Dr. Ghosh obtained her medical degree from Christian Medical College, Vellore, in India. She started her career in science under the mentorship of Stuart Kornfeld at Washington University in St. Louis, Missouri, before beginning her internship and residency in internal medicine and a postdoctoral training in the laboratory of Marilyn G. Farquhar here at UC San Diego. Her postdoctoral work has directly led to the characterization of a novel stratum in signal transduction by a unique class of molecules, which she christened GEMs, an abbreviation for Guanine nucleotide Exchange Modulators”.
Since being appointed at UCSD, the Ghosh lab continues to investigate how G proteins and their modulators, GEMs, are regulated by receptor and non-receptor tyrosine kinases /phosphatases that are triggered by growth factors. In launching the Center for Network Medicine (CNetMed), Pradipta's goal is to not only reveal the importance of GEMs in health and diseases, but also unravel other molecules like GEMs that support a complete system of network-protocols for cellular communication; in short, she seeks to decode the Intranet of cells (IoC) using a transdisciplinary approach. The CNM also supports the complete pipeline for network-based target identification and validation through our own Precision Network Medicine initiative, which includes HUMANOID™, a human organoid-based platform. While network-based drug discovery can offer precision in targeting, HUMANOID allows personalized disease-modeling platforms for drug screening. Dr. Ghosh's overall vision is to drive disruptive research in biology, medicine and engineering using the fundamentals of the IoC paradigm, with the ultimate goal of enhancing, enriching and improving human existence.
Pradipta Ghosh's Full Bio