COVID-19 Updates

Visit UC San Diego's Coronavirus portal for the latest information for the campus community.

People

Angel Bottini

Angel Bottini, Ph.D., Assistant Project Scientist
angelbottini@health.ucsd.edu

I obtained my B.S degree in 2007 from UCLA majoring in Microbiology, Immunology and Molecular Genetics. Then I did my Ph.D. training in Drug Discovery in the Pellecchia laboratory at the Sanford Burnham Prebys Medical Discovery Institute from 2009 to 2014 (The Pellecchia laboratory has moved to UC Riverside). I re-joined the Bottini laboratory in 2018 after my postdoctoral work focusing on non-receptor protein tyrosine phosphatase 14 (PTPN14) and its role in rheumatoid arthritis. My current research focuses on a subgroup of PTPs called phosphatase of regenerating liver (PRLs) and receptor PTP sigma (PTPRS). 

Favorite Book/Movie: Pride and Prejudice

Eugenio Santelli

Eugenio Santelli, Ph.D., Assistant Project Scientist
esantelli@health.ucsd.edu

I obtained a M.S. degree in Industrial Chemistry from the University of Milan in 1993 and a Ph.D. in Structural Biology from the ETH Zurich in 2000. Subsequently, I moved to the Sanford Burnham Prebys Medical Discovery Institute as a postdoc and then as a Staff Scientist before joining the Bottini Lab in 2015. I am currently focusing on the biophysical and biochemical side of several multidisciplinary efforts aimed at understanding and modulating the function of protein tyrosine phosphatases in the immune system and in fibroblast-like synoviocytes. I also plan to develop my career towards the applied biological sciences.

See full list of Dr. Santelli's publications on PubMed.

Shen Yang

Shen Yang, Ph.D., Assistant Project Scientist
shy021@health.ucsd.edu

I obtained my Ph.D. degree from the Chinese Academy of Agricultural Sciences (CAAS) in 2014, and worked as a research associate in the Shanghai Veterinary Research Institute. I joined the Bottini laboratory as a post-doctoral fellow in December 2016 and was promoted to Assistant Project Scientist in 2020. My projects are focused on the post-translational modifications of protein tyrosine phosphatases (PTPs). My goal is to become an independent investigator and focus on fundamental research with the goal to improve understanding and treatment of autoimmune diseases.

Personal Motto: "Seek victory while keeping performance stable."

Myungia Ro

Myungja Ro, Ph.D., Postdoctoral Scholar
myro@health.ucsd.edu

I obtained my Ph.D. degree in biotechnology from Korea University in 2018. My Ph.D. thesis was focused on the role of the Leukotriene B4 receptor 2 in the development of asthma. I joined the Bottini laboratory as a postdoctoral researcher in August 2019. My research focuses on the role of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in rheumatoid arthritis. My goal is to become an independent researcher heading a laboratory focused on mechanisms of immune-mediated diseases and contribute to the discovery of new treatments for these diseases.

Ke Wang.

Ke Wang, Ph.D., Postdoctoral Scholar
kew002@health.ucsd.edu

I obtained my Ph.D. in Immunology from Peking University in July 2018 with a thesis focused on molecular mechanisms of T lymphocytes development and differentiation. I became a postdoctoral scholar at UCSD in September 2018 and joined the Bottini laboratory in June 2020. My current research focuses on the role of protein tyrosine phosphatases (PTPs) in autoimmune diseases. My goal is to become an independent investigator in immunology focusing on the understanding of the adaptive immune response in autoimmune diseases.
Jaeyeon Kim
Jaeyeon Kim, Ph.D., Postdoctoral Scholar
jak020@health.ucsd.edu

I earned my Ph.D. in Biomedical Science from CHA University, South Korea in February 2021. I joined Dr. Bottini's lab as a postdoctoral researcher that following June. During the course of my M.S. and Ph.D. degrees, my research focused on the molecular mechanisms of protein tyrosine phosphatase type IVA 1 (PTP4A1; PRL-1) in mesenchymal stem cells in chronic liver and autoimmune diseases. Now, my research investigates the molecuar mechanisms of receptor PTP sigma (PTPRS) in rheumatoid synoviocytes. I hope to become a  university professor focused on mechanisms of disease and translational research in chronic diseases.
Yang Dai

Yang Dai, Ph.D., Visiting Scholar
ydai@bri-sc.org

I received my Ph.D. degree in 2002 from the Memorial University of Newfoundland in Canada and completed my postdoctoral training in T cell biology and Immune Regulation at the La Jolla Institute for Immunology and the Torrey Pines Institute for Molecular Studies in San Diego, California. I am currently appointed as an Associate Professor at the Biomedical Research Institute of Southern California, San Diego. My research focuses on T-cell-mediated autoimmune disease, particularly Type 1 diabetes (T1D). My lab has identified one special type of secreted microvesicles or exosomes that contain endogenous retrovirus (ERV) antigens as a novel autoimmune trigger.

Madoka Fujisawa
Madoka Fujisawa, M.D., Ph.D.,Visiting Scholar
mfujisawa@health.ucsd.edu

I obtained my M.D. in 2010 from the University of Tokyo in Japan where I also completed my residency and Nephrology fellowship. I received my Ph.D. in the Division of Nephrology and Endocrinology from the University of Tokyo in 2018, focusing on atypical HUS (hemolytic uremic syndrome). I joined the Bottini lab in November 2020 as a Visiting Scholar, working on the study of signal transduction pathways relevant to autoimmune diseases. I hope to gain research experience and become an independent researcher.

                                       Personal Motto: "Eat well, sleep well."
Brianna Hurysz
Brianna Hurysz, Graduate Student
bhurysz@health.ucsd.edu
I am currently pursuing my Ph.D. in Biomedical Sciences at UCSD and am co-advised by Drs. Nunzio Bottini and Stephanie Stanford. I obtained a B.S. in Biochemistry at Hobart and William Smith Colleges in 2020. I joined the Bottini & Stanford lab in the summer of 2021, and my project involves studying the potential of drugging PTPRS as a therapeutic for various pathologies including rheumatoid arthritis, multiple sclerosis, and spinal cord injury.
Martina Zoccheddu

Martina Zoccheddu, M.S., Staff Research Associate
mzoccheddu@health.ucsd.edu

I obtained my M.S. degree cum laude in Medical Biotechnology in 2015 at the University of Sassari, Italy. I joined the Bottini laboratory in May 2017. My research is focused on the role of PTPRS in rheumatoid arthritis. My goal is to pursue a Ph.D. in Immunology or Biochemistry focusing my studies on chronic systemic autoimmune diseases.

Anna Belongia
Anna Belongia, Staff Research Associate
abelongia@health.ucsd.edu

I graduated from the University of Vermont with a degree in Biochemistry in May 2020, where my work focused on investigating the alterations of the STK11 gene, which is associated with non-small cell lung carcinoma. I joined the Bottini laboratory that following September. I manage the laser capture core and perform laser-capture genomic studies on various autoimmune disease specimens under the supervision of Dr. Stephanie Stanford. My goal is to gain diverse experience as I prepare to pursue a Ph.D.

                                      Favorite Movie: O Brother, Where Art Thou
Colton Sanders
Colton Sanders, Staff Research Associate
cmsanders@health.ucsd.edu

I obtained my Bachelor’s degrees in Biology and Chemistry from the University of North Carolina at Chapel Hill in 2020. I joined the Bottini/Stanford lab in August 2020 following my graduation. Under the direction of Dr. Stephanie Stanford, I am working to study the role of LMPTP in the development of cardiac fibrosis. My goal is to continue gaining practical research experience prior to pursuing a Ph.D.

                                      Favorite Movie: The Devil Wears Prada
Zachary Holmes

Zachary Holmes, Staff Research Associate
zholmes@health.ucsd.edu

I received my Bachelor's degree in Molecular Biology from UCSD and finished my M.S. in Biology doing research with Dr. Stanford on LMPTP-related drug discovery and adipocyte biology. After receiving my M.S. I began working with Dr. Bottini to continue my research on PTPs as an SRA. My goal is to continue gaining research experience before pursuing a Ph.D.

Personal Motto: "Remember to be kind to yourself, just as you would be to someone you love."

Tiffany Nguyen

Tiffany Nguyen, UCSD BS/MS Student
tpn047@health.ucsd.edu

I received my Bachelor's degree in Biochemistry and Cell Biology from UCSD in June 2020 and am currently an M.S. student in the Bottini Lab. I joined the lab in July 2019. Currently, I am exploring the role of LMPTP in prostate cancer and cardiac fibrosis under Dr. Stanford’s guidance and supervision. I hope to become a physician-scientist in the future.

May Tun 

May Tun, UCSD BS/MS Student
mttun@ucsd.edu

I am currently an undergraduate at UCSD majoring in Biochemistry and Cell Biology. I joined the Bottini Lab in June 2019 to gain experience working in a research lab as a scientist, and plan to join the Contiguous BS/MS Program. I work under Dr. Santelli's supervision, and my research project focuses on the regulation of PTPN2 in immune cells.

Irene Choi
Irene Choi, Undergraduate Research Assistant
ivchoi@ucsd.edu

I am an undergraduate student majoring in Molecular Biology. I joined the Bottini Lab in September 2019 and am studying the post-translational regulation of the PTPN22 protein under Dr. Yang. In the future, I hope to earn my Master's degree in Molecular Biology then pursue a career in the biotech industry.

                                      Favorite Artwork: Canyon Mountains by Wayne Thiebaud
Jalin Silas Xu
Jalin Silas Xu, Undergraduate Research Assistant 
jix007@ucsd.edu

I am an undergraduate student majoring in Molecular and Cell Biology. I joined the Bottini Lab in July 2020, and I'm studying the allosteric regulation mechanism of RPTPα phosphatase activity and similar mechanisms in other RPTPs under Dr. Santelli's supervision. I hope to gain research experience, transition into the BS/MS program, and then pursue a Ph.D. degree in the future.
Sophie Hao
Sophie Hao, Undergraduate Research Assistant
yfhao@ucsd.edu

I am an undergraduate student double majoring in Molecular and Cell Biology and Human Developmental Sciences. I joined the Bottini Lab in November 2020 studying the role of PRL1 and of its interaction with SRC in the pathogenesis of systemic sclerosis under Dr. Santelli's supervision. I hope to earn my Master's degree through the contiguous BS/MS program and continue doing research afterward.
 
                                      Favorite Artwork: Chopin's Ballade No. 1 in G minor, Op. 23
Rowena Zhuang
Rowena Zhuang, Undergraduate Research Assistant 
czhuang@ucsd.edu

I am an undergraduate student majoring in Molecular and Cellular Biology. I joined the Bottini Lab in January 2021 and am currently studying the post-translational modifications of protein tyrosine phosphatase non-receptor type 22 (PTPN22/LYP) under Dr. Santelli and Dr. Yang's supervision. In the future, I hope to pursue a Ph.D. degree.
Sharon Zhao
Sharon Zhao, Undergraduate Research Assistant
ziz013@ucsd.edu

I am an undergraduate student at UCSD majoring in Molecular and Cell Biology. I joined the Bottini lab in March 2021 and am currently working under Dr. Stanford's supervision. My research is about studying the role of phosphorylation on the regulation of LMPTP and small-molecule inhibitors targeting LMPTP. I hope to continue as a BS/MS student in the future and then pursue a Ph.D. degree afterwards.

                                      Favorite movie: Toy Story series
Allison Vela
Allison Vela, Undergraduate Research Assistant
ajvela@ucsd.edu

I am an undergraduate student majoring in Microbiology. I joied the Bottini lab in Marchi 2021 and work under the supervision of Dr. Bottini. My project is focused on the regulation of PTPRA and its role in rheumatoid synoviocytes. In the future, I hope to join the BS/MS program and then pursue a Ph.D. in cancer research.