Status: Currently recruiting subjects
Required visits: Single visit
Age of participants: Greater than 18 years
Gender of participants: Male and Female
PI: Rohit Loomba, MD
This is a cross-sectional study consisting of a one-time visit by first degree relatives of patients with cirrhosis. The aim of the study is to evaluate genetic covariance between magnetic resonance imaging determined liver fat fraction, liver stiffness, and traits of the metabolic syndrome.
During the visit, the patient with cirrhosis and their first-degree relatives will undergo review of medical history, vitals (including body mass index, blood pressure), physical exam, blood work, magnetic resonance imaging (MRI) including elastography, and ultrasound using acoustic radiation force impulse (ARFI) imaging. Blood work will be sent for labs relevant for traits of the metabolic syndrome including markers for diabetes (hemoglobin A1C, fasting glucose) and hyperlipidemia (lipid panel). Serum, plasma, urine, stool, whole blood and whole blood peripheral blood mononuclear cells (PBMCs) will also be stored for future studies. Interested participants will be invited for annual follow up visits for two years.
Results from history, physical exam, and radiographic imaging will be used together with previously available genetic data to study genetic covariance of nonalcoholic fatty liver disease (NAFLD) and traits of the metabolic syndrome.
For additional questions regarding this study, please contact:
Shirin Bassirian, MD
Clinical Research Coordinator