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People

Fabio Forti

Fabio Forti, Ph.D. Visiting Professor
fforti@health.ucsd.edu

I received my BS in Chemistry (1992), MS in Analytical Chemistry (1995), and PhD in Biochemistry (2001) from the Institute of Chemistry-University of Sao Paulo, Brazil. Then I underwent postdoctoral training at the Salk Institute, the University of Sao Paulo, the Sanford Burnham Prebys Institute and the Chemistry and Biochemistry Department of UC San Diego. In 2009 I was appointed as Assistant Professor of Biochemistry and Molecular Biology at the Department of Biochemistry, Institute of Chemistry, University of Sao Paulo-Brazil and promoted to Associate Professor in 2016 (see http://www3.iq.usp.br/pessoas_view.php?idDocente=32&idioma=us). My research interests include signal transduction by Dual Tyrosine Phosphatases and Small Rho GTPases in the control of genomic stability and DNA repair of cells under conditions of genotoxic/oxidative stress. I joined the Bottini lab in Feb 2020 as a Visiting Professor to collaborate on studies on the regulation of PTPN2 and how this phosphatase regulates signaling pathways in immune cells.

See full list of Dr. Forti’s publications on PubMed.

Angel Bottini

Angel Bottini, Ph.D., Assistant Project Scientist
angelbottini@health.ucsd.edu

I obtained my B.S degree in 2007 from UCLA majoring in Microbiology, Immunology and Molecular Genetics. Then I did my Ph.D training in Drug Discovery in the Pellecchia laboratory at the Sanford Burnham Prebys Medical Discovery Institute from 2009 to 2014 (The Pellecchia laboratory has moved to UC Riverside). I re-joined the Bottini laboratory in 2018 after my postdoctoral work focusing on non-receptor protein tyrosine phosphatase 14 (PTPN14) and its role in rheumatoid arthritis. My current research focuses on a subgroup of PTPs called phosphatase of regenerating liver (PRLs) and receptor PTP sigma (PTPRS). 

Favorite Book/Movie: Pride and Prejudice

Eugenio Santelli

Eugenio Santelli, Ph.D., Assistant Project Scientist
esantelli@health.ucsd.edu

I obtained a M.S. degree in Industrial Chemistry from the University of Milan in 1993 and a Ph.D. in Structural Biology from the ETH Zurich in 2000. Subsequently, I moved to the Sanford Burnham Prebys Medical Discovery Institute as a postdoc and then as a Staff Scientist before joining the Bottini Lab in 2015. I am currently focusing on the biophysical and biochemical side of several multidisciplinary efforts aimed at understanding and modulating the function of protein tyrosine phosphatases in the immune system and in fibroblast-like synoviocytes. I also plan to develop my career towards the applied biological sciences.

See full list of Dr. Santelli's publications on PubMed.

Shen Yang

Shen Yang, Ph.D., Assistant Project Scientist
shy021@health.ucsd.edu

I obtained my Ph.D. degree from the Chinese Academy of Agricultural Sciences (CAAS) in 2014, and worked as a research associate in the Shanghai Veterinary Research Institute. I joined the Bottini laboratory as a post-doctoral fellow in December 2016 and was promoted to Assistant Project Scientist in 2020. My projects are focused on the post-translational modifications of protein tyrosine phosphatases (PTPs). My goal is to become an independent investigator and focus on fundamental research with the goal to improve understanding and treatment of autoimmune diseases.

Personal Motto: "Seek victory while keeping performance stable."

Myungia Ro

Myungja Ro, Ph.D., Postdoctoral Scholar
myro@health.ucsd.edu

I obtained my Ph.D. degree in biotechnology from Korea University in 2018. My Ph.D. thesis was focused on the role of the Leukotriene B4 receptor 2 in the development of asthma. I joined the Bottini laboratory as a postdoctoral researcher in August 2019. My research focuses on the role of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in rheumatoid arthritis. My goal is to become an independent researcher heading a laboratory focused on mechanisms of immune-mediated diseases and contribute to the discovery of new treatments for these diseases.

Ke Wang.

Ke Wang, Ph.D., Postdoctoral Scholar
kew002@health.ucsd.edu

I obtained my Ph.D. in Immunology from Peking University in July 2018 with a thesis focused on molecular mechanisms of T lymphocytes development and differentiation. I became a postdoctoral scholar at UCSD in September 2018 and joined the Bottini laboratory in June 2020. My current research focuses on the role of protein tyrosine phosphatases (PTPs) in autoimmune diseases. My goal is to become an independent investigator in immunology focusing on the understanding of the adaptive immune response in autoimmune diseases.
Yang Dai

Yang Dai, Ph.D., Visiting Scholar
ydai@bri-sc.org

I received my Ph.D. degree in 2002 from the Memorial University of Newfoundland in Canada and completed my postdoctoral training in T cell biology and Immune Regulation at the La Jolla Institute for Immunology and the Torrey Pines Institute for Molecular Studies in San Diego, California. I am currently appointed as an Associate Professor at the Biomedical Research Institute of Southern California, San Diego. My research focuses on T-cell-mediated autoimmune disease, particularly Type 1 diabetes (T1D). My lab has identified one special type of secreted microvesicles or exosomes that contain endogenous retrovirus (ERV) antigens as a novel autoimmune trigger.

Madoka Fujisawa
Madoka Fujisawa, M.D., Ph.D.,Visiting Scholar
mfujisawa@health.ucsd.edu

I obtained my M.D. in 2010 from the University of Tokyo in Japan where I also completed my residency and Nephrology fellowship. I received my Ph.D. in the Division of Nephrology and Endocrinology from the University of Tokyo in 2018, focusing on atypical HUS (hemolytic uremic syndrome). I joined the Bottini lab in November 2020 as a Visiting Scholar, working on the study of signal transduction pathways relevant to autoimmune diseases. I hope to gain research experience and become an independent researcher.

                                       Personal Motto: "Eat well, sleep well."
Martina Zoccheddu

Martina Zoccheddu, M.S., Staff Research Associate
mzoccheddu@health.ucsd.edu

I obtained my M.S. degree cum laude in Medical Biotechnology in 2015 at the University of Sassari, Italy. I joined the Bottini laboratory in May 2017. My research is focused on the role of PTPRS in rheumatoid arthritis. My goal is to pursue a Ph.D. in Immunology or Biochemistry focusing my studies on chronic systemic autoimmune diseases.

 Megan Lee

Megan Lee, Staff Research Associate
mcl001@health.ucsd.edu

In May of 2019, I graduated from the University of San Diego with a Bachelor’s in Biophysics. I joined the Bottini lab that following August. My research is focused on understanding the role of tyrosine phosphatases in rheumatoid arthritis and studying their potential for therapeutic targeting. In the future, I hope to obtain an MD degree.

Anna Belongia
Anna Belongia, Staff Research Associate
abelongia@health.ucsd.edu

I graduated from the University of Vermont with a degree in Biochemistry in May 2020, where my work focused on investigating the alterations of the STK11 gene, which is associated with non-small cell lung carcinoma. I joined the Bottini laboratory that following September. I manage the laser capture core and perform laser-capture genomic studies on various autoimmune disease specimens under the supervision of Dr. Stephanie Stanford. My goal is to gain diverse experience as I prepare to pursue a Ph.D.

                                      Favorite Movie: O Brother, Where Art Thou
Colton Sanders
Colton Sanders, Staff Research Associate
cmsanders@health.ucsd.edu

I obtained my Bachelor’s degrees in Biology and Chemistry from the University of North Carolina at Chapel Hill in 2020. I joined the Bottini/Stanford lab in August 2020 following my graduation. Under the direction of Dr. Stephanie Stanford, I am working to study the role of LMPTP in the development of cardiac fibrosis. My goal is to continue gaining practical research experience prior to pursuing a Ph.D.

                                      Favorite Movie: The Devil Wears Prada
Ruiyuan Zhang

Ruiyuan Zhang, Staff Research Associate
ruz063@health.ucsd.edu‎

I joined the Bottini lab in January of 2018 as a BS/MS student and graduated in August of 2020. Afterward, I was recruited to the lab as an SRA1 to work on project focused on the role of PTPs in fibrosis and scleroderma.  For my future, I would like to obtain a PhD in translational medicine and pursue a scientific career in the pharmaceutical/biotech industry.


Zachary Holmes

Zachary Holmes, UCSD BS/MS Student
zholmes@health.ucsd.edu

I finished my undergraduate at UCSD in 2020 with a degree in Molecular Biology. I joined the Bottini Lab in 2019, and I am currently an MS student under the supervision of Dr. Stanford. I am researching small-molecule inhibitors of LMPTP, and the role of LMPTP in obesity-induced adipogenesis and adipocyte hypertrophy. Once I finish my Master's degree, I hope to begin a career in medical research, hopefully pursuing a similar path to what I've been working on since I've joined the Bottini Lab.

Personal Motto: "Remember to be kind to yourself, just as you would be to someone you love."

Tiffany Nguyen

Tiffany Nguyen, UCSD BS/MS Student
tpn047@health.ucsd.edu

I received my Bachelor's degree in Biochemistry and Cell Biology from UCSD in June 2020 and am currently an M.S. student in the Bottini Lab. I joined the lab in July 2019. Currently, I am exploring the role of LMPTP in prostate cancer and cardiac fibrosis under Dr. Stanford’s guidance and supervision. I hope to become a physician-scientist in the future.

May Tun 

May Tun, UCSD BS/MS Student
mttun@ucsd.edu

I am currently an undergraduate at UCSD majoring in Biochemistry and Cell Biology. I joined the Bottini Lab in June 2019 to gain experience working in a research lab as a scientist, and plan to join the Contiguous BS/MS Program. I work under Dr. Santelli's supervision, and my research project focuses on the regulation of PTPN2 in immune cells.

Irene Choi
Irene Choi, Undergraduate Research Assistant
ivchoi@ucsd.edu

I am an undergraduate student majoring in Molecular Biology. I joined the Bottini Lab in September 2019 and am studying the post-translational regulation of the PTPN22 protein under Dr. Yang. In the future, I hope to earn my Master's degree in Molecular Biology then pursue a career in the biotech industry.

                                      Favorite Artwork: Canyon Mountains by Wayne Thiebaud
Longyue Wang
Longyue Wang, Undergraduate Research Assistant
low002@ucsd.edu

I am currently an undergraduate student at UCSD majoring in Molecular and Cell biology and Clinical Psychology. I joined the Bottini laboratory in June 2020 and work on the regulation and function of PTPRS under Dr. Santelli's supervision. I hope to continue as a BS/MS student after graduation and wish to pursue a Ph.D. degree in biological science after that.

Favorite Artwork: Claude Monet's Woman with a Parasol - Madame Monet and Her Son.

Jalin Silas Xu
Jalin Silas Xu, Undergraduate Research Assistant 
jix007@ucsd.edu

I am an undergraduate student majoring in Molecular and Cell Biology. I joined the Bottini Lab in July 2020, and I'm studying the allosteric regulation mechanism of RPTPα phosphatase activity and similar mechanisms in other RPTPs under Dr. Santelli's supervision. I hope to gain research experience, transition into the BS/MS program, and then pursue a Ph.D. degree in the future.
Sophie Hao, Undergraduate Research Assistant
yfhao@ucsd.edu

I am an undergraduate student double majoring in Molecular and Cell Biology and Human Developmental Sciences. I joined the Bottini Lab in November 2020 studying the role of PRL1 and of its interaction with SRC in the pathogenesis of systemic sclerosis under Dr. Santelli's supervision. I hope to earn my Master's degree through the contiguous BS/MS program and continue doing research afterward.
 
                                      Favorite Artwork: Chopin's Ballade No. 1 in G minor, Op. 23