Fabio Forti, Ph.D. Visiting Professor
I received my BS in Chemistry (1992), MS in Analytical Chemistry (1995), and PhD in Biochemistry (2001) from the Institute of Chemistry-University of Sao Paulo, Brazil. Then I underwent postdoctoral training at the Salk Institute, the University of Sao Paulo, the Sanford Burnham Prebys Institute and the Chemistry and Biochemistry Department of UC San Diego. In 2009 I was appointed as Assistant Professor of Biochemistry and Molecular Biology at the Department of Biochemistry, Institute of Chemistry, University of Sao Paulo-Brazil and promoted to Associate Professor in 2016 (see
http://www3.iq.usp.br/pessoas_view.php?idDocente=32&idioma=us). My research interests include signal transduction by Dual Tyrosine Phosphatases and Small Rho GTPases in the control of genomic stability and DNA repair of cells under conditions of genotoxic/oxidative stress. I joined the Bottini lab in Feb 2020 as a Visiting Professor to collaborate on studies on the regulation of PTPN2 and how this phosphatase regulates signaling pathways in immune cells.
See full list of Dr. Forti’s publications on PubMed.
Angel Bottini, Ph.D., Assistant Project Scientist
I obtained my B.S degree in 2007 from UCLA majoring in Microbiology, Immunology and Molecular Genetics. Then I did my Ph.D training in Drug Discovery in the Pellecchia laboratory at the Sanford Burnham Prebys Medical Discovery Institute from 2009 to 2014 (The Pellecchia laboratory has moved to UC Riverside). I re-joined the Bottini laboratory in 2018 after my postdoctoral work focusing on non-receptor protein tyrosine phosphatase 14 (PTPN14) and its role in rheumatoid arthritis. My current research focuses on a subgroup of PTPs called phosphatase of regenerating liver (PRLs) and receptor PTP sigma (PTPRS).
Pride and Prejudice
Eugenio Santelli, Ph.D., Assistant Project Scientist
I obtained a M.S. degree in Industrial Chemistry from the University of Milan in 1993 and a Ph.D. in Structural Biology from the ETH Zurich in 2000. Subsequently, I moved to the Sanford Burnham Prebys Medical Discovery Institute as a postdoc and then as a Staff Scientist before joining the Bottini Lab in 2015. I am currently focusing on the biophysical and biochemical side of several multidisciplinary efforts aimed at understanding and modulating the function of protein tyrosine phosphatases in the immune system and in fibroblast-like synoviocytes. I also plan to develop my career towards the applied biological sciences.
See full list of Dr. Santelli's publications on PubMed.
Shen Yang, Ph.D., Assistant Project Scientist
I obtained my Ph.D. degree from the Chinese Academy of Agricultural Sciences (CAAS) in 2014, and worked as a research associate in the Shanghai Veterinary Research Institute. I joined the Bottini laboratory as a post-doctoral fellow in December 2016 and was promoted to Assistant Project Scientist in 2020. My projects are focused on the post-translational modifications of protein tyrosine phosphatases (PTPs). My goal is to become an independent investigator and focus on fundamental research with the goal to improve understanding and treatment of autoimmune diseases.
Personal Motto: "Seek victory while keeping performance stable."
Myungja Ro, Ph.D., Postdoctoral Scholar
I obtained my Ph.D. degree in biotechnology from Korea University in 2018. My Ph.D. thesis was focused on the role of the Leukotriene B4 receptor 2 in the development of asthma. I joined the Bottini laboratory as a postdoctoral researcher in August 2019. My research focuses on the role of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in rheumatoid arthritis. My goal is to become an independent researcher heading a laboratory focused on mechanisms of immune-mediated diseases and contribute to the discovery of new treatments for these diseases.
Ke Wang, Ph.D., Postdoctoral Scholar
I obtained my Ph.D. in Immunology from Peking University in July 2018 with a thesis focused on molecular mechanisms of T lymphocytes development and differentiation. I became a postdoctoral scholar at UCSD in September 2018 and joined the Bottini laboratory in June 2020. My current research focuses on the role of protein tyrosine phosphatases (PTPs) in autoimmune diseases. My goal is to become an independent investigator in immunology focusing on the understanding of the adaptive immune response in autoimmune diseases.
Denise Beckmann, Ph.D., Postdoctoral Fellow
I obtained my PhD from the University Hospital Muenster in 2019 in the Pap laboratory at the Institute of Musculoskeletal Medicine, which focuses on expression and regulation of several molecules that are associated with the aggressive-invasive behavior of rheumatoid fibroblast-like synoviocytes (FLS). For my Thesis, I investigated the function of FLS intercellular communication mechanisms, with a particular focus on cadherin-11-dependent cell-to-cell contacts and their role in rheumatoid arthritis pathogenesis. I joined the Bottini laboratory in November 2019. My research focuses on the role of protein tyrosine phosphatases (PTPs) in rheumatoid arthritis. My goal is to become an independent researcher in the field of inflammatory diseases.
Sho Sendo, M.D., Ph.D., Visiting Scholar
I obtained my M.D. degree in 2006 from the University of Toyama in Japan followed by a residency and fellowship in rheumatology. In 2017, I obtained my Ph.D. from Dr. Akio Morinobu’s laboratory at the Kobe University
Graduate School of Medicine, focusing on the role of regulatory myeloid cells in rheumatoid arthritis (RA)-associated interstitial lung disease. I joined the Bottini laboratory in August 2019. My research focuses on the role of protein tyrosine phosphatases (PTPs) in RA synoviocytes. My goal is to become an independent researcher focused on translational rheumatological research.
Personal Motto: "Progress not perfection."
Yang Dai, Ph.D., Visiting Scholar
I received my Ph.D. degree in 2002 from the Memorial University of Newfoundland in Canada and completed my postdoctoral training in T cell biology and Immune Regulation at the La Jolla Institute for Immunology and the Torrey Pines Institute for Molecular Studies in San Diego, California. I am currently appointed as an Associate Professor at the Biomedical Research Institute of Southern California, San Diego. My research focuses on T-cell-mediated autoimmune disease, particularly Type 1 diabetes (T1D). My lab has identified one special type of secreted microvesicles or exosomes that contain endogenous retrovirus (ERV) antigens as a novel autoimmune trigger.
Madoka Fujisawa, M.D., Ph.D.,Visiting Scholar
I obtained my M.D. in 2010 from the University of Tokyo in Japan where I also completed my residency and Nephrology fellowship. I received my Ph.D. in the Division of Nephrology and Endocrinology from the University of Tokyo in 2018, focusing on atypical HUS (hemolytic uremic syndrome). I joined the Bottini lab in November 2020 as a Visiting Scholar, working on the study of signal transduction pathways relevant to autoimmune diseases. I hope to gain research experience and become an independent researcher.
Personal Motto: "Eat well, sleep well."
Martina Zoccheddu, M.S., Staff Research Associate
I obtained my M.S. degree cum laude in Medical Biotechnology in 2015 at the University of Sassari, Italy. I joined the Bottini laboratory in May 2017. My research is focused on the role of PTPRS in rheumatoid arthritis. My goal is to pursue a Ph.D. in Immunology or Biochemistry focusing my studies on chronic systemic autoimmune diseases.
Megan Lee, Staff Research Associate
In May of 2019, I graduated from the University of San Diego with a Bachelor’s in Biophysics. I joined the Bottini lab that following August. My research is focused on understanding the role of tyrosine phosphatases in rheumatoid arthritis and studying their potential for therapeutic targeting. In the future, I hope to obtain an MD degree.
Anna Belongia, Staff Research Associate
I graduated from the University of Vermont with a degree in Biochemistry in May 2020, where my work focused on investigating the alterations of the STK11 gene, which is associated with non-small cell lung carcinoma. I joined the Bottini laboratory that following September. I manage the laser capture core and perform laser-capture genomic studies on various autoimmune disease specimens under the supervision of Dr. Stephanie Stanford. My goal is to gain diverse experience as I prepare to pursue a Ph.D.
O Brother, Where Art Thou
Colton Sanders, Staff Research Associate
I obtained my Bachelor’s degrees in Biology and Chemistry from the University of North Carolina at Chapel Hill in 2020. I joined the Bottini/Stanford lab in August 2020 following my graduation. Under the direction of Dr. Stephanie Stanford, I am working to study the role of LMPTP in the development of cardiac fibrosis. My goal is to continue gaining practical research experience prior to pursuing a Ph.D.
The Devil Wears Prada
Ruiyuan Zhang, Staff Research Associate
I joined the Bottini lab in January of 2018 as a BS/MS student and graduated in August of 2020. Afterward, I was recruited to the lab as an SRA1 to work on project focused on the role of PTPs in fibrosis and scleroderma. For my future, I would like to obtain a PhD in translational medicine and pursue a scientific career in the pharmaceutical/biotech industry.
Zachary Holmes, UCSD BS/MS Student
I finished my undergraduate at UCSD in 2020 with a degree in Molecular Biology. I joined the Bottini Lab in 2019, and I am currently an MS student under the supervision of Dr. Stanford. I am researching small-molecule inhibitors of LMPTP, and the role of LMPTP in obesity-induced adipogenesis and adipocyte hypertrophy. Once I finish my Master's degree, I hope to begin a career in medical research, hopefully pursuing a similar path to what I've been working on since I've joined the Bottini Lab.
Personal Motto: "Remember to be kind to yourself, just as you would be to someone you love."
Tiffany Nguyen, UCSD BS/MS Student
I received my Bachelor's degree in Biochemistry and Cell Biology from UCSD in June 2020 and am currently an M.S. student in the Bottini Lab. I joined the lab in July 2019. Currently, I am exploring the role of LMPTP in prostate cancer and cardiac fibrosis under Dr. Stanford’s guidance and supervision. I hope to become a physician-scientist in the future.
May Tun, Undergraduate Research Assistant
I am currently an undergraduate at UCSD majoring in Biochemistry and Cell Biology. I joined the Bottini Lab in June 2019 to gain experience working in a research lab as a scientist, and plan to join the Contiguous BS/MS Program. I work under Dr. Santelli's supervision, and my research project focuses on the regulation of PTPN2 in immune cells.
Irene Choi, Undergraduate Research Assistant
I am an undergraduate student majoring in Molecular Biology. I joined the Bottini Lab in September 2019 and am studying the post-translational regulation of the PTPN22 protein under Dr. Yang. In the future, I hope to earn my Master's degree in Molecular Biology then pursue a career in the biotech industry.
Canyon Mountains by Wayne Thiebaud
Longyue Wang, Undergraduate Research Assistant
I am currently an undergraduate student at UCSD majoring in Molecular and Cell biology and Clinical Psychology. I joined the Bottini laboratory in June 2020 and work on the regulation and function of PTPRS under Dr. Santelli's supervision. I hope to continue as a BS/MS student after graduation and wish to pursue a Ph.D. degree in biological science after that.
Favorite Artwork: Claude Monet's Woman with a Parasol - Madame Monet and Her Son.
Jalin Silas Xu, Undergraduate Research Assistant
I am an undergraduate student majoring in Molecular and Cell Biology. I joined the Bottini Lab in July 2020, and I'm studying the allosteric regulation mechanism of RPTPα phosphatase activity and similar mechanisms in other RPTPs under Dr. Santelli's supervision. I hope to gain research experience, transition into the BS/MS program, and then pursue a Ph.D. degree in the future.