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Insulin resistance causes the epidemic diseases of our era...

but it is invisible even to trained clinical eyes.

Translational investigation of insulin resistance and cardio-metabolic diseases

See our recent publications

Get to know our lab members
Join our team

The Majithia lab is recruiting talented and enthusiastic scientists at all levels to join our group!

Our Mission: Develop new ways to detect and treat insulin resistance 

We study human insulin resistance using the tools of human genetics and functional genomics. Our goal is to diagnose patients and identify therapeutic targets for cardiometabolic diseases-- diabetes, heart attacks, strokes and fatty liver

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Our Approach:

Genotype-Function-Phenotype

We apply a multi-disciplinary approach to investigation—
grounded in human genetics, clarified through systematic, high throughput cellular experimentation, and calibrated by its relevance to disease. 
1. Genotype: human genetic/genomic variation; genome engineering 
2. Function: massively parallel, disease-calibrated cellular assays; serum/tissue biomarkers 
3. Phenotype: clinical trial outcomes and real-world patient health data


Our Research Programs


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Therapeutic Target Identification

Therapeutic Target Identification

Identify genes that protect from insulin resistance
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Individually tailored therapy

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Next-generation phenotyping



Lab News and Announcements 

September 2022: Welcome Postdoctoral Fellows Rizaldy Zapata and Nahuel Garcia, Masters student Zhiyi Zhu, and Biomedical Sciences PhD student Rachel Diao to the lab!

August 2022: Natalie DeForest and Xiaomi Du present their research at the NASH Keystone Conference in Whistler, BC, Canada (photos).

July 2022: Our work on accuracy of continuous glucose monitors has been published, check it out here.

  • Boeder et. al. "Accuracy and Glycemic Efficacy of Continuous Glucose Monitors in Critically Ill COVID-19 Patients: a Retrospective Study". JDST 2022

March 2022: Our work on identification and characterization of gain-of-function HNF1A genetic variants is in pre-print, check it out here.

  • "Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of multiple cardiovascular disease risk factors". medRxiv 2022

March 2022: Our review on the genetics of Type 2 Diabetes has been published, check it out here.

  • DeForest, N., Majithia, A.R. Genetics of Type 2 Diabetes: Implications from Large-Scale Studies. Curr Diab Rep 22, 227–235 (2022).

March 2022: Welcome Bioinformatics & Systems Biology PhD student Emily Kobayashi to the lab!

February 2022: Our work with real-time continuous glucose monitoring has been published, check it out here.

  • "Medication Optimization Among People With Type 2 Diabetes Participating in a CGM-Driven Virtual Care Program: Prospective Trial.", JMIR Formative Research 2022
December 2021: Our review on the genetics of non-alcholic fatty liver disease (NAFLD) has been published, check it out here.

  • "Human Genetics to Identify Therapeutic Targets for NAFLD: Challenges and Opportunities", Frontiers in Endocrinology 2021