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Dr. Dan Kaufman

Dr. Dan Kaufman






Dan S. Kaufman, MD, PhD
Professor of Medicine, Division of Regenerative Medicine.
Director of Cell Therapy, UCSD

The Kaufman laboratory uses human pluripotent stem cells to understand the development of blood cells. The aim is to use human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs) as a resource to produce blood and immune cells (mainly natural killer cells) for new clinical applications for treatment of relapsed/refractory cancers -- both hematologic malignancies and solid tumors. We are also working on production of blood cells (monocytes and macrophages) that can be used for tissue repair and regeneration.

Dr. Kaufman also provides clinical care for patients with hematological malignancies, with special interest in blood and marrow transplantation (BMT) and immune therapies.

About the Lab

Cell-based immunotherapies have gained considerable interest over the past few years. Our lab utilizes hESCs and iPSCs to produce human immune cells, primarily focused on natural killer (NK) cell development. We have demonstrated the ability to routinely produce engineered iPSC-derived NK cells with improved anti-tumor activity by expression of chimeric antigen receptors (CARs), stabilized CD16 expression and other enhancements. These engineered iPSC-derived NK cells are now in clinical trials for treatment of patients with relapsed or refractory cancers. We also have projects to produce iPSC-derived macrophages that can be used both for anti-cancer therapies, as well as tissue repair and regeneration. Another area of interest is to use a CRISPR/Cas-based screening strategy to identify novel regulators of NK cell activity. Together, these projects will allow us to produce standardized, off-the-shelf, targeted immunotherapy to better treat and cure both hematologic malignancies and solid tumors that are refractory to current treatments.

More about our lab's research >

Contact Us

Lab Location
University of California - San Diego
Sanford Consortium for Regenerative Medicine
2880 Torrey Pines Scenic Dr.
La Jolla, CA 92037

Mailing Address
University of California - San Diego
9500 Gilman Drive #0695
La Jolla, CA 92093-0695

Phone Numbers
​Office ​858-822-1777
Assistant​ ​858-246-1294
​Lab
​858-246-1494
Lab ​FAX

Clinic

Clinic FAX
​858-246-1579

858-822-6600

858-822-6205