Primary Articles from the Aceves Laboratory

Manresa MC, Chiang AWT, Kurten RC, Dohil R, Brickner H, Dohil L, Herro R, Akuthota P, Lewis NE, Croft M, Aceves SS. Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype. Gastroenterology. 2020 Jul 23:S0016-5085(20)34997-0. doi: 10.1053/j.gastro.2020.07.035. Online ahead of print. PMID: 32712105

Nhu QM, Hsieh L, Dohil L, Dohil R, Newbury RO, Kurten R, Moawad FJ, Aceves SS. Antifibrotic Effects of the Thiazolidinediones in Eosinophilic Esophagitis Pathologic Remodeling: A Preclinical Evaluation.Clin Transl Gastroenterol. 2020 Apr;11(4):e00164. doi: 10.14309/ctg.0000000000000164.PMID: 32352681 
Summary- This article demonstrates the potential role of thiazolidinediones in treating complications of eosinophilic esophagitis

Duong LD, Rawson R, Bezryadina A, Manresa MC, Newbury RO, Dohil R, Liu Z, Barrett K, Kurten R, Aceves SS. TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis. Mucosal Immunol. 2019 Oct 21;. doi: 10.1038/s41385-019-0214-9. [Epub ahead of print] PubMed PMID: 31636346; NIHMSID:NIHMS1540835.

Kurten RC, Rawson R, Shoda T, Duong LD, Adejumobi D, Levy R, Newbury RO, Rothenberg ME, Akuthota P, Wright BL, Dohil R, Jones SM, Aceves SS. Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. Sci Rep. 2019 Apr 17;9(1):6206. doi: 10.1038/s41598-019-41147-8. PubMed PMID: 30996235; PubMed Central PMCID: PMC6470157.

Hassan M, Aceves S, Dohil R, Gharibans A, Newbury R, Proudfoot J, Mousa H. Esophageal Compliance Quantifies Epithelial Remodeling in Pediatric Patients With Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):559-565. doi: 10.1097/MPG.0000000000002202. PubMed PMID: 30418408; PubMed Central PMCID: PMC6453699.

Doshi A, Khamishon R, Rawson R, Duong L, Dohil L, Myers SJ, Bell B, Dohil R, Newbury RO, Barrett KE, Kurten RC, Aceves SS. Interleukin 9 Alters Epithelial Barrier and E-cadherin in Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):225-231. doi: 10.1097/MPG.0000000000002144. PubMed PMID: 30211842; PubMed Central PMCID: PMC6344288.

Rawson R, Yang T, Newbury RO, Aquino M, Doshi A, Bell B, Broide DH, Dohil R, Kurten R, Aceves SS. TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2016 Sep;138(3):791-800.e4. doi: 10.1016/j.jaci.2016.02.028. Epub 2016 Apr 8. PubMed PMID: 27212082; PubMed Central PMCID: PMC5014565.

Tkachenko E, Rawson R, La E, Doherty TA, Baum R, Cavagnero K, Miyanohara A, Dohil R, Kurten RC, Aceves SS. Rigid substrate induces esophageal smooth muscle hypertrophy and eosinophilic esophagitis fibrotic gene expression. J Allergy Clin Immunol. 2016 Apr;137(4):1270-1272.e1. doi: 10.1016/j.jaci.2015.09.020. Epub 2015 Nov 2. PubMed PMID: 26542032; PubMed Central PMCID: PMC4826849.

Rajan J, Newbury RO, Anilkumar A, Dohil R, Broide DH, Aceves SS. Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids. J Allergy Clin Immunol. 2016 Jan;137(1):147-156.e8. doi: 10.1016/j.jaci.2015.05.045. Epub 2015 Jul 30. PubMed PMID: 26233926; PubMed Central PMCID: PMC4715736.

Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide DH, Aceves SS. The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis. PLoS One. 2015;10(12):e0144651. doi: 10.1371/journal.pone.0144651. eCollection 2015. PubMed PMID: 26656423; PubMed Central PMCID: PMC4678166.

Doherty TA, Baum R, Newbury RO, Yang T, Dohil R, Aquino M, Doshi A, Walford HH, Kurten RC, Broide DH, Aceves S. Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Sep;136(3):792-794.e3. doi: 10.1016/j.jaci.2015.05.048. Epub 2015 Jul 30. PubMed PMID: 26233928; PubMed Central PMCID: PMC4562810.

Beppu L, Yang T, Luk M, Newbury RO, Palmquist J, Dohil R, Kurten RC, Broide DH, Aceves SS. MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy. J Pediatr Gastroenterol Nutr. 2015 Aug;61(2):194-9. doi: 10.1097/MPG.0000000000000668. PubMed PMID: 25539192; PubMed Central PMCID: PMC4478274.

Beppu LY, Anilkumar AA, Newbury RO, Dohil R, Broide DH, Aceves SS. TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Nov;134(5):1100-1107.e4. doi: 10.1016/j.jaci.2014.04.004. Epub 2014 May 13. PubMed PMID: 24835503; PubMed Central PMCID: PMC4231011.

Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS. Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Jun;131(6):1576-82. doi: 10.1016/j.jaci.2013.02.042. Epub 2013 Apr 25. PubMed PMID: 23623266; PubMed Central PMCID: PMC3699422.

Dohil R, Newbury RO, Aceves S. Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis. Dig Dis Sci. 2012 May;57(5):1413-9. doi: 10.1007/s10620-011-1991-5. Epub 2011 Dec 2. PubMed PMID: 22134787.

Dohil R, Aceves SS, Dohil MA. Oral viscous budesonide therapy in children with epidermolysis bullosa and proximal esophageal strictures. J Pediatr Gastroenterol Nutr. 2011 Jun;52(6):776-7. doi: 10.1097/MPG.0b013e31820a9310. PubMed PMID: 21593650.

Aceves SS, Chen D, Newbury RO, Dohil R, Bastian JF, Broide DH. Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction. J Allergy Clin Immunol. 2010 Dec;126(6):1198-204.e4. doi: 10.1016/j.jaci.2010.08.050. Epub 2010 Nov 3. PubMed PMID: 21047675.

Dohil R, Newbury R, Fox L, Bastian J, Aceves S. Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial. Gastroenterology. 2010 Aug;139(2):418-29. doi: 10.1053/j.gastro.2010.05.001. Epub 2010 May 7. PubMed PMID: 20457157.

Aceves SS, Newbury RO, Chen D, Mueller J, Dohil R, Hoffman H, Bastian JF, Broide DH. Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy. 2010 Jan;65(1):109-16. doi: 10.1111/j.1398-9995.2009.02142.x. Epub 2009 Oct 1. PubMed PMID: 19796194; PubMed Central PMCID: PMC2807896.

Aceves SS, Newbury RO, Dohil MA, Bastian JF, Dohil R. A symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammation. Ann Allergy Asthma Immunol. 2009 Nov;103(5):401-6. doi: 10.1016/S1081-1206(10)60359-6. PubMed PMID: 19927538.

Aceves SS, Bastian JF, Newbury RO, Dohil R. Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children. Am J Gastroenterol. 2007 Oct;102(10):2271-9; quiz 2280. doi: 10.1111/j.1572-0241.2007.01379.x. Epub 2007 Jun 20. PubMed PMID: 17581266.

Aceves SS, Newbury RO, Dohil R, Schwimmer J, Bastian JF. Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorder. J Clin Gastroenterol. 2007 Mar;41(3):252-6. doi: 10.1097/01.mcg.0000212639.52359.f1. PubMed PMID: 17426462.

Aceves SS, Newbury RO, Dohil R, Bastian JF, Broide DH. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Jan;119(1):206-12. doi: 10.1016/j.jaci.2006.10.016. PubMed PMID: 17208603.

Review Articles (Recent)

Aceves SS. Local Antigen Deposition in Eosinophilic Esophagitis: Implications for Immune Activation. Gastroenterology. 2019 Jul;157(1):17-20. doi: 10.1053/j.gastro.2019.05.044. Epub 2019 May 28. PubMed PMID: 31150607; PubMed Central PMCID: PMC6820847.

Spergel J, Aceves SS. Allergic components of eosinophilic esophagitis. J Allergy Clin Immunol. 2018 Jul;142(1):1-8. doi: 10.1016/j.jaci.2018.05.001. Review. PubMed PMID: 29980277; PubMed Central PMCID: PMC6083871.

Nhu QM, Aceves SS. Tissue Remodeling in Chronic Eosinophilic Esophageal Inflammation: Parallels in Asthma and Therapeutic Perspectives. Front Med (Lausanne). 2017;4:128. doi: 10.3389/fmed.2017.00128. eCollection 2017. Review. PubMed PMID: 28831387; PubMed Central PMCID: PMC5549614.

Aceves SS. Eosinophilic esophagitis. Immunol Allergy Clin North Am. 2015 Feb;35(1):145-59. doi: 10.1016/j.iac.2014.09.007. Epub 2014 Nov 21. Review. PubMed PMID: 25459582.

Collaborative Studies 

Kliewer KL, Venter C, Cassin AM, Abonia JP, Aceves SS, Bonis PA, Dellon ES, Falk GW, Furuta GT, Gonsalves N, Gupta SK, Hirano I, Kagalwalla A, Leung J, Mukkada VA, Spergel JM, Rothenberg ME. Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet?. J Allergy Clin Immunol. 2016 Apr;137(4):1011-1014. doi: 10.1016/j.jaci.2015.10.040. Epub 2015 Dec 24. PubMed PMID: 26725190; PubMed Central PMCID: PMC4826834.

Schoepfer AM, Panczak R, Zwahlen M, Kuehni CE, Coslovsky M, Maurer E, Haas NA, Alexander JA, Dellon ES, Gonsalves N, Hirano I, Leung J, Bussmann C, Collins MH, Newbury RO, De Petris G, Smyrk TC, Woosley JT, Yan P, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Blanchard C, Straumann A, Safroneeva E. How do gastroenterologists assess overall activity of eosinophilic esophagitis in adult patients?. Am J Gastroenterol. 2015 Mar;110(3):402-14. doi: 10.1038/ajg.2015.32. Epub 2015 Mar 3. PubMed PMID: 25732414.

Wen T, Dellon ES, Moawad FJ, Furuta GT, Aceves SS, Rothenberg ME. Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation. J Allergy Clin Immunol. 2015 Jan;135(1):187-97. doi: 10.1016/j.jaci.2014.08.043. Epub 2014 Oct 19. PubMed PMID: 25441638; PubMed Central PMCID: PMC4289084.

Schoepfer AM, Straumann A, Panczak R, Coslovsky M, Kuehni CE, Maurer E, Haas NA, Romero Y, Hirano I, Alexander JA, Gonsalves N, Furuta GT, Dellon ES, Leung J, Collins MH, Bussmann C, Netzer P, Gupta SK, Aceves SS, Chehade M, Moawad FJ, Enders FT, Yost KJ, Taft TH, Kern E, Zwahlen M, Safroneeva E. Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis. Gastroenterology. 2014 Dec;147(6):1255-66.e21. doi: 10.1053/j.gastro.2014.08.028. Epub 2014 Aug 23. PubMed PMID: 25160980; PubMed Central PMCID: PMC4425255.

Sleiman PM, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau K, Bredenoord AJ, Furuta GT, Spergel JM, Hakonarson H. GWAS identifies four novel eosinophilic esophagitis loci. Nat Commun. 2014 Nov 19;5:5593. doi: 10.1038/ncomms6593. PubMed PMID: 25407941; PubMed Central PMCID: PMC4238044.

Klinnert MD, Silveira L, Harris R, Moore W, Atkins D, Fleischer DM, Menard-Katcher C, Aceves S, Spergel JM, Franciosi JP, Furuta GT. Health-related quality of life over time in children with eosinophilic esophagitis and their families. J Pediatr Gastroenterol Nutr. 2014 Sep;59(3):308-16. doi: 10.1097/MPG.0000000000000451. PubMed PMID: 24897164; PubMed Central PMCID: PMC4141021.

Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, Burks AW, Chehade M, Collins MH, Dellon ES, Dohil R, Falk GW, Gonsalves N, Gupta SK, Katzka DA, Lucendo AJ, Markowitz JE, Noel RJ, Odze RD, Putnam PE, Richter JE, Romero Y, Ruchelli E, Sampson HA, Schoepfer A, Shaheen NJ, Sicherer SH, Spechler S, Spergel JM, Straumann A, Wershil BK, Rothenberg ME, Aceves SS. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011 Jul;128(1):3-20.e6; quiz 21-2. doi: 10.1016/j.jaci.2011.02.040. Epub 2011 Apr 7. Review. PubMed PMID: 21477849.