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Insulin resistance causes the epidemic diseases of our era...

but it is invisible even to trained clinical eyes.

Translational investigation of insulin resistance and cardio-metabolic diseases

See our recent publications

Get to know our lab members
Join our team

The Majithia lab is recruiting talented and enthusiastic scientists at all levels to join our group!

Our Mission: Develop new ways to detect and treat insulin resistance 

We study human insulin resistance using the tools of human genetics and functional genomics. Our goal is to diagnose patients and identify therapeutic targets for cardiometabolic diseases-- diabetes, heart attacks, strokes and fatty liver

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Our Approach:

Genotype-Function-Phenotype

We apply a multi-disciplinary approach to investigation—
grounded in human genetics, clarified through systematic, high throughput cellular experimentation, and calibrated by its relevance to disease. 
1. Genotype: human genetic/genomic variation; genome engineering 
2. Function: massively parallel, disease-calibrated cellular assays; serum/tissue biomarkers 
3. Phenotype: clinical trial outcomes and real-world patient health data


Our Research Programs


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Therapeutic Target Identification

Therapeutic Target Identification

Identify genes that protect from insulin resistance
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Individually tailored therapy

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Next-generation phenotyping



Lab News and Announcements 

August 28, 2020: Our study using continuous glucose monitoring devices has been published, check it out here.

  • "Glycemic Outcomes in Adults With Type 2 Diabetes Participating in a Continuous Glucose Monitor–Driven Virtual Diabetes Clinic", J Med Internet Res 2020  

March 31, 2020: Our recent findings in the UK Biobank have been published, check it out here.

    • "Thousands of missing variants in the UK Biobank are recoverable by genome realignment", Annals of Human Genetics, 2020