Angioedema studies use human tissue and are focused on bradykinin-mediated swelling. Current projects include: investigating genetic determinants of angioedema severity, the role of bradykinin receptors in swelling, and the cell biology of C1 inhibitor deficiency.
In collaboration with the US HAEA Angioedema Center, of which Dr. Zuraw is Director, the laboratory is studying improved assays for the diagnosis of angioedema. Dr. Zuraw is also an active participant with Dr. Marc Riedl in a number of clinical trials.
Asthma studies focus on the role of the airway epithelial cell in inflammatory airway disease. The laboratory is studying the impact of glucocorticoid-induced leucine zipper (GILZ) in down-regulating airway inflammation as well as strategies to increase the expression of GILZ to treat asthmatic inflammation. Another project is investigating the roles of B2 and B1 bradykinin receptors in allergic airway inflammation. A third project is looking at the role of transient receptor potential channels in airway inflammation, including allergic and non-allergic rhinitis.