The Center for Physiological Genomics of Low Oxygen (CPGLO) aims to maximize information from highly informative but currently separate social and biological (e.g., anthropological, physiological, 'omic, clinical) research to improve the quality of life in diverse human populations. Many of our collaborative, integrative projects focus on understanding how natural variation contributes to adaptive and maladaptive responses to hypoxia (low oxygen).


"In the News"

A Single Gene Mutation May Have Helped Humans Become Optimal Long-Distance Runners 

In novel study, mice engineered to lack the same gene run stronger, longer and with less fatigue 
September 2018

Graduate student Jonathan Okerblom and Ellen Breen, PhD, 'evaluated the exercise capacity of mice lacking the CMAH gene, and noted an increased performance during treadmill testing and after 15 days of voluntary wheel running,' said Okerblom, the study‚Äôs first author. Breen added observations that the mice displayed greater resistance to fatigue, increased mitochondrial respiration and hind-limb muscle, with more capillaries to increase blood and oxygen supply. 


12-1 PM Thursday

October 11

Leichtag Auditorium, Genetics, Bioinformatics & Systems Biology Colloquium

"Archaic Admixture Facilitates Adaptation in Humans"

Emilia Huerta-Sanchez, PhD

Assistant Professor, Ecology and Evolutionary Biology and Center for Computational Biology, Brown University

3-4 PM Monday

November 5

Biomedical Research Facility II, Room 5A03, Physiology Seminar Series, CPGLO Invited Speaker

"Oxygen Sensor(s) in the Carotid Body"

Nanduri Prabhakar, PhD, DSc

Harold H. Hines Jr. Professor; Director, Institute for Integrative Physiology, Director, Center for Systems Biology, The University of Chicago

Visit the Division of Physiology site for the full seminar schedule.

Our Frontiers in Physiology special issue

Interested in joining more than 150 current participants of CPGLO?

Please contact us.

Center for Physiological Genomics of Low Oxygen   9500 Gilman Drive, La Jolla, CA 92093-0623A

Thank you for participating in the Third Annual CPLGO Summit Friday, April 20, 2018!

Visit our Events section to view the 2018 Sumiit schedule and continue to check the website for updates regarding Post-Summit opportunities and the 2019 Summit.