2017 - Present
Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.
RalA controls glucose homeostasis by regulating glucose uptake in brown fat.
ERRγ Preserves Brown Fat Innate Thermogenic Activity.
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue.
Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation.
Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation.
Creatine Fuels the Thermic Effect of Feeding.
Adapting to obesity with adipose tissue inflammation.
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.
Inflammatory mechanisms linking obesity and metabolic disease.
View all publications on PubMed
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