The overall aim of CPGLO is to maximize information from highly informative but currently separate social and biological (anthropological, physiological, -omic, clinical) research. The Center specifically focuses on important but understudied questions regarding human responses to low oxygen, including:
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how variation is distributed among different ancestral groups,
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how this variation influences or reflects system-wide differences in oxygen transport, and
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how these differences ultimately contribute to distinct responses to low oxygen (hypoxia) inherent to many common disease states.
Genomic and systems-level physiological and molecular data collected and analyzed through separate but highly integrated components of the center aim to address these concerns at basic and clinical research levels.