Selected Publications
2021
Stanford SM, Diaz MA, Ardecky RJ, Zou J, Roosild T, Holmes ZJ, Nguyen
TP, Hedrick MP, Rodiles S, Guan A, Grotegut S, Santelli E, Chung TDY,
Jackson MR, Bottini N, Pinkerton AB. Discovery of Orally Bioavailable
Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine
Phosphatase. J Med Chem. 2021 May 13;64(9):5645-5653. doi:
10.1021/acs.jmedchem.0c02126. Epub 2021 Apr 29. PMID: 33914534.
Stanford SM, Collins M, Diaz MA, Holmes ZJ, Gries P, Bliss MR, Lodi A, Zhang V, Tiziani S, Bottini N. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy. J Cell Physiol. 2021 Feb 21. doi: 10.1002/jcp.30307. Epub ahead of print. PMID: 33615467.
2020
Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 2020 Oct 15;5(20):141868. doi: 10.1172/jci.insight.141868. PMID: 33055428.
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 Jun 26;6(26):eaba4353. doi: 10.1126/sciadv.aba4353. PMID: 32637608; PMCID: PMC7319753.
Highlighted in Natural Reviews Rheumatology:
Therapies targeting FLS and TNF can have synergistic effects (November 2020)
Used with permission from AAAS
Yang S, Svensson MND, Harder NHO, Hsieh WC, Santelli E, Kiosses WB, Moresco JJ, Yates JR 3rd, King CC, Liu L, Stanford SM, Bottini N. PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling. Sci Signal. 2020 Mar 17;13(623). pii: eaaw8130. doi: 10.1126/scisignal.aaw8130. PubMed PMID: 32184287.
Wen Y, Yang S, Wakabayashi K, Svensson MND, Stanford SM, Santelli E, Bottini N. RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. J Biol Chem. 2020 Mar 5. pii: jbc.RA119.011808. doi:10.1074/jbc.RA119.011808. [Epub ahead of print] PubMed PMID: 32139509.
2019
Mustelin T, Bottini N, Stanford SM. The Contribution of PTPN22 to Rheumatic
Disease. Arthritis Rheumatol. 2019 Apr;71(4):486-495. doi: 10.1002/art.40790. Epub 2019 Mar 2. Review. PubMed PMID: 30507064; PubMed Central PMCID: PMC6438733.
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr, M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. Ann Rheum Dis. 2019 Feb 26. doi: 10.1136/annrheumdis-2018-213799. PMID: 30808624
Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N. J Clin Invest. 2019 Jan 8. pii: 123267. doi: 10.1172/JCI123267. PMID:30620725
Highlighted in Nature Reviews Rheumatology:
How Treg cells lose FOXP3 (January 2019)
2018 
Mustelin T, Bottini N, Stanford SM. Arthritis Rheumatol. 2018 Dec 3. doi: 10.1002/art.40790. [Epub ahead of print] Review. PMID: 30507064
Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M. Nat Commun. 2018 Jul 6;9(1):2627. doi: 10.1038/s41467-018-05095-7. PMID: 29980684.
2017
Stanford SM, Bottini N. Trends Pharmacol Sci. 2017 Jun;38(6):524-540. doi: 10.1016/j.tips.2017.03.004. Epub 2017 Apr 12. Review.PMID: 28412041
Stanford SM, Aleshin AE, Zhang V, Ardecky RJ,Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.PMID: 28346406.
Highlighted in Nature Reviews Drug Discovery:
Protein tyrosine phosphatase inhibitor reverses diabetes (April 2017)
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1.PMID: 29057934.
2016
Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. JCI Insight. 2016 May 19;1(7). pii: e86580. PMID: 27275015.
Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442. PMID:26414708.
TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.
Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. Ann Rheum Dis. 2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6. PMID:25378349.
2015
Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS. J Immunol. 2015 Nov 15;195(10):4841-52. doi: 10.4049/jimmunol.1402654. Epub 2015 Oct 5. PMID: 26438525.
Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C. J Pathol. 2015 Dec;237(4):482-94. doi: 10.1002/path.4594. Epub 2015 Sep 1. PMID:26213100.
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616. PMID:25995222.
2014
Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. ACS Nano. 2014 Dec 23;8(12):12280-91. doi: 10.1021/nn504537b. Epub 2014 Nov 26. PMID:25415768.
Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. PLoS One. 2014 Feb 3;9(2):e86677. doi: 10.1371/journal.pone.0086677. eCollection 2014. PMID:24498279.
Bottini N, Peterson EJ. Annu Rev Immunol. 2014;32:83-119. doi: 10.1146/annurev-immunol-032713-120249. Epub 2013 Dec 18. Review.PMID:24364806.
2013
Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH Jr, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ. Immunity. 2013 Jul 25;39(1):111-22. doi: 10.1016/j.immuni.2013.06.013. Epub 2013 Jul 18. PMID:23871208.
Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. ACS Nano. 2013 Mar 26;7(3):1974-89. doi: 10.1021/nn400409h. Epub 2013 Feb 28. PMID:23413928.
Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. Arthritis Rheum. 2013 May;65(5):1171-80. doi: 10.1002/art.37872. PMID:23335101.
Bottini N, Firestein GS. Nat Rev Rheumatol. 2013 Jan;9(1):24-33. doi: 10.1038/nrrheum.2012.190. Epub 2012 Nov 13. Review. PMID:23147896.
Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. PNAS. 2012 Aug 28;109(35):13972-7. doi: 10.1073/pnas.1205028109. Epub 2012 Aug 13. PMID: 22891353.