The Center supports three interrelated Biomedical Research Cores that are designed to enhance the research potential and productivity of the Center members. The Human Translational Core provides access to human specimens and leverages unique existing repositories of inflammatory bowel disease and liver diseases. Biostatistical and histopathological support is provided. The Preclinical Models Core facilitates and assists in characterizing and understanding of gastrointestinal and liver diseases using murine models. The Microbiomics and Functional Genomics Core provides cutting-edge and cost-effective access to sequencing-based technologies in microbiomics and functional genomics. Furthermore, an Administrative Core supports the Center administratively and coordinates the Pilot/Feasibility and Enrichment programs.