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Dr. Dan Kaufman

Dr. Dan Kaufman

Dan S. Kaufman, MD, PhD
Professor of Medicine, Division of Regenerative Medicine.
Director of Cell Therapy, UCSD

The Kaufman laboratory uses human pluripotent stem cells to understand the development of blood cells (both hematopoietic stem cells and functional lymphocytes: T cells and NK cells) and related mesodermal cell populations (including bone, endothelial and smooth muscle/vascular cells). The aim is to use human pluripotent stem cells as a resource to produce blood and immune cells for new clinical applications for treatment of relapsed/refractory cancers -- both hematologic malignancies and solid tumors.

Dr. Kaufman also provides clinical care for patients with hematological malignancies, with special interest in blood and marrow transplantation (BMT) and immune therapies.

About the Lab

Individuals produce billions of blood cells every day. The stimuli and genes that allow individual hematopoietic stem cells (HSCs) to produce mature progeny such as red blood cells, white blood cells, lymphocytes and platelets has been studied in considerable depth and serves as a model system in developmental biology. However, how the multipotent HSCs is derived during embryogenesis remains poorly understood, especially in the human system.

Our lab studies focus on this beginning stage of blood development: the transition from embryonic stem cell to hematopoietic stem cell. More recently, we have emphasized studies on use of human pluripotent stem cells to produce functional human lymphocytes to provide a standardized, off-the-shelf, targeted immunotherapy to better treat and cure both hematologic malignancies and solid tumors that are refractory to current treatments.

More about our lab's research >

Contact Us

Lab Location
University of California - San Diego
Sanford Consortium for Regenerative Medicine
2880 Torrey Pines Scenic Dr.
La Jolla, CA 92037

Mailing Address
University of California - San Diego
9500 Gilman Drive #0695
La Jolla, CA 92093-0695

Phone Numbers
​Office ​858-822-1777
Assistant​ ​858-246-1294
Lab ​FAX


Clinic FAX