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Publications from the Broderick Lab
A list of selected recent publications is below. See full list of publications from PubMed

McGeough MD, Wree A, Inzaugarat M, Haimovich A, Johnson CD, Pena CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017. doi:10.1172/JCI90699.

Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay SJ, Chattaraj P, Khanna SA, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. NLRP3 mutation and cochlear autoinflammation cause syndromic and non syndromic hearing loss DFNA34 responsive to anakinra therapy. Proc. Natl. Acad. Sci. U.S.A.  2017. 114(37):E7766-E7775.

Kuemmerle-Deschner JB, Verma D, Endres T, Broderick L, de Jesus AA, Hofer F, Blank N, Krause K, Rietschel C, Horneff G, Aksentijevich I, Lohse P, Goldbach-Mansky R, Hoffman HM, Benseler SM.  Clinical and molecular phenotypes of low-penetrance variants in NLRP3: Diagnostic and therapeutic challenges. Arthritis Rheumatol. 2017 Jul 10. doi: 10.1002/art.40208. 

Radhakrishna S.M., Grimm A.E., Broderick L. Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. BMC Pediatrics. 2017. 17(1):108.

Broderick L. Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan;16(1):2. doi: 10.1007/s11882-015-0578-1. PMID: 26707379

Hoffman HM, Broderick L. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 Jul;138(1):3-14. doi: 10.1016/j.jaci.2016.05.001. PMID: 27373321

Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. The Inflammasome and Autoinflammatory Syndromes. Annu Rev Pathol. 2015; 10: 395. PMID: 25423351.

Broderick, L., Gandhi, C., Mueller, J.L., Putnam, C.D., Shayan, K., Peterson, K.S., Aceves, S.S., Sheets, R.M., Peterson, B.M., Newbury, R.O., Giclas, P.C., Hoffman, H.M., and J.F. Bastian. Complement Factor I Deficiency Presenting as Acute Hemorrhagic Leukoencephalitis. J Clin Immunol. 2013; 311: 162-171.

Brydges, S.D.,* Broderick, L.,* McGeough, M.D., Pena, C.A., Mueller, J.L., Hoffman, H.M. Divergence of IL-1, IL-18 and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013. 123(11): 4695–4705.    (* denotes shared first authorship)

McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD, (2012) Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models. J Immunol 189(6):2707-11. PMCID: PMC3495128

Broderick, L., Tremoulet AH, Burns JC, Bastian JF and HM Hoffman. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011. 127: e489-93.