People

Stephanie Stanford, Ph.D., Assistant Professor of Medicine
ststanford@ucsd.edu

Dr. Stanford received her Ph.D. in Genetic, Molecular and Cellular Biology from the University of Southern California in 2010 and postdoctoral research training at the La Jolla Institute for Allergy and Immunology. Dr. Stanford was appointed as an Assistant Professor of Medicine at the University of California, San Diego in June 2016. Dr. Stanford's research is focused on the roles of protein tyrosine phosphatases (PTPs) in autoimmune and metabolic diseases. She is interested in understanding how genetic polymorphisms in genes encoding PTPs can mediate disease pathogenesis, developing new probes to study PTP activity, and in defining new drug targets within this family of enzymes.

See full list of Stanford publications from PubMed.

Angel Bottini, Ph.D., Assistant Project Scientist
angelbottini@ucsd.edu

I obtained my B.S degree in 2007 from UCLA majoring in Microbiology, Immunology and Molecular Genetics. Then I did my Ph.D training in Drug Discovery in the Pellecchia laboratory at the Sanford Burnham Prebys Medical Discovery Institute from 2009 to 2014 (The Pellecchia laboratory has moved to UC Riverside). I re-joined the Bottini laboratory in 2018 after my postdoctoral work focusing on non-receptor protein tyrosine phosphatase 14 (PTPN14) and its role in rheumatoid arthritis. My current research focuses on a subgroup of PTPs called phosphatase of regenerating liver (PRLs) and receptor PTP sigma (PTPRS). 

 

Eugenio Santelli, Ph.D., Assistant Project Scientist
esantelli@ucsd.edu

Eugenio obtained an M.S. degree in Industrial Chemistry from the University of Milan in 1993 and a Ph.D. in Structural Biology from the ETH Zurich in 2000. Subsequently, he moved to the Sanford Burnham Prebys Medical Discovery Institute as a postdoc, then as a Staff Scientist, and joined the Bottini Lab in 2015. He is currently focusing on the biophysical and biochemical side of several multidisciplinary efforts aimed at understanding and modulating the function of protein tyrosine phosphatases in the immune system and in fibroblast-like synoviocytes. He further plans to develop his career towards the applied biological sciences.

See full list of Santelli publications from PubMed.

 

Mattias Svensson, Ph.D., Assistant Project Scientist/Flow Cytometry Core Manager
msvensson@ucsd.edu

In 2009 I obtained my M.Sc. in pharmacy from the University of Gothenburg in Sweden. Later in February 2014 I completed my PhD in the group of Dr. Maria Bokarewa at the University of Gothenburg (Gothenburg, Sweden) with a thesis entitled “Tyrosine kinase Flt3/Flt3-ligand signaling in the modulation of immune responses in experimental arthritis”. I joined the Bottini laboratory as a post-doctoral fellow in March 2014. My research focuses on the involvement of protein tyrosine phosphatases (PTPs) in rheumatoid arthritis. With the use of animal models my focus is to better understand how PTPs influence susceptibility and development of rheumatoid arthritis. My goal is to become an independent researcher focusing on mechanisms that underlie autoimmune diseases and through my research help to better understand what makes some people susceptible to autoimmunity.

See full list of Svensson publication from PubMed.

Shen Yang, Ph.D., Postdoctoral Scholar
shy021@ucsd.edu

I obtained my Ph.D. degree from the Chinese Academy of Agricultural Sciences (CAAS) in 2014, and worked as a research associate in the Shanghai Veterinary Research Institute. I joined the Bottini laboratory as a post-doctoral fellow in December 2016. My projects are focused on the post-translational modifications of protein tyrosine phosphatases (PTPs). My goal is to become an independent investigator and focus on fundamental research with the goal to improve understanding and treatment of autoimmune diseases.

 

Dennis Wu, Ph.D., Postdoctoral Scholar
djwu@ucsd.edu

In 2009, I obtained my B.S. degree in Biochemistry and Cell Biology from the University of California, San Diego. I then did my Ph.D. training in Dr. Iannis Adamopoulos’ laboratory at the University of California, Davis, studying mechanisms of autophagy-related proteins in the bone destruction process. I joined the Bottini laboratory in August 2016. My research investigates the role of protein tyrosine phosphatases (PTPs) in rheumatoid arthritis. With the use of both animal models and cell culture systems, I aim to better understand how PTPs influence susceptibility to and development of rheumatoid arthritis. My goal is to become an independent researcher focused on translational medical research for rheumatic diseases.

See full list of Wu publications from PubMed.

 

Wan-Chen Hsieh, Ph.D., Postdoctoral Scholar
whsieh@ucsd.edu

I obtained my Ph.D. degree from National Defense Medical Center in Taiwan in 2015. I carried my thesis research in Dr. Ming-Zong Lai’s laboratory at Academia Sinica, Taiwan focusing on the role in XIAP in dectin-1-mediated innate responses. After graduation, I continued in the same laboratory focusing on how XIAP affects regulatory T-cell's function. I joined Dr. Bottini’s laboratory as a postdoctoral researcher in 2018 to study the pathogenesis of rheumatoid arthritis, with the focus on the interaction between genetic and environmental factors. My goal is to become an independent researcher focused on mechanisms of diseases and help developed of innovative treatments for autoimmune diseases.

 

Martina Zoccheddu, M.S., Staff Research Associate
mzoccheddu@ucsd.edu

I obtained my M.S. degree cum laude in Medical Biotechnology in 2015 at the University of Sassari, Italy. I joined the Bottini laboratory in May 2017. My research is focused on the role of PTPRS in rheumatoid arthritis. My goal is to pursue a Ph.D. in Immunology or Biochemistry focusing my studies on chronic systemic autoimmune diseases.

.

Michael Diaz, M.S., Staff Research Associate 
mad053@ucsd.edu

I graduated from Azusa Pacific University in 2013 with a Bachelor’s Degree in Biology. I then completed a M.S. degree in Pathology at USC in the Epstein lab, and graduated in 2017. 

I joined the Bottini laboratory in 2017. I am researching the role of protein tyrosine phosphatases in cardiovascular diseases. My goal is to attend graduate school and pursue a career in translational science with a focus on identifying new therapies. 

Benjamin Van Espen, M.S., Staff Research Associate
bvanespen@ucsd.edu

I obtained my M.S. degree in Biomedical Sciences in 2014 from the University of Mons in Belgium. After spending two years working on Metabolomics studies of Diabetic Kidney Disease in the group of Dr. Kumar Sharma at UCSD, I joined the Bottini laboratory in 2017.

My research focuses on the mechanism of action of PTPN22 in rheumatoid arthritis. My goal is to pursue a Ph.D. and then a career in academic research, becoming an independent investigator focusing on discovery and development of innovative treatments for human diseases.

Yutao Wen, UCSD BS/MS Student

y9wen@ucsd.edu

I’m a third-year undergrad at UCSD majoring Molecular Biology and working towards the contiguous BSMS program. I joined the Bottini Lab in November 2017 and work under the supervision of Eugenio, participating in projects related to rheumatoid arthritis and systemic sclerosis. My hope is to gain research experience and prepare for Ph.D.

Joseph Chang, UCSD BS/MS Student

joc035@ucsd.edu

I'm currently finishing up my Bachelor's Degree in Molecular Biology at UCSD, and then transitioning into the Master's program for a Master's in Biology also at UCSD, Class of 2019. I joined the Bottini laboratory in January 2018 and am working with Michael to research the role of protein tyrosine phosphatases in cancer. After completion of the graduate program, I hope to pursue cancer research with an emphasis on pharmacology.

Daniel Lee, UCSD BS/MS Student

Dwl013@ucsd.edu

I'm currently finishing up my Bachelor's Degree in Biology at UCSD, and then transitioning into the Master's program also at UCSD. I joined the lab March 2018 and am currently working with Dr. Dennis Wu to study the role of protein tyrosine phosphatases in rheumatoid arthritis. I seek to pursue either an MD or PhD in the future.

Ruiyuan Zhang, Undergraduate Research Assistant 

ruz063@ucsd.edu‎

I am a third-year undergraduate major in Biochemistry and Cell Biology. I joined the Bottini laboratory in January 2018. I am currently working with Dr. Santelli assessing protein-protein interactions relevant to systemic sclerosis. I hope to gain some lab experience in preparation to pursuing a Ph.D. in biomedical science.