Monday, March 22, 2021, noon to 1:00 pm PST
Online Only (Zoom Meeting)
Theresa Pizarro, PhD
Professor, Department of Pathology
Associate Professor, Department of Medicine
Case Western Reserve University
Role of gasdermins in gut health and disease
Speaker’s Research Interests: Dr. Pizarro is one of the researchers who has pioneered research in the field of cytokines, the messenger proteins that regulate the body’s immune responses, and, intestinal mucosal inflammation. Her discoveries contributed to the development of new therapies for patients suffering from Crohn's disease and ulcerative colitis, including antibodies against tumor necrosis factor (TNF), a cytokine involved in systemic inflammation.
Monday, April 26, 2021
Online Only (TBD)
Heather Francis, Ph.D., FAASLD
Professor of Medicine, VA Research Scientist
Scientific Director, Indiana Center for Liver Research
Richard L. Roudebush VA Medical Center Indiana University
Speaker’s Research Interests: Dr. Francis’s main focus and the goal of her basic science research program is to understand and identify target therapies for chronic and often fatal liver diseases, such as Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, and Cholangiocarcinoma. Her research team has dedicated the past several years developing a program to better understand the paracrine role that mast cells play in chronic liver diseases. Her laboratory specifically identified that in both rodent and human models mast cells play a critical role in not only the initial repair of the liver, but also in the progression of liver damage and disease. She has developed a novel technique to isolate mature hepatic mast cells from rats.
Wednesday, May 12, 2021, 10:00am to 11:00am PST
Online Only (TBD)
Fiona Powrie, FRS, FMedSci
Director, Kennedy Institute of Rheumatology, NDORMS
University of Oxford
Speaker’s Research Interests: Dr. Powrie’s research interests include characterization of the interaction between the intestinal microbiota and the host immune system and how this mutualistic relationship breaks down in inflammatory bowel disease. Dr. Powrie's work has identified the functional role of regulatory T cells in intestinal homeostasis and shed light on their development and mechanism of action. She has also shown that both adaptive and innate immune mechanisms contribute to intestinal inflammation and identified the IL-23 pathway as a pivotal player in the pathogenesis of chronic intestinal inflammation. Her current work seeks to translate findings from model systems into the clinic in inflammatory bowel disease patients.