Dr. David Broide

Dr Broide is a Professor of Medicine at the University of California San Diego. He is the author of over 160 publications related to mechanisms of asthma results of which have been published in Proc National Acad Sciences, New Eng J Med, J Clin Invest, J Immunol, and Nature Reviews Drug Discovery.  His basic and translational research program focusing on asthma has been funded by the National Institutes of Health for over 25 years. Dr Broide is currently the recipient of an NIH MERIT award, and is principal investigator on several NIH RO1 grants, an NIH Asthma and Allergic Disease Center program project grant, and an NIH T32 training grant in molecular mechanisms of allergic inflammation. Training in Molecular and Cell Biology of Allergy

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About The Lab

Dr Broide’s research focuses on understanding the role of airway inflammation in contributing to asthma and airway remodeling. Studies have focused on eosinophils as well as innate immune mechanisms (TLR-9, TGF-b, Siglec-F, ORMDL3) in regulating inflammation and remodeling.

Research Highlights

1.    Recent Publication
Dr. Broide’s lab demonstrated the importance of ORMDL3 to asthma
Miller M, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, Rosenthal P, Mueller JL, Hoffman HM, Suzukawa M, Niwa M, Broide DH. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A.  109:16648-53 (2012).

2.    NIH Research Grant Support
Dr. Broide is PI on the following NIH grants:
NIH MERIT AWARD: Eosinophil tissue trafficking (2011-2016)
NIH RO1: Chromosome 17q, allergic inflammation, and remodeling (2013-2018)
NIH Asthma and Allergic Disease Center: Airway inflammation and airway remodeling (2011-2016)

3.    NIH T32 Training Grant
Dr. Broide is PI of an NIH T32 training grant
NIH T32: Training in Molecular and Cell Biology of Allergy (2009-2014)

4.    Mentorship
Dr. Broide is sponsor of an NIH KO8 award to Taylor Doherty MD an Assistant Professor of Medicine at the University of California San Diego