The Human Translational Core facilitates bench-to-bedside translational studies by providing members of the San Diego Digestive Diseases Research Center ready access to human biospecimens of well-characterized cohorts of patients with digestive diseases. The Core provides clinical expertise and is led by highly accomplished clinical and translational researchers from the University of California, San Diego (UCSD) Division of Gastroenterology, with Dr. Rohit Loomba as Director, Dr. Brigid Boland as Co-Director, and Dr. Sheila Crowe as Co-Investigator. The biorepository uses state-of-the-art data management resources. Center members can request biospecimens from well-characterized cohorts of patients with Nonalcoholic Fatty Liver Disease (NAFLD) and Inflammatory Bowel Disease (IBD). Biospecimens from patients with other specific digestive diseases can be requested and will be reviewed by the Core. In addition, the Core offers biostatistical and pathological consultation services, as well as training opportunities. A board-certified GI pathologist, Dr. Mojgan Hosseini, assists with histological evaluation, and an accomplished biostatistician, Dr. Xin Tu, provides biostatistical expertise and power analysis. The Core also provides training opportunities for IRB protocol writing, biostatistical analysis, power calculation, tissue processing, immunohistochemistry, and histological evaluation.
This Core interacts with and complements the Preclinical Models and Microbiomics and Functional Genomics Cores by facilitating research to relate biomarkers and preclinical data from animal models to specific outcomes in patients with digestive diseases.
- Clinical consultation services
- Human biospecimens including needle biopsy liver tissue and endoscopic biopsy gastrointestinal tissues, whole blood, plasma, serum, peripheral blood mononuclear cell (PBMC), and stool
- Biostatistical and pathological consultation services
To obtain patient-derived materials or other services, please complete the service request form the following link: Human Translational Sample Request Form
Please notify the center by sending an email to: firstname.lastname@example.org