Active research programs in the lab include:
- The role of the multiligand receptor RAGE and of the calgranulin family of RAGE ligands in chondrogenic differentiation and cartilage pathology
- The molecular pathology of soft tissue and artery calcification in inorganic pyrophosphate-deficient mice
- The role of TLR-mediated innate immunity in cartilage and synovial joint biology
Current work in the Terkeltaub laboratory also includes studies focused on the tug of war between resting chondrocyte differentiation and maturation to chondrocyte hypertrophy. Chondrocyte hypertrophy mediates osteoarthritis and endochondral calcification mechanisms, we are investigating the molecular pathologic role of transglutaminases TG2 and FXIIIA, and of chemokine receptor signaling, in cartilage biology and in osteoarthritis in specific.