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Publications

Selected Publications

2020
JCI Insight Oct 2020
PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis
Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. JCI Insight. 2020 Oct 15;5(20):141868. doi: 10.1172/jci.insight.141868. PMID: 33055428.
Science Advances June 2020
Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 Jun 26;6(26):eaba4353. doi: 10.1126/sciadv.aba4353. PMID: 32637608; PMCID: PMC7319753.

Highlighted in Natural Reviews Rheumatology: Therapies targeting FLS and TNF can have synergistic effects (November 2020)
Science Signalling March 2020Used with permission from AAAS
Yang S, Svensson MND, Harder NHO, Hsieh WC, Santelli E, Kiosses WB, Moresco JJ, Yates JR 3rd, King CC, Liu L, Stanford SM, Bottini N. PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling. Sci Signal. 2020 Mar 17;13(623). pii: eaaw8130. doi: 10.1126/scisignal.aaw8130. PubMed PMID: 32184287.
JBC March 2020
RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain
Wen Y, Yang S, Wakabayashi K, Svensson MND, Stanford SM, Santelli E, Bottini N. RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. J Biol Chem. 2020 Mar 5. pii: jbc.RA119.011808. doi:10.1074/jbc.RA119.011808. [Epub ahead of print] PubMed PMID: 32139509.

2019  Arthritis & Rheumatology 

The Contribution of PTPN22 to Rheumatic Disease
Mustelin T, Bottini N, Stanford SM. The Contribution of PTPN22 to Rheumatic
Disease. Arthritis Rheumatol. 2019 Apr;71(4):486-495. doi: 10.1002/art.40790. Epub 2019 Mar 2. Review. PubMed PMID: 30507064; PubMed Central PMCID: PMC6438733.
Annual of the Rheumatic Disease Feb 2019
PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr, M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. Ann Rheum Dis. 2019 Feb 26. doi: 10.1136/annrheumdis-2018-213799. PMID: 30808624
JCI Jan 2020
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N. J Clin Invest. 2019 Jan 8. pii: 123267. doi: 10.1172/JCI123267. PMID:30620725



Highlighted in Nature Reviews Rheumatology: How Treg cells lose FOXP3 (January 2019)


2018 Arthritis & Rheumatology 

The contribution of PTPN22 to rheumatological disease.
Mustelin T, Bottini N, Stanford SM. Arthritis Rheumatol. 2018 Dec 3. doi: 10.1002/art.40790. [Epub ahead of print] Review. PMID: 30507064

Nature Communications
Altered
thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.
 

Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M. Nat Commun. 2018 Jul 6;9(1):2627. doi: 10.1038/s41467-018-05095-7. PMID: 29980684.
2017Pharmacological Sciences June 2017

Targeting Tyrosine Phosphatases: Time to End the Stigma.
Stanford SM, Bottini N. Trends Pharmacol Sci. 2017 Jun;38(6):524-540. doi: 10.1016/j.tips.2017.03.004. Epub 2017 Apr 12. Review.PMID: 28412041
Nature Chemical Biology June 2017
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Stanford SM, Aleshin AE, Zhang V, Ardecky RJ,Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.PMID: 28346406.


Highlighted in Nature Reviews Drug Discovery: Protein tyrosine phosphatase inhibitor reverses diabetes (April 2017)

Nature Communications
PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1.PMID: 29057934.


2016 JCI Insight May 2016

Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. JCI Insight. 2016 May 19;1(7). pii: e86580. PMID: 27275015.
Arthritis & Rheumatology Feb 2016
Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442. PMID:26414708.
Annuals of the Rheumatic Diseases Jan 2016
TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.
Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. Ann Rheum Dis. 2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6. PMID:25378349.
2015   Journal of Immunology Nov 2015

Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS. J Immunol. 2015 Nov 15;195(10):4841-52. doi: 10.4049/jimmunol.1402654. Epub 2015 Oct 5. PMID: 26438525.


American Journal of Pathology
Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C. J Pathol. 2015 Dec;237(4):482-94. doi: 10.1002/path.4594. Epub 2015 Sep 1. PMID:26213100.


Translational Medicine
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616. PMID:25995222.


Highlighted in Nature Reviews Rheumatology: Manipulating the FLS 'proteoglycan switch' could offer a new approach to RA therapy (June 2015)
Highlighted in NIH Spotlight on Research: Discovery Opens Door to New Class of Medicines forRheumatoid Arthritis (September 2015)           


2014ACS Nano Dec 2014 

Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. ACS Nano. 2014 Dec 23;8(12):12280-91. doi: 10.1021/nn504537b. Epub 2014 Nov 26. PMID:25415768.
PLOS Feb 2014
Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. PLoS One. 2014 Feb 3;9(2):e86677. doi: 10.1371/journal.pone.0086677. eCollection 2014. PMID:24498279.
Annual Reviews Dec 2014
Bottini N, Peterson EJ. Annu Rev Immunol. 2014;32:83-119. doi: 10.1146/annurev-immunol-032713-120249. Epub 2013 Dec 18. Review.PMID:24364806.
2013Immunity July 2013 

Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH Jr, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ. Immunity. 2013 Jul 25;39(1):111-22. doi: 10.1016/j.immuni.2013.06.013. Epub 2013 Jul 18. PMID:23871208.

ACS Nano March 2013
Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. ACS Nano. 2013 Mar 26;7(3):1974-89. doi: 10.1021/nn400409h. Epub 2013 Feb 28. PMID:23413928.

Arthritis & Rheumatology
Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. Arthritis Rheum. 2013 May;65(5):1171-80. doi: 10.1002/art.37872. PMID:23335101.


Nature Reviews Jan 2013
Bottini N, Firestein GS. Nat Rev Rheumatol. 2013 Jan;9(1):24-33. doi: 10.1038/nrrheum.2012.190. Epub 2012 Nov 13. Review. PMID:23147896.


2012

Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. PNAS. 2012 Aug 28;109(35):13972-7. doi: 10.1073/pnas.1205028109. Epub 2012 Aug 13. PMID: 22891353.


Journal of Immunology Jun 2012
PTPN22 alters the development of regulatory T cells in the thymus.
Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA.
J Immunol. 2012 Jun 1;188(11):5267-75. doi: 10.4049/jimmunol.1200150. Epub 2012 Apr 25.
PMID:  22539785