Active Funding:
R01 CA100768 (PI: Ghosh) 02/01/15-01/31/20
National Institute of Health (NIH)/NCI
Spatial Regulation of RGS and G Protein Signaling
Major Goals: To assess the functional interaction between Gαi3 and GIV during cell migration; to investigate the spatial and temporal regulation of Gαi3 and GIV’s interaction and trafficking during cell migration; and to pinpoint the mechanisms by which Gαs and RGS-PX1 affect EGF receptor signaling, trafficking, and sorting for degradation.
R01 CA238042-01 (PI: Ghosh, MPI: Luker) 03/01/19 - 02/28/24
National Institute of Health (NIH)/NCI
Imaging Metastatic Potential
Major Goals: This proposal seeks to develop, synthesize, select, optimize, and validate novel GIV-derived fluorescent biosensors/ probes to detect and measure the 'potential' for metastasis of single living cancer cells. Successful development of these probes is expected to allow personalized screening platforms to assess effectiveness of treatment selectively against the highly tumorigenic cells within any given tumor.
R01 AI141630 (PI: Ghosh) 06/01/19- 05/30/24
National Institute of Health (NIH)/NIAID
Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal Inflammation
Major goals: These studies are expected to yield novel ways to reprogram macrophages during inflammation via the modulation of GIV/Girdin.
UG3TR002968 (PI Ghosh, Das) 09/01/2019-08/31/23
National Institute of Health (NIH)/NCATS
Network-based therapeutics in Colorectal carcinoma.
Major Goals: Use of Boolean Networks to identify candidate targets/therapeutics for programming stemcells towards a pro-differentiation axis and testing the efficacy of compounds in CRC and adenoma-derived organoids. Co-Investigators = Sahoo, Patel, Huang, Sivagnanam, Gupta.
R01 CA160911 (PI: Ghosh) 02/01/13- 01/31/20 [NCE]
National Institute of Health (NIH)/NCI
Modulation of G proteins by Growth Factors
Major goals: These studies are expected to yield novel information and mechanistic insights into the cross-talk between G proteins and growth factors in regulating oncogenic signal transduction in breast and colorectal cancers.
Crohn’s Disease Project Grant (PI: Ghosh, Das; Co-I: Sahoo, Sandborn) 01/01/2019 – 12/31/2022
The Helmsley Charitable Trust and Foundation
Transforming Crohn’s disease Therapeutics: Where precise and predictable network-based targets are personalized through Phase ‘0’ human trials
Major Goals: 1) Develop a biobank of genotyped and phenotyped enteroids from CD patients; 2) Test the efficacy of novel and existing biotherapeutics by executing a Phase ‘0’ trial on patient derived-organoids; 3) Assess if barrier/mucosal-healing is necessary and sufficient to reset the disease network in CD and achieve deep remission. This project will produce advancements that will: 1) Precisely assess the value of any target in CD; 2) Effectively predict which drug(s) will be most effective; 3) Usher an era of Phase ‘0’ human trials that personalize each patient’s treatment.
The Concept Research Award (PI: Ghosh, Das) 07/01/18 – 06/30/20
Sanford Stem Cell Consortium
Stem-cell based approaches to develop gut barrier-protective therapies in IBD
Major goals: The proposed studies will identify new target in IBD, i.e., the leaky gut barrier, and expand our armamentarium of molecular biomarkers to enrich proof-of-concept clinical trials for early drug discovery.
Tobacco-related Disease Research Program (TrDRP) (PI: Ghosh, co-I Das) 07/01/18 – 06/30/20
Effect of e-cigarettes, tobacco and cannabinoids on the gut mucosa
Major goals: The proposed studies will expose the impact of substances of abuse on the gut barrier and systemic endotoxemia.
Chancellor’s Center Seed Launch Award- Center for Network Medicine (PI: Ghosh) 03/01/18- 08/31/19
Office of Research Affairs, UC San Diego
Formulating Laws in Medicine by Decoding the Network Architecture of the Cell
Major Goals: We at the Center for Network Medicine strive to unravel the rules of intracellular and cell-cell communication using insights from engineered networks that are used for communication.
T32DK0070202 (PI: Crowe, Ghosh) 7/1/2018 – 6/30/2023
National Institute of Health (NIH)/NIDDK
Predoctoral and Postdoctoral Training in Diseases of the Gastrointestinal System
Major Goal: To prepare trainees for careers in basic or clinically-related research in academic institutions or industry.
COMPLETED AWARDS
Career Awards for Medical Scientists (PI: Ghosh)
Burroughs Welcome Fund 09/01/09 – 08/31/14
Title: Modulation of G protein Signaling During Oncogenic and metastatic Progression
Major Goals: Unraveling the mechanism by which EGF-receptor tyrosine kinase triggers growth and invasion during tumor progression.
Clinical Scientist Development Award (PI: Ghosh)
Doris Duke Charitable Foundation (DDCF) 08/01/10 – 07/31/13
Title: A Marker and a Therapeutic Target in Liver Fibrosis
Major Goals: The goal of this study is to investigate the role of a recently discovered G protein-dependent signaling rheostat in balancing profibrotic and antifibrotic pathways during fibrogenesis; more specifically, in hepatic stellate during liver cirrhosis.
American Cancer Society IRG (PI: Ghosh)
American Cancer Society (ACS) 11/01/11-10/31/13
Title: Taming Aberrant G protein Signals during Oncogenic Progression
Major Goals: A seed grant to investigate transcriptional and posttranslational regulation of GIV in tumor cells and discover small molecules to inhibit signaling via GIV.
UC San Diego Roche Collaboration (PI: Ghosh)
Ventana Medical Innovation Inc. (Roche Diagnostics) 08/01/12 – 07/31/13
Title: Role of GIV as a biomarker for prognostication in patients with colorectal and breast cancers.
Major Goals: A seed grant to develop tools and techniques in collaboration with Roche Diagnostics for use in multi-centric international clinical trials on patients with breast and colorectal cancers. Primary goal is to evaluate the efficacy and accuracy of prognostication when using GIV-based markers as opposed to other currently used indicators in these tumors.
DOD Visionary Fellowship Award (Fellow: Laederich)
Department of Defense (DOD) 01/01/13 – 12/31/16
Title: Modulating Multi-receptor Network in Invasive Colorectal Cancers via a Single Interface.
Major Goals: Here, we propose to discover, characterize, and target a novel interface in multi-receptor signaling using HTP approaches and monitor the effect of modulating the interface with small molecules using whole genome shotgun approach. Insights gained will help develop this interface as a powerful therapeutic target in invasive colorectal cancers.
Clinical Research Mentorship Award (Fellow: Gary Ma)
Doris Duke Charitable Foundation 06/01/13 – 05/31/14
Title: Molecular Rheostats in Type II Diabetes: Novel Therapeutic Targets in Insulin Resistance
Major Goals: The overall goal of the proposed research is to unravel the mechanisms by which GIV maintains insulin sensitivity and how its phosphoinhibition generates Insulin resistance (IR). Insights gained will not only help determine whether GIV can serve as a therapeutic target and a marker for prognosticating response to therapy in patients with IR, but also help decipher, access, and manipulate the entire signaling network to restore physiologic insulin response.
Research Scholar Award (PI: Ghosh)
American Gastroenterology Association 01/07/08 – 01/07/11
Title: Modulation of G protein signaling during colon cancer progression
Academic Senate Research Grant (PI: Ghosh)
University of California 02/01/11 – 01/31/12
Title: A Critical Hub Used by Multiple Receptors to Activate PI3K Signals during Tumor Invasion
Translational and Clinical Cancer Research Award (PI: Ghosh) 5/1/2015 – 4/29/2016
Rebecca and John Moores Cancer Center (UCSD)
Title: Imaging the metastatic potential of lung cancers
Major Goals: Pilot study to investigate the effectiveness of a novel GIV-derived biosensor in its effectiveness to visualize metastatic potential of cancer cells at a single-cell resolution.
Translational and Clinical Cancer Research Award (PI: Ghosh; Co-I: Ho) 5/1/2016 – 4/29/2017
Rebecca and John Moores Cancer Center (UCSD)
Title: Therapeutic and Prognostic Potential of a Novel Signaling Pathway in Colorectal Cancer
Major Goals: Pilot study to investigate the role of Daple at the converge point between Wnt, growth factors and G protein pathways in physiology and colorectal cancer.
1R43AA025498-01 (PI: Hayes; Paid consultant: Ghosh) 09/20/16 – 08/31/17
Title: Pharmacological Validation of GIV/Girdin, a Guanine Nucleotide Exchange Factor, for Liver Fibrosis
Major Goals: The broad goal of this project is the pharmacological validation of GIV, a non-receptor guanine nucleotide exchange factor (GEF), for liver fibrosis. It is based on groundbreaking work by us showing that GIV is an atypical GEF that sits at the hub of profibrogenic signaling in liver fibrosis.