COVID-19 Updates

Visit UC San Diego's Coronavirus portal for the latest information for the campus community.

Helen Tighe, PhD

Tighe, Helen, PhD

Helen Tighe, PhD
Health Sciences Associate Clinical Professor 

Dr. Tighe received her BSc (Honors) in cellular pathology from the University of Bristol, England in 1983. She earned her PhD in immunology at the University of Cambridge in 1987.

Research Interests

  • Regulation, function and tolerance of autoreactive B cells
  • Stimulation of the immune system by DNA, including mechanism of action and application to autoimmune disease and cancer

Selected Publications

  1. Tighe H, Takabayashi K, Schwarz D, Van Nest G, Tuck S, Eiden JJ, Kagey-Sobotka A, Lichtenstein L, Spiegelberg H, Raz E. Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces allergenicity. J Allergy Clin Immunol, 106:124-34, 2000.
  2. Tighe H, Takabayashi K, Schwarz D, Marsden R, Beck L, Corbeil J., Richman D, Eiden J.J., Spiegelberg H, Raz E. Conjugation of protein to immunostimulatory DNA results in rapid, long-lasting and potent induction of cell mediated and humoral immunity. Eur J Immunol 30:1939-1947, 2000.
  3. Tighe H, Carson DA. Rheumatoid Factor. In Textbook of Rheumatology. 6th Ed. Kelley WN, Harris ED, Ruddy S, Sledge CB (eds) W.B. Saunders, Philadelphia, 2000.
  4. Widhopf GW, Brinson DC, Kipps TJ, Tighe H. Transgenic expression of a human polyreactive Ig expressed in chronic lymphocytic leukemia generates memory-type B cells that respond to nonspecific immune activation. J. Immunol. 172(4):2092-2099, 2004.
  5. Tighe H, Carson DA. Rheumatoid Factor. In Textbook of Rheumatology. 7th Ed. Kelley WN, Harris ED, Ruddy S, Sledge CB (eds) W.B. Saunders, Philadelphia, 2005.

More Tighe Publications via PubMed