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Dr. Eyal Raz

Dr. Eyal Raz Dr. Eyal Raz, Professor of Medicine in the University of California San Diego, received his MD degree in 1981 from the Hebrew University at the Hadassah Medical School, Jerusalem, Israel.
The research in his laboratory explores questions in basic science and attempts to apply its results to translational research/medicine. Over the last decade, the Raz laboratory has explored diverse biological aspects induced by various microbial PAMPs on the activation of innate immunity, adaptive immunity and their impact on vaccination and the regulation of inflammatory responses such as allergic diseases. These findings led to the founding of a few biotech companies, one of them Dynavax, of which he was a Director and the Chief Scientific Officer during 1997-2000, is in the final stage of clinical trials. Current projects in his laboratory are addressing the role of TRP channels on T cell and epithelial cell activation.

About the Lab

The current research in Dr. Raz's laboratory focuses on the fundamentals of host interactions with environmental factors. His team studies host response to microbial Toll-like receptor (TLR) and the non-TLR stimulation. In addition they explore the role of members of the Transient receptor potential (TRP) family by which the host interacts with diverse chemical and biochemical originate from the environment.
His laboratory explores the consequences of these host-environmental interactions on the induction of inflammatory processes and immune responses in the affected host. These include vaccines design against various infectious agents, modulation of allergic diseases, inflammatory bowel diseases and cancer.

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Research Highlights or News

  • The Diverse Contribution of TLR Pathways to Intestinal Homeostasis.
  • Th17 subsets: Differential roles in immune defense mechanisms at the G-I mucosa.
  • Intestinal Immune System Host-Environment Interactions.
  • Cyclic AMP-induced Th17 subset: Its role in intestinal homeostasis and inflammation.