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Publications

Publications from the Broderick Lab
A list of selected recent publications is below. See full list of publications from PubMed

Primary Articles
Luu I, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Pransky S, Broderick L. Undifferentiated recurrent fevers in pediatrics respond to tonsillectomy. Clinical Immunology. 2021. PMID: 33636366

Broderick L, Hoffman HM. Pediatric recurrent Fever and Autoinflammation from the Perspective of an Allergist/Immunologist. J Allergy Clin Immunol. 2020. 146(5):960-966.e2. PMID: 33002514

Luu I, Sharma A, Guaderrama M, Peru M, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Newbury R, Pransky S, Gilbert JA, Broderick L. Immune dysregulation in the tonsillar microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. J Clin Immunol. 2020. 40(1):179-190. doi: 10.1007/s10875-019-00724-2. PMID: 31807979

Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kurchova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD and HM Hoffman. Mutations in topoisomerase 2beta result in a syndromic B cell immunodeficiency. Nat Commun. 2019 Aug 13;10(1):3644. doi: 10.1038/s41467-019-11570-6. PMID: 31409799

McGeough MD, Wree A, Inzaugarat M, Haimovich A, Johnson CD, Pena CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017. doi:10.1172/JCI90699.

Broderick, L., Gandhi, C., Mueller, J.L., Putnam, C.D., Shayan, K., Peterson, K.S., Aceves, S.S., Sheets, R.M., Peterson, B.M., Newbury, R.O., Giclas, P.C., Hoffman, H.M., and J.F. Bastian. Complement Factor I Deficiency Presenting as Acute Hemorrhagic Leukoencephalitis. J Clin Immunol. 2013; 311: 162-171.

Brydges, S.D.,* Broderick, L.,* McGeough, M.D., Pena, C.A., Mueller, J.L., Hoffman, H.M. Divergence of IL-1, IL-18 and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013. 123(11): 4695–4705.    (* denotes shared first authorship)

Recent Reviews
Broderick L. Hereditary Autoinflammatory Disorders: Recognition and Treatment. Immunol Allergy Clin North Am. 2019 Feb;39(1):13-29. doi: 10.1016/j.iac.2018.08.004. PMID: 30466770

Broderick L. Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan;16(1):2. doi: 10.1007/s11882-015-0578-1. PMID: 26707379

Hoffman HM, Broderick L. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 Jul;138(1):3-14. doi: 10.1016/j.jaci.2016.05.001. PMID: 27373321

Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. The Inflammasome and Autoinflammatory Syndromes. Annu Rev Pathol. 2015; 10: 395. PMID: 25423351.

Collaborative Studies
Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. Alternative splicing regulates stochastic NLRP3 activity. Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1. PMID: 31324763.

Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay SJ, Chattaraj P, Khanna SA, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ. NLRP3 mutation and cochlear autoinflammation cause syndromic and non syndromic hearing loss DFNA34 responsive to anakinra therapy. Proc. Natl. Acad. Sci. U.S.A.  2017. 114(37):E7766-E7775.

Kuemmerle-Deschner JB, Verma D, Endres T, Broderick L, de Jesus AA, Hofer F, Blank N, Krause K, Rietschel C, Horneff G, Aksentijevich I, Lohse P, Goldbach-Mansky R, Hoffman HM, Benseler SM.  Clinical and molecular phenotypes of low-penetrance variants in NLRP3: Diagnostic and therapeutic challenges Arthritis Rheumatol. 2017 Jul 10. doi: 10.1002/art.40208.

Qu, C., Bonar, S.L., Hickman C.L., Abu-Amer, S., McGeough, M.D., Pena, C., Broderick, L., Yang, C., Grimston, S.K., Kading, K., Abu-Amer, Y., Novack, D.V., Hoffman, H.M., Civitelli, R., Mbalaviele, G. NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. 2014. FASEB J. 2015 Apr;29(4):1269-79.

Yu, J., Murakami, T., Nagasu, H., Hoang, H., Broderick, L., Hoffman, H.M., Horng, T. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc. Natl. Acad. Sci. U.S.A.  2014. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15514-9.