People

Stephanie Stanford, Ph.D., Assistant Professor of Medicine
ststanford@health.ucsd.edu

Dr. Stanford received her Ph.D. in Genetic, Molecular and Cellular Biology from the University of Southern California in 2010 and postdoctoral research training at the La Jolla Institute for Allergy and Immunology. Dr. Stanford was appointed as an Assistant Professor of Medicine at the University of California, San Diego in June 2016. Dr. Stanford's research is focused on the roles of protein tyrosine phosphatases (PTPs) in autoimmune and metabolic diseases. She is interested in understanding how genetic polymorphisms in genes encoding PTPs can mediate disease pathogenesis, developing new probes to study PTP activity, and in defining new drug targets within this family of enzymes.

See full list of Stanford publications from PubMed.

Angel Bottini, Ph.D., Assistant Project Scientist
angelbottini@health.ucsd.edu

I obtained my B.S degree in 2007 from UCLA majoring in Microbiology, Immunology and Molecular Genetics. Then I did my Ph.D training in Drug Discovery in the Pellecchia laboratory at the Sanford Burnham Prebys Medical Discovery Institute from 2009 to 2014 (The Pellecchia laboratory has moved to UC Riverside). I re-joined the Bottini laboratory in 2018 after my postdoctoral work focusing on non-receptor protein tyrosine phosphatase 14 (PTPN14) and its role in rheumatoid arthritis. My current research focuses on a subgroup of PTPs called phosphatase of regenerating liver (PRLs) and receptor PTP sigma (PTPRS). 

Eugenio Santelli, Ph.D., Assistant Project Scientist
esantelli@health.ucsd.edu

Eugenio obtained an M.S. degree in Industrial Chemistry from the University of Milan in 1993 and a Ph.D. in Structural Biology from the ETH Zurich in 2000. Subsequently, he moved to the Sanford Burnham Prebys Medical Discovery Institute as a postdoc, then as a Staff Scientist, and joined the Bottini Lab in 2015. He is currently focusing on the biophysical and biochemical side of several multidisciplinary efforts aimed at understanding and modulating the function of protein tyrosine phosphatases in the immune system and in fibroblast-like synoviocytes. He further plans to develop his career towards the applied biological sciences.

See full list of Santelli publications from PubMed.

Shen Yang, Ph.D., Postdoctoral Scholar
shy021@health.ucsd.edu

I obtained my Ph.D. degree from the Chinese Academy of Agricultural Sciences (CAAS) in 2014, and worked as a research associate in the Shanghai Veterinary Research Institute. I joined the Bottini laboratory as a post-doctoral fellow in December 2016. My projects are focused on the post-translational modifications of protein tyrosine phosphatases (PTPs). My goal is to become an independent investigator and focus on fundamental research with the goal to improve understanding and treatment of autoimmune diseases.

 

Myungja Ro, Ph.D., Postdoctoral Scholar
myro@health.ucsd.edu

I obtained my Ph.D. degree in biotechnology from Korea University in 2018. My Ph.D. thesis was focused on the role of the Leukotriene B4 receptor 2 in the development of asthma. I joined the Bottini laboratory as a postdoctoral researcher in August 2019. My research focuses on the role of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in rheumatoid arthritis. My goal is to become an independent researcher heading a laboratory focused on mechanisms of immune-mediated diseases and contribute to the discovery of new treatments for these diseases.

Wan-Chen Hsieh, Ph.D., Postdoctoral Scholar
whsieh@health.ucsd.edu

I obtained my Ph.D. degree from National Defense Medical Center in Taiwan in 2015. I carried my thesis research in Dr. Ming-Zong Lai’s laboratory at Academia Sinica, Taiwan focusing on the role in XIAP in dectin-1-mediated innate responses. After graduation, I continued in the same laboratory focusing on how XIAP affects regulatory T-cell's function. I joined Dr. Bottini’s laboratory as a postdoctoral researcher in 2018 to study the pathogenesis of rheumatoid arthritis, with the focus on the interaction between genetic and environmental factors. My goal is to become an independent researcher focused on mechanisms of diseases and help developed of innovative treatments for autoimmune diseases.

Sho Sendo, M.D., Ph.D., Visiting Scholar
ssendo@health.ucsd.edu

I obtained my M.D. degree in 2006 from the University of Toyama in Japan followed by a residency and fellowship in rheumatology. In 2017, I obtained my Ph.D. from Dr. Akio Morinobu’s laboratory at the Kobe University Graduate School of Medicine, focusing on the role of regulatory myeloid cells in rheumatoid arthritis (RA)-associated interstitial lung disease. I joined the Bottini laboratory in August 2019. My research focuses on the role of protein tyrosine phosphatases (PTPs) in RA synoviocytes. My goal is to become an independent researcher focused on translational rheumatological research.

Martina Zoccheddu, M.S., Staff Research Associate
mzoccheddu@health.ucsd.edu

I obtained my M.S. degree cum laude in Medical Biotechnology in 2015 at the University of Sassari, Italy. I joined the Bottini laboratory in May 2017. My research is focused on the role of PTPRS in rheumatoid arthritis. My goal is to pursue a Ph.D. in Immunology or Biochemistry focusing my studies on chronic systemic autoimmune diseases.

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Michael Diaz, M.S., Staff Research Associate 
mad053@health.ucsd.edu

I graduated from Azusa Pacific University in 2013 with a Bachelor’s Degree in Biology. I then completed a M.S. degree in Pathology at USC in the Epstein lab, and graduated in 2017. 

I joined the Bottini laboratory in 2017. I am researching the role of protein tyrosine phosphatases in cardiovascular diseases. My goal is to attend graduate school and pursue a career in translational science with a focus on identifying new therapies. 

 

Megan Lee, Staff Research Associate
mcl001@health.ucsd.edu

In May of 2019, I graduated from the University of San Diego with a Bachelor’s in Biophysics. I joined the Bottini lab that following August. My research is focused on understanding the role of tyrosine phosphatases in rheumatoid arthritis and studying their potential for therapeutic targeting. In the future, I hope to obtain an MD degree.

Denise Beckmann, Ph.D. Staff Research Associate
dbeckman@health.ucsd.edu

I obtained my PhD from the University Hospital Muenster in 2019 in the Pap laboratory at the Institute of Musculoskeletal Medicine, which focuses on expression and regulation of several molecules that are associated with the aggressive-invasive behavior of rheumatoid fibroblast-like synoviocytes (FLS). For my Thesis, I investigated the function of FLS intercellular communication mechanisms, with a particular focus on cadherin-11-dependent cell-to-cell contacts and their role in rheumatoid arthritis pathogenesis. I joined the Bottini laboratory in November 2019. My research focuses on the role of protein tyrosine phosphatases (PTPs) in rheumatoid arthritis. My goal is to become an independent researcher in the field of inflammatory diseases.

Andrew Wilson, Staff Research Associate
arwilson@health.ucsd.edu

I graduated from UCSD with a degree in Biochemistry and Cell Biology and joined the Bottini laboratory in 2019. I manage the laser capture core and perform laser-capture genomic studies on various autoimmune disease specimens under the supervision of Dr. Stephanie Stanford. I plan to pursue a master degree in bioinformatics and continue to work with sequencing technologies.

Ruiyuan Zhang, UCSD BS/MS Student
ruz063@health.ucsd.edu‎

I am a third-year undergraduate major in Biochemistry and Cell Biology. I joined the Bottini laboratory in January 2018. I am currently working with Dr. Santelli assessing protein-protein interactions relevant to systemic sclerosis. I hope to gain some lab experience in preparation to pursuing a Ph.D. in biomedical science.


Zachary Holmes, Undergraduate Research Assistant
zholmes@health.ucsd.edu

I'm currently finishing the last year of my undergraduate degree in Molecular Biology here at UCSD before transitioning into a Master's program. I joined the laboratory in June of 2019, and I am currently conducting research under Dr. Stanford’s supervision on small-molecule inhibitors of the LMPTP, class II protein tyrosine phosphatase. After finishing my Master's program I hope to pursue a career in medical research with an emphasis on molecular biology approaches.

Tiffany Nguyen, Undergraduate Research Assistant
tpn047@health.ucsd.edu

I am a third-year undergrad majoring in Biochemistry and Cell Biology and I hope to transition into the BS/MS program after graduating. I joined the lab in July 2019 and I am currently studying the role of protein tyrosine phosphatases in prostate cancer under Dr. Stanford’s supervision. I hope to gain research experience to further pursue a Ph.D. in clinical pharmacology.

 

May Tun, Undergraduate Research Assistant
mttun@health.ucsd.edu

I am currently a third year at UCSD, majoring in Biochemistry and Cell Biology. I joined the Bottini Lab in June 2019 to gain experience working in a research lab as a scientist, and plan to join the Contiguous BS/MS Program. I work under Dr. Santelli's supervision, and my research project focuses on the regulation of PTPN2 in immune cells.