The Center for Physiological Genomics of Low Oxygen (CPGLO) aims to maximize information from highly informative but currently separate social and biological (e.g., physiological, anthropological, 'omic, clinical) research to improve the quality of life in diverse human populations. Many of our collaborative, integrative projects focus on understanding how natural variation contributes to adaptive and maladaptive responses to hypoxia (low oxygen).


"In the News"

A Single Gene Mutation May Have Helped Humans Become Optimal Long-Distance Runners 

In novel study, mice engineered to lack the same gene run stronger, longer and with less fatigue 
September 2018

Graduate student Jonathan Okerblom and Ellen Breen, PhD, 'evaluated the exercise capacity of mice lacking the CMAH gene, and noted an increased performance during treadmill testing and after 15 days of voluntary wheel running,' said Okerblom, the study‚Äôs first author. Breen added observations that the mice displayed greater resistance to fatigue, increased mitochondrial respiration and hind-limb muscle, with more capillaries to increase blood and oxygen supply. 


Upcoming Events

Fifth Annual CPGLO Summit

Friday, April 3, 2020

Martin Johnson House

Scripps Institution of Oceanography

Visit the Division of Physiology site for more information about seminars this quarter that include CPGLO-invited speakers and our Fourth Annual CPGLO Summit.

Our Frontiers in Physiology special issue

Interested in joining more than 200 CPGLO participants?

Please contact us.

Center for Physiological Genomics of Low Oxygen   9500 Gilman Drive, La Jolla, CA 92093-0623A

Visit our Events section to view the 2019 Sumiit schedule and continue to check the website for updates regarding Post-Summit opportunities in 2019.