Adaptation to high altitude

Humans have lived at high altitude for thousands of years despite the unavoidable stress imposed by low oxygen (hypoxia).  Our work takes an integrative physiological genomics approach to understand adaptative and maladaptive variation in populations from the Tibetan Plateau, Andes, and Ethiopian highlands.  Our team further aims to integrate physiological, molecular, and genetic aspects of hypoxia responses in high-altitude adapted populations to better understand how natural variation within our species aids or impedes hypoxia challenges inherent to many common disease states.  

Center for Physiological Genomics of Low Oxygen (CPGLO)

The Center for Physiological Genomics of Low Oxygen (CPGLO) aims to maximize information from highly informative but currently separate social and biological (e.g., anthropological, physiological, 'omic, clinical) research to improve the quality of life in diverse human populations.  

Learn about the Center for Physiological Genomics of Low Oxygen (CPGLO).







Our Special Issue in Frontiers in Physiology

​Contact us

​Division of Physiology
Department of Medicine, School of Medicine
University of California, San Diego
9500 Gilman Drive, 0623A
La Jolla CA 92093-0623 USA
tsimonson@ucsd.edu