Dr. Nunzio Bottini

Nunzio Bottini, M.D., Ph.D, is a Professor of Medicine and currently serves as the Rheumatology Section Head in the Division of Rheumatology, Allergy and Immunology at UC San Diego. He received his M.D. in 1996 from the University of Rome, where he also obtained his Ph.D. and completed his internship and residency. He received postdoctoral research training in signal transduction at the Sanford Burnham Medical Prebys Medical Discovery Institute in La Jolla, and completed a clinical fellowship in Rheumatology at the University of California, San Diego. Dr. Bottini held appointments as an Assistant Professor at the University of Rome and the University of Southern California, and an Associate Professor at the La Jolla Institute for Allergy and Immunology.
Dr. Bottini serves on grant review panels for the NIH, the Rheumatology Research Foundation, and the Arthritis Foundation, and also serves as a reviewer for various scientific journals. He serves as the Director of the NIAMS-supported Microenvironment in Arthritis Research Center at UC San Diego. The ACTRI flow cytometry core is managed by Dr. Bottini and his laboratory personnel.


About the Lab

The Bottini laboratory studies the mechanism of action of signaling molecules encoded by human autoimmune disease-predisposing genes and also analyses signal transduction pathways in pathological specimens from patients. The laboratory specializes in the study of a family of signaling enzymes called protein tyrosine phosphatases, which regulates phosphorylation of proteins on tyrosine residues.
The first focus of the laboratory is on two phosphatase genes (PTPN22 and PTPN2) that increase risk of autoimmune disease. Dr. Bottini was the first to report that a mutation in the PTPN22 gene increases the risk of autoimmunity in humans. Currently both PTPN22 and PTPN2 are ranked as major genes for rheumatoid arthritis, juvenile diabetes, inflammatory bowel disease, and lupus. A second focus of the laboratory is on studying biochemical signaling (focusing in particular on the role of phosphatases) in tissue resident cells in arthritis and scleroderma.

Dr. Bottini's laboratory is focused on understanding the mechanism of action and regulation of phosphatases with the goal of developing ways to treat autoimmune disease that are personalized and do not depress the ability of the immune system to fight against infections and tumors.

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