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Dr. Monica Guma Lab

Monica Guma, MD., PhD.Monica Guma, MD., PhD.,  received her M.D. at Autonomous University of Barcelona, Spain. She then completed a rheumatology fellowship at the Germans Trias i Pujol Hospital and her Ph.D. in immunology at Pompeu Fabra University, both in Barcelona, Spain. She later moved to University of California at San Diego for her postdoctoral fellowship and rheumatology clinical fellowship. Dr. Guma is now  an Assistant Professor of Medicine at UC San Diego.

About the Lab

The Guma lab studies metabolic changes in cells critical for rheumatoid arthritis and psoriatic arthritis pathogenesis, specially fibroblast-like synovioctyes and macrophages to offer a novel and additional approach for combination therapy independent of systemic immunosuppression. We also conduct clinical and translational investigations to identify noninvasive circulating metabolic biomarkers to identify patients at high risk for joint damage.
We also are interested in gaining a better understanding of relapsing polychondritis, a rare condition characterized by recurrent inflammation of cartilage, not only in joints but also in other tissues throughout the body.

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Research Highlights

  • Discovering new disease mechanisms: recent findings published in the Arthritis & Rheumatism: Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes.
  • Linking patient care and basic science research: Sweeney SR, Kavanaugh A, Lodi A, Wang B, Boyle D, Tiziani S, Guma M. Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis.