s lab where she was studying molecular mechanisms of retroviral DNA integration. Dr. Narezkina is currently a fellow in Cardiology and she is working at Dr. Knowlton’s lab on the effects of miRNA-146a on the pathogenesis of Coxsackievirus infection.

    Selected Publications

    Narezkina A, Taganov K, Litwin S, Stoyanova R, Hayashi J, Seeger C, Skalka AM and Katz R. Genome-wide analyses of Avian sarcoma virus integration sites in human DNA. Journal of Virology. 2004, Nov; 78(21):11656-63. Cited in PubMed; PMID: 15479807. Pub Status: Published.

    Stratchounski LS, Dekhnich AV, Kretchikov VA, Edelstain IA, Narezkina A, Afinogenov GE, Akhmetova LI, Boronina LG, Gugutcidze EN, Gudkova LV, Zdzitovetcki DE, Ilyina VN, Kretchikova OI, Marusina NE, Multih IG, Pylaeva SI, Smirnov IV, Suborova TN. Antimicrobial resistance of nosocomial strains of Staphylococcus aureus in Russia: results of a prospective study. Journal of Chemotherapy. 2005, Feb; 17(1):54-60. Cited in PubMed; PMID: 15828444. Pub Status: Published.

    Narezkina A. New antiviral defence guard (article in Russian). Clinical microbiology and antimicrobial chemotherapy. 2005, Apr; 7(2):112-118. Pub Status: Published.

    Katz RA, Jack-Scott E, Narezkina A, Palagin I, Boimel P, Kulkosky J, Nicolas E, Greger JG, Skalka AM. High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. Journal of Virology. 2007, Mar; 81(6):2592-604. Cited in PubMed; PMID: 17202206. Pub Status: Published.

  • JP Shen, MD
  • JP Shen

    John Paul Shen is a native of St. Louis, MO, and remains a dedicated supporter of the St. Louis Cardinals. He studied chemistry at the Massachusetts Institute of Technology, graduating in 2002 with selection to the Phi Beta Kappa honor society. Dr. Shen completed his medical education at Washington University in St. Louis, taking one year off to participate in a Howard Hughes Medical Institute research fellowship at the Broad Institute of Harvard and MIT under the direction of Drs. Stuart Schreiber and James Bradner. Currently a second-year fellow in hematology and oncology, Dr. Shen is now working in the laboratory of Dr. Trey Ideker. His research interests include cancer biology with a focus on identifying new chemotherapeutic targets and the development of novel chemotherapeutic compounds.

    Selected Publications

    Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Chemical genetic strategy identifies HDAC1 ad HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci. July 2010; 107 (28) 12617-22. PMID: 20616024

    Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. A robust small-molecule microarray platform for screening cell lysates. Chem Biol. May 2006; 5 (5) 493-504. PMID: 16720270

    Shen JP, Divakaran S, Ponduro S, Vogl DT, Amaravadi RK, Bradner JE. The rational for combined proteasome and autophagy inhibition in multiple myeloma established using novel translational platforms. Blood (ASH Annual Meeting Abstracts). Nov 2008; 112: 2755

    Shen JP, Divakaran S, Kuai LT, Wang X, Ong SE, Amaravadi R, Wood J, Carr S, Haggarty S, Bradner JE. Autophagy as a Target Pathway in Multiple Myeloma: a Forward Chemical Genetic Approach. Blood (ASH Annual Meeting Abstracts). Nov 2007; 110 (11) 2510.

    Shen JP, Greenberg EF, Hideshima T, Anderson KC, Schreiber SL, Bradner JE. Targeting the Protein Degradation Pathway in Multiple Myeloma with Synergistic, Selective Small Molecules. Blood (ASH Annual Meeting Abstracts). Nov 2005; 106 (11) 2471.

  • Amir Zarrinpar, MD, PhD 
  • Amin Zarrinpar, MD, PhDPrincipal Investigator. AB Psychology and Biology. PhD Neurosciences. MD Internal Medicine, Fellowship in Gastroenterology and Hepatology, Post-doctoral work in Circadian Rhythms, Metabolism, and Gut Microbiome. Enjoys the golden age of television, griping about the LA (?!?) Chargers, and spending time with his wife and kids.

    Selected Publications

    Percutaneous Gastrostomy Device for the Treatment of Class II and Class III Obesity: Results of a Randomized Controlled Trial.
    Author(s): Thompson, C.C., Abu Dayyeh, B.K., Kushner, R., Sullivan, S., Schorr, A.B., Amaro, A., Apovian, C.M., Fullum, T., Zarrinpar, A., Jensen, M,D., Stein, A.C., Edmundowicz, S., Kahaleh, M., Ryou, M., Bohning, J.M., Ginsberg, G., Huang, C., Tran, D.D., Glaser, J.P., Martin, J.A., Jaffe, D.L., Farraye, F.A., Ho, S.B., Kumar, N., Harakal, D., Young, M., Thomas, C.E., Shukla, A.P., Ryan, M.B., Haas, M., Goldsmith, H., McCrea, J., Aronne, L.J.
    Source: American Journal of Gastroenterology [Epub ahead of time]
    Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes.
    Author(s): Singh, S., Dulai, P.S., Zarrinpar, A., Ramamoorthy, S., Sandborn, W.J.
    Source: Nature Reviews Gastroenterology & Hepatology 14:110-121
    The circadian coordination of cell biology.
    Author(s): Chaix, A., Zarrinpar, A., Panda, S.
    Source: Journal of Cell Biology 215:15-25
    Treating Obesity and Metabolic Syndrome with Fecal Microbiota Transplantation.
    Author(s): Marotz, C.A., Zarrinpar, A.
    Source: Yale Journal of Biology and Medicine 89: 383-8
    Daily Eating Patterns and Their Impact on Health and Disease.
    Author(s): Zarrinpar, A., Chaix, A., and Panda, S.
    Source: Trends in endocrinology and metabolism: TEM 27:69-83
    Targeting Dysbiosis for the Treatment of Liver Disease.
    Author(s): Anand, G., Zarrinpar, A., and Loomba, R.
    Source: Seminars in Liver Disease 36: 37-47
    Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study.
    Author(s): Zarrinpar, A., Gupta, S., Maurya, M.R., Subramaniam, S., and Loomba, R.
    Source: Gut 65: 1546-1554
    Functional Local Input to Layer 5 Pyramidal Neurons in the Rat Visual Cortex.
    Author(s): Zarrinpar, A., and Callaway, E.M.
    Source: Cerebral Cortex 26: 991-1003 


  • Julio Anacleto Gutierrez, MS, MD 
  • Dr. Gutierrez earned an undergraduate degree in Integrative Biology from University of California at Berkeley, a Master of Science from Columbia University and his MD from Mount Sinai School of Medicine in New York City. Dr. Gutierrez took the unusual path of undertaking a significant amount of research while at the same time completing his medical education uninterrupted. At Mount Sinai, Dr. Gutierrez worked with Dr. Andrea Branch studying the hepatitis C virus (HCV), using tools from bioinformatics, classical virology, molecular biology and translational research. The main focus of his research was identifying the natural history of the Alternate Reading Frame Protein in HCV, the humoral immune response to HCV proteins, and affinity purification of anti-HCV antibodies from ascitic fluid.

    Dr. Gutierrez completed his training in Internal Medicine in 2009 at UCSD and is a Gastroenterology T32 Fellow until 2012. He joined the laboratory of Drs. Robert “Chip” Schooley and David Wyles where he continues to study HCV. He is the principal investigator of an IRB approved serum and tissue for chronic liver disease and co-investigator on two active grants. Currently, his research attempts to understand how vitamin D inhibits HCV in vitro. Additionally, he is conducting pilot studies of vitamin D supplementation measuring HCV viral kinetics. Another area of focus of Dr. Gutierrez’s research is to develop methods for ultra-deep sequencing in HCV. He is applying this technology to regions of HCV associated with hepatocellular carcinoma and resistance to direct acting antivirals against HCV. Dr. Gutierrez’s main clinical interest is in HCV and liver transplantation.

    His awards and honors include the National Medical Fellowship, New York Academy of Medicine Louis Seaman Grant, Gelernt Award for Academic Excellence and Community Service, and Distinguished Fellow of the NACGF. He is a current co-investigator on a CFAR pilot project to characterize HCV mutations associated with hepatocellular carcinoma and a diversity supplement for Ms. Roxana Flores for ultra-deep sequencing of HCV mutations related to resistance of direct acting antivirals in HCV.

    Selected Publications

    Walewski, J.L., Gutierrez, J.A., Branch-Elliman, W., Stump, D.D., Keller, T.R., Rodriguez, A., Benson, G. & Branch, A.D. 2002, "Mutation Master: profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions", RNA (New York, N.Y.), vol. 8, no. 5, pp. 557-571.

    Branch, A.D., Stump, D.D., Gutierrez, J.A., Eng, F. & Walewski, J.L. 2005, "The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others", Seminars in liver disease, vol. 25, no. 1, pp. 105-117.

    Lawal, A., Basler, C., Branch, A., Gutierrez, J., Schwartz, M. & Schiano, T.D. 2004, "Influenza vaccination in orthotopic liver transplant recipients: absence of post administration ALT elevation", American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 4, no. 11, pp. 1805-1809.

    Schiano, T.D., Gutierrez, J.A., Walewski, J.L., Fiel, M.I., Cheng, B., Bodenheimer, H.,Jr, Thung, S.N., Chung, R.T., Schwartz, M.E., Bodian, C. & Branch, A.D. 2005, "Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors", Hepatology, vol. 42, no. 6, pp. 1420-1428.

    Stanca, C.M., Bach, N., Krause, C., Tandon, N., Freni, M.A., Gutierrez, J.A., Bodian, C., Lopez, J., Berk, P.D., Bodenheimer, H.C.,Jr, Branch, A.D. & Odin, J.A. 2005, "Evaluation of fatigue in U.S. patients with primary biliary cirrhosis", The American Journal of Gastroenterology, vol. 100, no. 5, pp. 1104-1109.

    Hytiroglou, P., Gutierrez, J.A., Freni, M., Odin, J.A., Stanca, C.M., Merati, S., Schiano, T.D., Branch, A.D. & Thung, S.N. 2009, "Recurrence of primary biliary cirrhosis and development of autoimmune hepatitis after liver transplant: A blind histologic study", Hepatology research : the official journal of the Japan Society of Hepatology, vol. 39, no. 6, pp. 577-584.

    Childs, K.E., Fishman, S.L., Constable, C., Gutierrez, J.A.,Wyatt, C.M., Dieterich, D.T., Mullen, M.P., & Branch, A.D. 2010, “Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users”, AIDS Res Hum Retroviruses. Vol. 8: pp. 855-9.

    Gutierrez, J.A., Klepper, A., Garber, J., Walewski, J.L., Bateman, K., Khaitova, V., Syder, A., Tscherne, D.M., Gauthier, A., Jefferson, D., Rice, C.M., Schiano, T,D., & Branch, A.D. 2010, “Cross-genotypic polyclonal anti-HCV antibodies from human ascitic fluid”, J Virol Methods. J Virol Methods. 2011 Jan;171(1):169-75.

    Chang, T.L., Klepper, A., Ding, J., Garber, J., Rapista, A., Mosoian, A., Hubner, W., Gutierrez, J.A., Walewski, J., Abergel, J., Schiano, T. & Branch, A. 2010, "Human Peritoneal Macrophages From Ascitic Fluid Can be Infected by a Broad Range of Human Immunodeficiency Virus Type 1 Isolates", Journal of acquired immune deficiency syndromes. Vol. 53, no. 3, pp. 292-302.

    Gutierrez J.A., Patton H., “HCV and ESRD.” Curent Hepatitis Reports. In Publication. June 2011.

    Gutierrez, J.A., Jones, K.A., Fitzgerald, R.L., Branch, A.D., Schooley, R.T., & Wyles, D.L., “Vitamin D metabolites inhibit replication the hepatitis C virus”, 2011, In preparation for Hepatology.

    Gutierrez J.A., Branch A.D., “Vitamin D and HCV.” Seminars in Liver Disease. Invited Manuscript in Preparation. August 2011.

  • Frederick Park, MD, PhD 
  • Fred Park

    Dr. Park graduated magna cum laude from Princeton University in 1995, where his research toward developing novel mass spectrometry techniques was awarded outstanding undergraduate research awards by Sigma Xi and the American Cyanamid Corp. He then entered the Medical Scientist Training Program at the University of Washington and received his PhD in Molecular and Cellular Biology in 2004 and his MD in 2006. He has been awarded grants from the Cora May Poncin Foundation and the University of Washington for research on the establishment and propagation of polarity in developing embryonic cells and tissues. He is currently a first-year resident and he will pursue his fellowship training in gastroenterology.

    Selected Publications

    Park, F. D., Tenlen, J. R., and Priess, J. R. (2004) C. elegans MOM-5/Frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division. Current Biology 14: 2252-2258.

    Park, F. D. and Priess, J. R. (2003) Establishment of POP-1 asymmetry in early C. elegans embryos. Development 130: 3547-3556.

    Hayward, M. J., Park, F. D., Manzella, L. M., and Bernasek, S. L. (1995) Sputtered protons during surface-induced dissociation (SID) tandem mass spectrometry (MS/MS). Int. J. Mass Spectrometry and Ion Processes 148: 25-30.


  • Eliah Aronoff-Spencer, MD, PhD 
  • Eliah Aronoff-Spencer

    Dr. Eliah Aronoff-Spencer joined the PSTP after graduating from Albert Einstein College of Medicine with clinical as well as research honors. His research has ranged from structural biophysics and biology applied to neurotoxic proteins such as prions and the Beta-amyloid protein, to computer modeling and simulation. He spent a year of practicing international medicine and is currently a faculty member in the division of infectious diseases, working in medical decision making theory as well as developing "need" based research efforts- bringing international medical problems to basic medical and science researchers to drive scientific efforts at UC San Diego and abroad.

  • William Go, MD, PhD 
  • William Go

    Dr. Go graduated magna cum laude and received his Phi Beta Kappa, Sigma Xi from Carleton College in 1998. He then entered the Medical Scientist Training Program at UC San Diego and received his PhD in biomedical sciences with a focus in immunology in 2004 and his MD in 2006. He has been awarded grants from the Stein Institute for Research on Aging and the Glenn/American Federation for Aging Research. Dr. Go's research has been the study of transcriptional regulation of T cells in both in vitro and in vivo models. He is currently a first year resident and he will pursue his fellowship training in hematology-oncology.

    Selected Publications

    Li, S.Z., McDill, B.W., Kovach, P.A., Ding, L., Go, W.Y., Ho, S.N. Chen, F. Calcineurin/NFATc and TonEBP/NFAT5 regulate AQP2 expression in response to osmotic change. Manuscript in preparation to be submitted 2006.

    Park, S.H., Kim, D.J., Jeon, U.S., Go, W.Y., Ho, S.N., Woo, S.K. and Kwon, H.M. 2004. Urinary concentration defect in TonEBP +/- mice. American Society of Nephrology Meeting.

    Go, W.Y., Liu, X., Roti, M.A., Liu, F., and Ho, S.N. 2004. NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proceedings of the National Academy of Science. 101(29):10673-8.

    Lu, Q., Liu, X., Trama, J., Roti, M. A., Go, W.Y., and Ho, S.N. 2004. Identification of the cytoskeletal regulatory protein a-adducin as a target of T cell receptor signaling. Molecular Immunology. 41(4): 435-447.

    Trama, J., Go, W.Y., Ho S.N. 2002. The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. Journal of Immunology. 169(10):5477-5488.

    Go, W.Y., Ho S.N. 2002. Optimization and direct comparison of the dimerizer and reverse tet transcriptional control systems. Journal of Gene Medicine. 4(3):258-270.

    Takeda, T., Go, W.Y., Orlando, R.A., Farquhar, M.G. 2000. Expression of podocalyxin inhibits cell-cell adhesion and modifies properties in Madin-Darby Canine Kidney Cells. Molecular Biology of the Cell. 11(9): 3219-3232.

    Go, W.Y., Holicky, E.L., Hadac, E.M., Rao, R.V., Miller, L.J. 1998. Identification of a domain in the carboxy terminus of CCK receptor that affects its intracellular trafficking. American Journal of Physiology. 275(1 Pt 1):G56-62.

    Go, W.Y., Roettger, B.F., Holicky, E.L., Hadac, E.M., Miller, L.J. 1997. Quantitative dynamic multicompartmental analysis of cholecystokinin receptor movement in a living cell using dual fluorophores and reconstruction of confocal images. Analytical Biochemistry. 247(2):210-215.

  • Matthew Husa, MD 
  • Matthew Husa

    Matt Husa, MD, is a first year rheumatology fellow. He graduated from Mt. Sinai School of Medicine of New York University after completing the HHMI-NIH Research Scholars Program. His research interests center on chondrocyte biology relating to redox stress and the pathophysiology of osteoarthritis. He is pursuing these interests via full-time research in the laboratory of Robert Terkeltaub, MD, in the Division of Rheumatology, Allergy and Immunology.

    Selected Publications

    Pesu M, Candottie F, Husa M, Hofmann SR, Notarangelo LD, O'Shea JJ. Jak 3, Severe Combined Immunodeficiency, and a New Class of Immunosuppressive Drugs. Immunol Rev. 2005 Feb; 203:127-142.

    John J. O'Shea, Matthew Husa, Denise Li, Sigrun R. Hofmann, Wendy Watford, Joseph L. Roberts, Rebecca H. Buckley, Paul Changelian, and Fabio Candotti. Jak3 and the Pathogenesis of Severe Combined Immunodeficiency. Mol Imm. 41 (2004) 727-737.

    Sarloos MN, Husa MR, Jackson RS 2nd, Ubels JL. Intermediate filament, laminin and integrin expression in lacrimal gland acinar cells: comparison of an immortalized cell line to primary cells, and their response to retinoic acid. Curr Eye Res. 1999 Nov;19(5):439-49.


  • Asaf Presente, MD, PhD 
  • Asaf Presente

    Dr. Presente received his MD-PhD from Northwestern University for his studies of Notch signaling in Drosophila neurobiology. Asaf is a second-year resident who has been accepted into the Pulmonary and Critical Care Fellowship Program.

    Selected Publications

    Presente A., Boyles R., Serway CN., de Belle SJ. and Andres AJ. Notch is required for long-term memory in Drosophila. Proc Natl Acad Sci USA 101(6):1764-8 2004 Feb

    Presente A., Shaw S., Nye JS, Andres JS. Transgene mediated RNA interference defines a novel role for Notch in chemosensory startle behavior. Genesis 34:165-169, 2002 Sep

    Presente A., Andres A., and Nye JS. Requirement for Notch in adulthood for neurological function and longevity. Neuroreport 12(15):3321-3325, 2001 Oct

    Franklin JL., Berechid BE., Cutting FB., Presente A., Chambers CB., Foltz DR., Ferreira A., Nye JS. Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1. Current Biology 9(24):1448-57, 1999 Dec

    Foote SJ., Burt RA., Baldwin TM., Presente A., Roberts AW., Laural YL., Lew AM., Marshall VM. Mouse loci for malaria-induced mortality and the control of parasitaemia. Nature Genetics. 17(4):380-1, 1997 Dec.

    Presente A., Sehgal A., Dudus L., Engelhardt JF. Differentially regulated epithelial expression of an Eph family tyrosine kinase (fHek2) during tracheal surface airway and submucosal gland development. American Journal of Respiratory Cell & Molecular Biology. 16(1):53-61, 1997 Jan.

    Sehgal A., Presente A., Dudus L., Engelhardt JF. Isolation of differentially expressed cDNAs during ferret tracheal development: application of differential display PCR. Experimental Lung Research. 22(4):419-34, 1996 Jul-Aug.

    Sehgal A., Presente A., Engelhardt JF. Developmental expression patterns of CFTR in ferret tracheal surface airway and submucosal gland epithelia. American Journal of Respiratory Cell & Molecular Biology. 15(1):122-31, 1996 Jul.

    Myers JC., Yang H., D'Ippolito JA., Presente A., Miller MK., Dion AS. The triple-helical region of human type XIX collagen consists of multiple collagenous subdomains and exhibits limited sequence homology to alpha 1(XVI). Journal of Biological Chemistry. 269(28):18549-57, 1994 Jul 15.


  • Pradipta Ghosh, MD 
  • Pradipta Ghosh

    Dr. Ghosh obtained her medical degree from Christian Medical College, Vellore, in India. She graduated in 2000 as the Best Outgoing Student in Medicine, Surgery and Overall Best Outgoing Student adjudged by the Indian Medical Association on a nationwide ranking. She started her career in science as a research associate training under Dr. Stuart Kornfeld at Washington University in St. Louis, Missouri, in 2001 before beginning her internship and residency in internal medicine here at UC San Diego in 2003.

    In 2008 she graduated from the Gastroenterology fellowship program and joined as an Assistant Professor on tenure track in the department of Medicine at UCSD. Ongoing work in her laboratory seeks to identify novel signal amplifiers/rheostats in a systematic and unbiased way using a three-pronged approach. Using these approaches her laboratory has already identified new rheostats with surprising functions during cellular processes such as membrane-trafficking, autophagy, survival, apoptosis, mitosis, differentiation and migration. Once systematically applied, these approaches have the real potential to revolutionize our understanding of signal transduction and the diverse biological processes and disease states that they control.

    Ghosh Lab

    Selected Publications

    Do, H., Lee, W.S., Ghosh, P., Hollowell, T., Canfield, W. and Kornfeld, S: Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin. J Biol Chem. 2002 Aug 16; 277(33):29737-44.

    Doray, B., Bruns, K., Ghosh, P. and Kornfeld, S: Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. J Biol Chem. 2002 May 24; 277(21):18477-82.

    Doray, B., Bruns, K., Ghosh, P. and Kornfeld, S: Autoinhibition of the

    -binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8072-7.

    Ghosh, P.*, Doray, B.*, Griffith, J., Geuze, H.J. and Kornfeld, S. :Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. Science. 2002 Sep 6;297(5587):1700-3. (*Equal contribution 1st and 2nd authors)

    Ghosh, P., Dahms, N.M. and Kornfeld, S: Mannose 6-phosphate receptors: new twists in the tale. Nature Rev Mol Cell Biol. 2003 Mar;4(3):202-12.

    Ghosh, P. and Kornfeld, S.: Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem. 2003 Apr 18;278(16):14543-9.

    Ghosh, P. and Kornfeld, S.: AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation. J Cell Biol. 2003 Mar 3;160(5):699-708. Epub 2003 Feb 25.

    Ghosh, P., Griffith, J., Geuze, H.J. and Kornfeld, S. : Mammalian GGAs act together to sort mannose 6-phosphate receptors. J Cell Biol. 2003 Nov 24;163(4):755-66.

    Ghosh, P. and Kornfeld, S.: GGA proteins: Key Players in Protein Sorting at the Trans-Golgi network. Eur. J Cell Biol, 2004, 83: (6)- 257-262.

    Ghosh, P. and Kornfeld , S. : The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-1. Arch Biochem Biophys. 2004 15;426(2):225-30.

    Ghosh P, Strong C, Naugler W, Haghighi P, Carethers JM. Peritoneal mice implicated in intestinal obstruction: report of a case and review of the

    . J Clin Gastroenterol. 2006 May-Jun;40(5):427-30.

    Ghosh, P, Santosa, A.C., Lin GY, Downs TM: De novo calcification of

    and nodal metastases in prostate carcinoma. Prostate Cancer Prostatic Dis. 2006 May 9. (Nature Publishing Group).

    Ghosh, P, Miyai, K and Chojkier, M. Gastric adenocarcinoma inducing portal hypertension: a rare presentation. World J Gastroenterol. 2007 Feb 14;13(6):960-3

    Ghosh, P and Jung, B: Giant Paraesophageal Hernia Causing Compression Pulmonary Atelectasis: Starved for Air when Satiated with Food. J Gastroenterol and Hepat. 2007 Apr;22(4):595.

    Ghosh, P., Olson, RK. and Harmon, G: Sugar Rush in the Colon: Why Incidental Findings on PET scan Justify Colonoscopy?, Amer J. Gastro, 2007 Nov;102(11):2609-10.

    Ghosh, P and Kum, J. Mesenteric panniculitis and sclerosing mesenteritis: a continuum of inflammation fibrosis. Clin Gastroenterol Hepatol. 2007 May;5(5):A32.

    Lee JK., Kum J., Ghosh, P. Gastrointestinal: Glycogenic acanthosis. J Gastroenterol Hepatol. 2007 Sep;22(9):1550.

    Lee JK and Ghosh, P. Non-metastatic cancer of the colon associated with pyogenic

    abscess. Am. J. Gastro, 2008 Mar; 103(3):798-9.

    Lee, JK., Ghosh, P., McWhorter, V., Payne, M., Olson, RK., Ramamoorthy, S., Krinsky, ML., Carethers, JM. Evidence that rectal sarcomatoid carcinoma arises from tubulo-villous adenoma: Tumorigenesis caught in the act. World J Gastroenterology, 2008 Jul 21;14(27):4389-94.

    Ghosh, P., Garcia-Marcos, M, Bornheimer, J. and Farquhar MG. Activation of Gai3 triggers cell migration via interaction with GIV. J. Cell Biol. 2008, Jul 28;182(2):381-93.

    Garcia-Marcos, M*, Ghosh, P* and Farquhar, MG. GIV/Girdin is a non-receptor GEF for Gαi that features a unique molecular target for regulating Akt activity. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3178-83. * Equal contribution.

    Park, F., Lee, J.K., Madduri, G. and Ghosh, P. Generalized Megaviscera of Lupus: Refractory Intestinal Pseudoobstruction, Ureterohydronephrosis and Megacholedochus. July 28, World J Gastroenterology, 2009.

    Lee J.K., Carethers J.M., Ghosh, P, ArterioVenous Malformation within Jejunal Diverticulum: an unusual cause of massive gastrointestinal bleeding. Gastroenterol Res Pract. 2009;2009:384506.

    Ghosh, P., Carethers, J.M., Multiple "apple-core" lesions in chronic ischemic colitis: the great masquerader. Am J Gastroenterol. 2009 Nov;104(11):2870-2.

    Garcia-Marcos, M., Ghosh, P., Ear, J. and Farquhar MG. A structural determinant that renders G{alpha}i sensitive to activation by GIV/Girdin is required to promote cell migration. J Biol Chem. 2010 Feb 15. [Epub ahead of print]. Highlighted in "Faculty of 1000" by Dr Danny Dhanasekharan.

    Ghosh P., Beas, A., Bornheimer SJ., Garcia-Marcos M., Forry E.P., Johannson, C., Jung, B.H., Cabrera, BL., Carethers, J.M. and Farquhar MG. A Gαi-GIV molecular switch decides whether cells migrate or proliferate in response to growth factors. Mol Biol Cell., 2010 July 1;21(13):2338-2354. (Featured as Editor's Choice in Science Signaling AAAS- by Editor in Chief, Nancy Gough, entitled, "Move or Divide?" (;3/129/ec203) and also was selected for "Highlights in MBoC" and nominated for "Paper of the Year" by American Society of Cell Biology" (

    Lee J.K., Bhargava, V., Mittal, R.K., Ghosh, P. Achalasia, Alcohol-stasis and Acute Necrotizing Esophagitis: Connecting the Dots. Digestive Dis. and Sci. 2011 Feb; 56 (2): 612-614.

    Garcia-Marcos, M., Jung, B.H., Ear, J., Cabrera, B.L., Carethers, J.M., and Ghosh, P., Expression of GIV/Girdin, a Metastasis-Related Protein, Predicts Survival in Colorectal Cancer Patients. The FASEB J., 2011 Feb; 25 (2): 590-599. Featured in news article:

    Garcia-Marcos M., Ear, J., Farquhar, M. and Ghosh P. A GEF (GIV) and a GDI (AGS3) Regulate Autophagy by Balancing G protein Activity and Growth Factor Signals. Mol. Biol. Cell, 2011 Mar; 22 (5): 673-686.

    Garcia-Marcos, M., Ghosh, P, and Farquhar, MG. Molecular Mechanism of a Novel Oncogenic Mutation in GNAO. Oncogene, 2011, Feb 14.

    Lord, C., Bhandari, D., Menon, S., Ghassemian, M., Nycz, D., Hay, J., Ghosh, P., and Ferro-Novick, S. Sequential interactions with Sec23 control the direction of Vesicle traffic. In Press, Nature (Article), 2011. DOI: 10.1038/nature09969.

    Ghosh, P., Garcia-Marcos, M., and Farquhar, M.G. GIV/Girdin is a Rheostat which Fine-tunes Growth Factor Signals During Tumor progression. In Press, Cell Adhesion and Migration, Vol 5, Issue 3. 2011.

  • Stina Mui, MD, PhD 
  • Stina Mui

    Dr. Mui graduated magna cum laude with her BA from Harvard University in 1995 and entered the MD-PhD Program at UC San Diego in 1996. She earned her PhD in Neurosciences in 2002 and her MD in 2004 from UC San Diego.

    In 2001, Dr. Mui was awarded the Washington Square Health Foundation Scholar, The Salk Institute.

    Dr. Mui then became a hematology-oncology fellow and did research in systems biology of cancer in the laboratory of Dr. Trey Ideker, Division of Medical Genetics and Department of Bioengineering. 

    Selected Publications

    Mui SH, Kim JW, Lemke G, Bertuzzi S. (2005) Vax genes ventralize the embryonic eye. Genes Dev. 2005 May 15;19(10):1249-59

    Mui SH, Hindges R, O'Leary DD, Lemke G, Bertuzzi S. (2002) The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development 129(3):797-804

    Rebeck GW, Moir RD, Mui S, Strickland DK, Tanzi RE, Hyman BT. (2001) Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain Res Mol Brain Res 87(2): 238-245.

    Bertuzzi S, Hindges R, Mui SH, O'Leary DDM, Lemke G. (1999) The homeodomain protein Vax1 is required for axon guidance in the developing eye and brain. Genes and Development 13:3092-3105.

    Mui SH, Bertuzzi S, Adlkofer K, Lemke G. (1999) Ventral Anterior Homeobox 2 (VAX2) is implicated in axon guidance in the central and peripheral nervous systems. Society for Neuroscience abstract. Presented as poster in Society for Neuroscience annual meeting in Miami, Florida. October 1999.

    Mui S, Briggs M, Chung H, Wallace RB, Gomez-Isla T, Rebeck GW, Hyman BT. (1996) A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele. Neurology 47(1):196-201.

    Mui S, Rebeck GW, McKenna-Yasek D, Hyman BT, Brown RH Jr. (1995) Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis. Ann Neurol 38(3):460-3.

    Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT. (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 41(1):17-24.

    Hyman BT, Gomez-Isla T, Rebeck GW, Briggs M, Chung H, West HL, Greenberg S, Mui S, Nichols S, Wallace R, Growdon JH. (1996) Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease. Ann N Y Acad Sci 802:1-5

    Gomez-Isla T, Rebeck GW, Growdon JH, Mui S, Brown RH, Hyman BT. (1995) Molecular epidemiology of Alzheimer's disease: effect of apoE genotype. Neurology 45: A471.

    Hyman BT, West HL, Harr S, Gomez-Isla T, Mui S. (1994) Quantitative neuropathology in Alzheimer disease: neuronal loss in high order association cortex parallels dementia. Neurobiol Aging 44: S141.

    Bullimore MA, Mui S, Wood JM, Swenson KH. (1992) Displacement thresholds for uncorrelated random dot stimuli. Paper presented to the Association for Research in Vision and Ophthalmology, May 1992, Sarasota, Florida. Invest Ophthalmol Vis Sci 1992.

    Tamkins S, Bullimore MA, Mui S, Wood JM, Swenson KH. (1991) The encoding of small displacements in normal and abnormal vision. Optom Vision Sci suppl 68: 80.


  • Lai-Jung Tai, MD, PhD 
  • Lai-Jung Tai

    Dr. Tai came to the PSTP at UC San Diego after graduating summa cum laude from UC San Diego and then obtained MD and PhD degrees from Northwestern University in 2003. Lai did a fellowship in endocrinology and worked in transcriptional regulation in the laboratory of Dr. Ron Evans at the Salk Institute.

    Selected Publications

    MacKenna, DA, Omens, JH, Tai, LJ, McCulloch, AD, Covell, JW: Effects of Collagenase in the Mechanics of the Arrested Rat Left Ventricle(LV). FASEB, 6(4): A1487, 1992.

    Evans, SM, Tai, LJ, Tan, VP, Newton, CB, Chien, KR: Cardiac: Fibroblast Heterokaryons Reveal lack of Dominance of the Cardiac Muscle Phenotype. Molecular and Cellular Biology, 14(6): 4269-79, 1994.

    Tai, LJ, McFall, SM, Huang, K, Demeler, B, Fox, SG, Brubaker, K, Radhakrishnan I, Morimoto RI: Structure-Function Analysis of the Heat Shock Factor Binding Protein Reveals a Protein Composed Solely of a Highly Conserved and Dynamic Coiled-Coil Trimerization Domain. Journal of Biological Chemistry, 277: 735-745, 2002.

    Westerheide, S, Tai, LJ, Schwabenbauer, S, Morimoto, RI: Heat Shock Factor 1 (HSF1) Mediated Nonsteroidal Anti-inflammatory Drug Activation of the Heat Shock Response Leading to Cytoprotection. In preparation.


  • Paul Chi-Jen Cheng, MD, PhD 
  • Paul Chi-Jen Cheng

    Dr. Cheng completed his PhD and MD in 2002 at Northwestern University. In July of 2002, Dr. Cheng began his research residency training here at UC San Diego and began fellowship in the Division of Hematology-Oncology in 2004. He served as chief fellow in the division in 2007. He then became a postdoctoral research associate at the Salk Institute and worked with Dr. Tony Hunter in the Molecular and Cellular Biology Laboratory. 

    Selected Publications

    Cheng, P.C. and Wong, G. (1996) Honey bee propolis: prospects in medicine. Bee World 77(1): 8-15.

    Peng, C.Y.S., Mussen, E., Fong, A., Cheng, P., Wong, G. and Montague, M.A. (1996) Laboratory and field studies on the effects of the antibiotic tylosin on honey bee Apis mellifera L. (Hymenoptera: Apidae) development and prevention of American Foulbrood Disease. J. Invert. Pathol. 67: 65-71.

    Song, W., Cho, H., Cheng, P. and Pierce, S.K. (1995) Entry of B cell antigen receptor and antigen into class II peptide-loading compartment is independent of receptor cross-linking. J. Immunol. 155(9): 4255-4263.

    Brown, B.K., Li, C., Cheng, P.C., and Song, W. (1999) Trafficking of the Ig/Ig� heterodimer with membrane Ig and bound antigen to the major histocompatibility complex class II peptide-loading compartment. J. Biol. Chem. 274: 11439-11446.

    Cheng, P.C., Steele, C.R., Gu, L., Song, W., and Pierce, S.K. (1999) MHC class II antigen processing in B cells: Accelerated intracellular targeting of antigens. J. Immunol. 162: 7171-7180.

    Wagle, N.M., Cheng, P., Kim, J., Sproul, T.W., Kausch, K.D., and Pierce, S.K. (1999) B-lymphocyte signaling receptors and the control of class-II antigen processing. Curr. Top. Microbiol. Immunol. 254: 106-126.

    Cheng, P.C., Dykstra, M.L., Mitchell, R.N., and Pierce, S.K. (1999) A role for lipid rafts in BCR signaling and antigen targeting. J. Exp. Med. 190: 1549-1560.

    Sproul T.W., Cheng P.C., Dykstra M.L., Pierce S.K. (2000) A role for MHC class II antigen processing in B cell development. Int. Rev. Immunol. 19(2-3):139-155.

    Cherukuri A., Cheng P.C., Sohn H.W., Pierce S.K. (2001) The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts. Immunity. 14(2): 169-179.

    Cheng P.C., Brown B.K., Song W., and Pierce S.K. (2001) Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J. Immunol. 166: 3693-3701.

    Cheng, P.C., Cherukuri, A., Dykstra, M., Malapati, S., Sproul, T., Chen, M.R., and Pierce, S.K. (2001) Floating the raft hypothesis: The roles of lipid rafts in B cell antigen receptor function. Semin. Immunol. 13:107-114.

    Cherukuri, A., Cheng, P.C., and Pierce, S.K. (2001) The Role of the CD19/CD21 Complex in B Cell Processing and Presentation of Complement-Tagged Antigens. J. Immunol. 167: 163-172.

  • Chester Drum, MD, PhD 
  • Chester Drum

    Dr. Drum received his MD from the University of Chicago in 2003. He received his PhD from the University of Chicago in 2002 for his studies of anthrax adenylyl cyclase exotoxin. He did his fellowship training in cardiology at Harvard. Dr. Drum has received the Harold Lamport Award for Best Dissertation in the Biological Sciences, University of Chicago, Division of the Biological Sciences and the Award for Difficult Structure Determination, Diffraction Methods Gordon Conference.

    Selected Publications

    Drum, C. L., Yan, S. Z., Bard, J., Shen, Y. Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., and Tang, W. J. (2002). "Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin." Nature, 415(6870), 396-402.

    Drum, C. L., Shen, Y., Rice, P. A., Bohm, A., and Tang, W. J. (2001). "Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin." Acta Crystallogr D Biol Crystallogr, 57(Pt 12), 1881-4.

    Drum, C. L., Yan, S. Z., Sarac, R., Mabuchi, Y., Beckingham, K., Bohm, A., Grabarek, Z., and Tang, W. J. (2000). "An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis." J Biol Chem, 275(46), 36334-40.

    Tang, W. J., Yan, S., and Drum, C. L. (1998). "Class III adenylyl cyclases: regulation and underlying mechanisms." Adv Second Messenger Phosphoprotein Res, 32, 137-51

    Benzinger, G. R., Drum, C. L., Chen, L. Q., Kallen, R. G. and Hanck, D. A. (1997). "Differences in the binding sites of two site-3 sodium channel toxins." Pflugers Arch, 434(6), 742-9.

    Dias-Kadambi, B. L., Combs, K. A., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1996). "The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B." J Biol Chem, 271(39), 23828-35.

    Dias-Kadambi, B. L., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1996). "Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel." J Biol Chem, 271(16), 9422-8.

    Drum, C. L., Benzinger, G. R, Chen, L-Q., Kallen, R. G., Hanck, D. A. (1996). "Domain localization of isoform-specific determinants of site 3 toxin modification of voltage-gate Na channels." Biophys J, 70(2), A318

    Kelso, G. J., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1996). "Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel." Biochemistry, 35(45), 14157-64.

    Khera, P. K., Benzinger, G. R., Lipkind, G., Drum, C. L., Hanck, D. A., and Blumenthal, K. M. (1995). "Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination." Biochemistry, 34(27), 8533-41.

Additional Past Residents

  • Antine E. Stenbit, MD, PhD 
  • Sandip K. Datta, MD 
  • Sandip K. Datta

    Dr. Datta received his MD with thesis from UC San Francisco. The thesis portion of his work focused in signaling through the B cell receptor with Dr. A. DeFranco. He joined the program in 1996, completing it in 2001 with ABIM certification in internal medicine and infectious disease. He worked with Professor Eyal Raz on signaling via Toll-like receptors. He then became an Assistant Professor of Medicine at UC San Diego and he is the recipient of a Mentored Clinician Scientist Award from the National Institutes of Health.

    Selected Publications

    Datta SK, Cho HJ, Takabayashi K, Horner AA, Raz E. Antigen-immunostimulatory oligonucleotide conjugates (AIC): mechanisms and applications. Immunological Reviews 2004, 199: 217-226.

    Redecke V, Hecker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. Activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. Journal of Immunology 2004, 172: 2739-2743.

    Datta SK, Takabayashi K, Raz E. The therapeutic potential of antigen-oligonucleotide conjugates. In: Therapeutic Oligonucleotides: Antisense, RNAi, DNA Decoys, and DNA Chips, Y.S. Cho-Chung, ed., Annals of the New York Academy of Sciences 2003, 1002: 105-112.

    Datta SK, Redecke V, Prilliman K, Takabayashi K, Corr M, Tallant T, Didonato J, Dziarski R, Akira S, Schoenberger SP, Raz E. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. Journal of Immunology 2003, 170: 4102-4110.

    Datta SK, Horner AA, Takabayashi K, Raz E. Immunostimulatory DNA-based immunization: hope for an HIV vaccine? In: Microbial DNA and Immune Modulation, E. Raz, ed., Humana Press, 2002, pp. 239-254.

    Cho HJ, Datta SK, Raz E. Cross-priming of CD8+ T cells by immunostimulatory sequence DNA. In: Microbial DNA and Immune Modulation, E. Raz, ed., Humana Press, 2002, pp. 137-149.

    Cho HJ, Hayashi T, Datta SK, Takabayashi K, Van Uden JH, Horner AA, Corr MP, Raz E. Type I interferons (IFN???) promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. Journal of Immunology 2002, 168: 4907-4913.

    Horner AA, Datta SK, Takabayashi K, Belyakov IM, Hayashi T, Cinman N, Nguyen M-D, Van Uden JH, Berzofsky JA, Richman DD, Raz E. Immunostimulatory DNA-based vaccines elicit multi-faceted immune responses against HIV at systemic and mucosal sites. Journal of Immunology 2001, 167: 1584-1591.

    Datta SK, Kirkland TN. Microbiology and Antimicrobial Therapy of Vertebral Osteomyelitis. Seminars in Spine Surgery 2000, 12: 176-182.

    DeFranco AL, Richards JD, Blum JH, Stevens TL, Law DA, Chan VWF, Datta SK, Foy SP, Hourihane SL, Gold MR. Signal transduction by the B-cell antigen receptor. Annals of the New York Academy of Sciences 1995, 766: 195-201.

    DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VWF, Foy SP, Datta SK, Matsuuchi L. Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis. Advances in Experimental Medicine and Biology 1994, 365: 9-22.

    DeFranco AL, Blum JH, Stevens TL, Law DA, Chan VWF, Foy SP, Datta SK, Matsuuchi L. Structure and Function of the B-Cell Antigen Receptor. Chemical Immunology 1994, 59: 156-172.

    Law DA, Chan VWF, Datta SK, DeFranco AL. B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Current Biology 1993, 3: 645-657.

  • Barbara Jung, MD