Publications

Selected Publications

2019

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.

Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N.J Clin Invest. 2019 Jan 8. pii: 123267. doi: 10.1172/JCI123267. PMID:30620725

2018

The contribution of PTPN22 to rheumatological disease.

Mustelin T, Bottini N, Stanford SM.

Arthritis Rheumatol. 2018 Dec 3. doi: 10.1002/art.40790. [Epub ahead of print] Review.

PMID: 30507064

Altered

thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.

Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M. Nat Commun. 2018 Jul 6;9(1):2627. doi: 10.1038/s41467-018-05095-7. PMID: 29980684.

2017

Targeting Tyrosine Phosphatases: Time to End the Stigma.

Stanford SM, Bottini N.
Trends Pharmacol Sci. 2017 Jun;38(6):524-540. doi: 10.1016/j.tips.2017.03.004. Epub 2017 Apr 12. Review.PMID: 28412041

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Stanford SM, Aleshin AE, Zhang V, Ardecky RJ,Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.PMID: 28346406.

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.

Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1.PMID: 29057934.

2016

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.

Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS.

JCI Insight. 2016 May 19;1(7). pii: e86580. PMID: 27275015.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442. PMID:26414708.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.

Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N.

Ann Rheum Dis. 2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6. PMID:25378349.

2015

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.

Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS. J Immunol. 2015 Nov 15;195(10):4841-52. doi: 10.4049/jimmunol.1402654. Epub 2015 Oct 5. PMID: 26438525.

Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.

Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C. J Pathol. 2015 Dec;237(4):482-94. doi: 10.1002/path.4594. Epub 2015 Sep 1. PMID:26213100.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616. PMID:25995222.

2014

Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.

Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. ACS Nano. 2014 Dec 23;8(12):12280-91. doi: 10.1021/nn504537b. Epub 2014 Nov 26. PMID:25415768.

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. PLoS One. 2014 Feb 3;9(2):e86677. doi: 10.1371/journal.pone.0086677. eCollection 2014. PMID:24498279.

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.

Bottini N, Peterson EJ. Annu Rev Immunol. 2014;32:83-119. doi: 10.1146/annurev-immunol-032713-120249. Epub 2013 Dec 18. Review.PMID:24364806.

2013

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH Jr, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ. Immunity. 2013 Jul 25;39(1):111-22. doi: 10.1016/j.immuni.2013.06.013. Epub 2013 Jul 18. PMID:23871208.

Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance.

Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. ACS Nano. 2013 Mar 26;7(3):1974-89. doi: 10.1021/nn400409h. Epub 2013 Feb 28. PMID:23413928.

Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.

Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. Arthritis Rheum. 2013 May;65(5):1171-80. doi: 10.1002/art.37872. PMID:23335101.

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.

Bottini N, Firestein GS. Nat Rev Rheumatol. 2013 Jan;9(1):24-33. doi: 10.1038/nrrheum.2012.190. Epub 2012 Nov 13. Review. PMID:23147896.

2012

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. PNAS. 2012 Aug 28;109(35):13972-7. doi: 10.1073/pnas.1205028109. Epub 2012 Aug 13. PMID: 22891353.

PTPN22 alters the development of regulatory T cells in the thymus.

Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA.

J Immunol. 2012 Jun 1;188(11):5267-75. doi: 10.4049/jimmunol.1200150. Epub 2012 Apr 25.

PMID: 22539785

See full list of publications from PubMed