Ke Wang, Ph.D., Postdoctoral Scholar
I obtained my Ph.D. in Immunology from Peking University in July 2018 with a thesis focused on molecular mechanisms of T lymphocytes development and differentiation. I became a postdoctoral scholar at UCSD in September 2018 and joined the Bottini laboratory in June 2020. My current research focuses on the role of protein tyrosine phosphatases (PTPs) in autoimmune diseases. My goal is to become an independent investigator in immunology focusing on the understanding of the adaptive immune response in autoimmune diseases.
Ph.D., Postdoctoral Scholar
I earned my Ph.D. in Biomedical Science from CHA University, South Korea in February 2021. I joined Dr. Bottini's lab as a postdoctoral researcher that following June. During the course of my M.S. and Ph.D. degrees, my research focused on the molecular mechanisms of protein tyrosine phosphatase type IVA 1 (PTP4A1; PRL-1) in mesenchymal stem cells in chronic liver and autoimmune diseases. Now, my research investigates the molecuar mechanisms of receptor PTP sigma (PTPRS) in rheumatoid synoviocytes. I hope to become a university professor focused on mechanisms of disease and translational research in chronic diseases.
Yang Dai, Ph.D., Visiting Scholar
I received my Ph.D. degree in 2002 from the Memorial University of Newfoundland in Canada and completed my postdoctoral training in T cell biology and Immune Regulation at the La Jolla Institute for Immunology and the Torrey Pines Institute for Molecular Studies in San Diego, California. I am currently appointed as an Associate Professor at the Biomedical Research Institute of Southern California, San Diego. My research focuses on T-cell-mediated autoimmune disease, particularly Type 1 diabetes (T1D). My lab has identified one special type of secreted microvesicles or exosomes that contain endogenous retrovirus (ERV) antigens as a novel autoimmune trigger.
Madoka Fujisawa, M.D., Ph.D.,Visiting Scholar
I obtained my M.D. in 2010 from the University of Tokyo in Japan where I also completed my residency and Nephrology fellowship. I received my Ph.D. in the Division of Nephrology and Endocrinology from the University of Tokyo in 2018, focusing on atypical HUS (hemolytic uremic syndrome). I joined the Bottini lab in November 2020 as a Visiting Scholar, working on the study of signal transduction pathways relevant to autoimmune diseases. I hope to gain research experience and become an independent researcher.
Personal Motto: "Eat well, sleep well."
Brianna Hurysz, Graduate Student
I am currently pursuing my Ph.D. in Biomedical Sciences at UCSD and am co-advised by Drs. Nunzio Bottini and Stephanie Stanford. I obtained a B.S. in Biochemistry at Hobart and William Smith Colleges in 2020. I joined the Bottini & Stanford lab in the summer of 2021, and my project involves studying the potential of drugging PTPRS as a therapeutic for various pathologies including rheumatoid arthritis, multiple sclerosis, and spinal cord injury.
Martina Zoccheddu, M.S., Staff Research Associate
I obtained my M.S. degree cum laude in Medical Biotechnology in 2015 at the University of Sassari, Italy. I joined the Bottini laboratory in May 2017. My research is focused on the role of PTPRS in rheumatoid arthritis. My goal is to pursue a Ph.D. in Immunology or Biochemistry focusing my studies on chronic systemic autoimmune diseases.
Anna Belongia, Staff Research Associate
I graduated from the University of Vermont with a degree in Biochemistry in May 2020, where my work focused on investigating the alterations of the STK11 gene, which is associated with non-small cell lung carcinoma. I joined the Bottini laboratory that following September. I manage the laser capture core and perform laser-capture genomic studies on various autoimmune disease specimens under the supervision of Dr. Stephanie Stanford. My goal is to gain diverse experience as I prepare to pursue a Ph.D.
O Brother, Where Art Thou
Colton Sanders, Staff Research Associate
I obtained my Bachelor’s degrees in Biology and Chemistry from the University of North Carolina at Chapel Hill in 2020. I joined the Bottini/Stanford lab in August 2020 following my graduation. Under the direction of Dr. Stephanie Stanford, I am working to study the role of LMPTP in the development of cardiac fibrosis. My goal is to continue gaining practical research experience prior to pursuing a Ph.D.
The Devil Wears Prada
Zachary Holmes, Staff Research Associate
I received my Bachelor's degree in Molecular Biology from UCSD and finished my M.S. in Biology doing research with Dr. Stanford on LMPTP-related drug discovery and adipocyte biology. After receiving my M.S. I began working with Dr. Bottini to continue my research on PTPs as an SRA. My goal is to continue gaining research experience before pursuing a Ph.D.
Personal Motto: "Remember to be kind to yourself, just as you would be to someone you love."
Tiffany Nguyen, UCSD BS/MS Student
I received my Bachelor's degree in Biochemistry and Cell Biology from UCSD in June 2020 and am currently an M.S. student in the Bottini Lab. I joined the lab in July 2019. Currently, I am exploring the role of LMPTP in prostate cancer and cardiac fibrosis under Dr. Stanford’s guidance and supervision. I hope to become a physician-scientist in the future.
May Tun, UCSD BS/MS Student
I am currently an undergraduate at UCSD majoring in Biochemistry and Cell Biology. I joined the Bottini Lab in June 2019 to gain experience working in a research lab as a scientist, and plan to join the Contiguous BS/MS Program. I work under Dr. Santelli's supervision, and my research project focuses on the regulation of PTPN2 in immune cells.
Irene Choi, Undergraduate Research Assistant
I am an undergraduate student majoring in Molecular Biology. I joined the Bottini Lab in September 2019 and am studying the post-translational regulation of the PTPN22 protein under Dr. Yang. In the future, I hope to earn my Master's degree in Molecular Biology then pursue a career in the biotech industry.
Canyon Mountains by Wayne Thiebaud
Jalin Silas Xu, Undergraduate Research Assistant
I am an undergraduate student majoring in Molecular and Cell Biology. I joined the Bottini Lab in July 2020, and I'm studying the allosteric regulation mechanism of RPTPα phosphatase activity and similar mechanisms in other RPTPs under Dr. Santelli's supervision. I hope to gain research experience, transition into the BS/MS program, and then pursue a Ph.D. degree in the future.
Sophie Hao, Undergraduate Research Assistant
I am an undergraduate student double majoring in Molecular and Cell Biology and Human Developmental Sciences. I joined the Bottini Lab in November 2020 studying the role of PRL1 and of its interaction with SRC in the pathogenesis of systemic sclerosis under Dr. Santelli's supervision. I hope to earn my Master's degree through the contiguous BS/MS program and continue doing research afterward.
Chopin's Ballade No. 1 in G minor, Op. 23
Rowena Zhuang, Undergraduate Research Assistant
I am an undergraduate student majoring in Molecular and Cellular Biology. I joined the Bottini Lab in January 2021 and am currently studying the post-translational modifications of protein tyrosine phosphatase non-receptor type 22 (PTPN22/LYP) under Dr. Santelli and Dr. Yang's supervision. In the future, I hope to pursue a Ph.D. degree.
Sharon Zhao, Undergraduate Research Assistant
I am an undergraduate student at UCSD majoring in Molecular and Cell Biology. I joined the Bottini lab in March 2021 and am currently working under Dr. Stanford's supervision. My research is about studying the role of phosphorylation on the regulation of LMPTP and small-molecule inhibitors targeting LMPTP. I hope to continue as a BS/MS student in the future and then pursue a Ph.D. degree afterwards.
Toy Story series
Allison Vela, Undergraduate Research Assistant
I am an undergraduate student majoring in Microbiology. I joied the Bottini lab in Marchi 2021 and work under the supervision of Dr. Bottini. My project is focused on the regulation of PTPRA and its role in rheumatoid synoviocytes. In the future, I hope to join the BS/MS program and then pursue a Ph.D. in cancer research.