Human Translational Core

The Human Translational Core facilitates bench-to-bedside translational studies by providing members of the San Diego Digestive Diseases Research Center ready access to human biospecimens of well-characterized cohorts of patients with digestive diseases. The Core will provide clinical expertise and will be led by highly accomplished clinical and translational researchers from the University of California, San Diego (UCSD) Division of Gastroenterology, with Dr. Rohit Loomba as Director, Dr. William Sandborn as Co-Director, and Dr. Sheila Crowe as Co-Investigator. The biorepository uses state-of-the-art data management resources. Center members can request biospecimens from well-characterized cohorts of patients with Nonalcoholic Fatty Liver Disease (NAFLD) and Inflammatory Bowel Disease (IBD). Biospecimens from patients with other specific digestive diseases can be requested and will be reviewed by the Core.  In addition, the Core offers biostatistical and pathological consultation services, as well as training opportunities. A board-certified GI pathologist, Dr. Mark Valasek, will assist with histological evaluation, and an accomplished biostatistician, Dr. Xin Tu, will provide biostatistical expertise and power analysis. The Core will also provide training opportunities for IRB protocol writing, biostatistical analysis, power calculation, tissue processing, immunohistochemistry, and histological evaluation.

This Core will interact with and complement the Preclinical Models and Microbiomics and Functional Genomics Cores by facilitating research to relate biomarkers and preclinical data from animal models to specific outcomes in patients with digestive diseases.

Services Offered:

  • Clinical consultation services
  • Human biospecimens including needle biopsy liver tissue and endoscopic biopsy gastrointestinal tissues, whole blood, plasma, serum, peripheral blood mononuclear cell (PBMC) and stool 
  • Biostatistical and pathological consultation services

 

For obtaining patient-derived materials or other services, Center members can make an online request: sddrc@ucsd.edu