Dr. Gary S. Firestein’s work focuses on the pathogenesis and treatment of rheumatoid arthritis. He was among the first to map the synovial cytokine profile of RA and demonstrate the dominance of macrophage and fibroblast products. These studies played a pivotal role in the development of the highly effective anti-TNF and other anti-cytokine approaches to RA. More recently, his group focused on targeting kinases in inflammatory diseases and mapping the epigenome in RA.
The lab has trained nearly 40 post-doctoral fellows, 10 of whom have become division or department heads.