“How an old asthma drug could be a new diabetes treatment,” UC San Diego Health, features
Dr. Alan R. Saltiel, August 15, 2017.
7th ANNUAL GNF – JDRF DIABETES RESEARCH SYMPOSIUM
New Frontier in Beta Cell Biology: Molecular Targeting to the Beta Cell
Thursday, April 27, 2017
8:30 a.m. – 4:00 p.m.
GNF
10675 John Jay Hopkins Dr.
San Diego, California 92121
Featured Speakers:
Reza Abdi, Harvard Medical School
Benjamin Cravatt, The Scripps Research Institute
Neal Devaraj, University of California, San Diego
Carmella Evans-Molina, Indiana University
Bryan Laffitte, Genomics Institute of the Novartis Research Foundation
Philip Low, Purdue University
Francesca Mulas, University of California, San Diego
Chun Zeng, University of California, San Diego
Liangfang Zhang, University of California, San Diego
Register before April 20, 2017 by visiting
www.regonline.com/GNFJDRF
Summaries for Previous Meetings
May 17-18, 2016
8:00 am – 8:00 pm
LIPID MAPS Annual Meeting 2016: Lipidomics Impact on Metabolic, Cancer, Cardiovascular and Inflammatory Diseases
UNIVERSITY OF CALIFORNIA, SAN DIEGO
Scripps Seaside Forum
Host: Edward A. Dennis, Ph.D.
Contact: Odalis Felix dennisoffice@ucsd.edu
For more info: http://www.lipidmaps.org/meetings/2016annual/index.html
ANNUAL DRC RETREAt and Workshop, April 12, 2016
The 9th San Diego Beta Cell Society Meeting was held on Wednesday, November 4, 2015 at the UCSD Faculty Club. Keynote speaker, Dr. Marc Prentki from the Montreal Diabetes Research Center, presenedt on metabolic signaling in the pancreatic beta cell. The event will started at 4:00PM and featured talks from local young investigators.
Organized by Daniel Porte Jr., MD and Maike Sander, MD
LIPID MAPS Annual Meeting 2015
Lipidomics Impact on Cancer, Metabolic and Inflammatory Diseases
Meeting Dates
Tuesday, May 12, 2015
Wednesday, May 13, 2015
Early Registration Ends:
April 3, 2015
Poster Abstract Deadline
April 3, 2015
Location - La Jolla, CA
Scripps Seaside Forum, UCSD
Meeting Overview
This is an exciting time for the emerging field of lipidomics. With the development and evolution of sophisticated mass spectrometers linked to highly efficient liquid chromatography systems, individual molecular species of lipids can now be isolated identified, and quantified, allowing us to begin to understand lipid metabolism and the treatment of lipid-based diseases (atherosclerosis, arthritis, cancer, diabetes, Alzheimer's disease, and other inflammatory diseases). Recent awareness that each category of lipid consists of thousands if not tens of thousands of individual molecular species requires sophisticated informatics to ensure consistent databasing and annotation of the numerous lipid molecular species and analysis of tremendous quantities of experimental data.
The goal of this meeting is to bring together biological and biomedical scientists in a wide range of fields to share new findings and methods in the broader lipidomics field and to explore joint efforts to extend the use of these powerful new methods to new applications. Presentations will provide an excellent introduction for scientists new to these methods, and are sure to be of interest to lipidomics veterans who want to learn the latest techniques and research results.
Program
This year's meeting program featured lipidomics impact on cancer, metabolic and inflammatory diseases.
Confirmed Speakers
• Alan Aderem (Seattle Biomedical Research Institute)
• Hiroyuki Arai (University of Tokyo, Japan)
• Nicolas G. Bazan (Louisiana State University)
• Steven Bensinger (University of California, Los Angeles)
• Ian A. Blair (University of Pennsylvania)
• George M. Carman (Rutgers University)
• Jason G. Cyster (University of California, San Francisco)
• Shelah Ferguson-Miller (Michigan State University)
• Tony Futerman (Weizmann Institute, Israel)
• Christian Metallo (University of California, San Diego)
• Marcia E. Newcomer (Louisiana State University)
• Daniel K. Nomura (University of California, Berkeley)
• Valerie O’Donnell (Cardiff University, UK)
• Hugh Rosen (The Scripps Research Institute)
• Marion B. Sewer (University of California, San Diego)
• Michael Snyder (Stanford University)
• Robert M. Stroud (University of California, San Francisco)
• Jean Vance (University of Alberta, Canada)
• David Wishart (University of Alberta, Canada)
• Huiyong Yin (Shanghai Institutes for Biological Sciences, China)
Poster Sessions will take place on both days of the meeting. Several lightning talks will be selected from poster submissions.
The Networking Reception and Dinner Tuesday evening (included in the registration fee) are an opportunity for stimulating discussion and networking.
Questions?
Please contact Catherine Liu (dennisoffice@ucsd.edu, 858-534-2173) or Milda Simonaitis (msimonaitis@ucsd.edu, 858-822-5853).
The Diabetes Research Center held its research meeting and symposia at UCLA on February 11, 2015.
We hosted a Junior Faculty Development Workshop.
4th Annual Pediatric Diabetes Research Center (PDRC) Symposium
Friday, January 31, 2014 (8am - 4pm) at the Sanford Consortium for Regenerative Medicine in La Jolla.
Session topics will focus on life and death of beta-cells in diabetes with presentations from the following distinguished speakers:
· Orian Shirihai, Boston University Medical Center
· Fumihiko Urano, Washington University School of Medicine
· James D. Johnson, University of British Columbia
· Chuxia Deng, NIH/NIDDK
· Randal Kaufman, Sanford-Burnham Medical Research Institute
· Jerrold Olefsky, UC San Diego
· Ulupi Jhala, UC San Diego
· Wenxian Fu, UC San Diego
The program agenda and registration information is posted on the PDRC website at http://peds.ucsd.edu/pdrc/news-events/.
LIPID MAPS Annual Meeting 2013:
Impact of Lipidomics on Oxidized Lipids and Non-Alcoholic Fatty Liver Disease
May 7-8, 2013, La Jolla, CA
http://www.lipidmaps.org/meetings/2013annual/index.html
Meeting Overview
This is an exciting time for the emerging field of lipidomics. With the development and evolution of sophisticated mass spectrometers linked to highly efficient liquid chromatography systems, individual molecular species of lipids can now be isolated identified, and quantified, allowing us to begin to understand lipid metabolism and the treatment of lipid-based diseases (atherosclerosis, arthritis, cancer, diabetes, Alzheimer's disease, and other inflammatory diseases). Recent awareness that each category of lipid consists of thousands if not tens of thousands of individual molecular species requires sophisticated informatics to ensure consistent databasing and annotation of the numerous lipid molecular species and analysis of tremendous quantities of experimental data. The goal of this meeting is to bring together biological and biomedical scientists in a wide range of fields to share new findings and methods in the broader lipidomics field and to explore joint efforts to extend the use of these powerful new methods to new applications. Presentations will provide an excellent introduction for scientists new to these methods, and are sure to be of interest to lipidomics veterans who want to learn the latest techniques and research results.
This year's meeting program features two main thrusts: Oxidized lipid functioning & non-alcoholic fatty liver disease.
Several lightning talks will also be selected from poster submissions.
Poster sessions will take place on both days of the meeting. The poster abstract deadline is Saturday, March 09, 2013.
The reception and dinner Tuesday evening (included in the registration fee) are an opportunity for stimulating discussion and networking.
Please register as soon as possible, as space is limited and registration is on a first-come-first-served basis. The early registration deadline is Saturday, March 09, 2013.
We look forward to seeing you at this exciting meeting!
Important dates
March 09, 2013 - Early registration deadline
March 09, 2013 - Poster abstract deadline
April 05, 2013 - Hotel reservation deadline
April 23, 2013 - Registration cancellation deadline
May 7-8, 2013 - Meeting dates
May 8-9, 2013 - Committee meetings (committee members only)
2010 Diabetes Center Annual Retreat - Summary
On
December 13th 2010 the UCSD/UCLA Diabetes Center held its Annual Retreat at the Covel Commons Conference Center at UCLA. The event drew over seventy-five members from both campuses and affiliated institutions. After an introduction by Professor Jerry Olefsky, the DERC director, the keynote speaker, professor Peter Tontonoz of the HHMI at UCLA led the day with a lecture reviewing the
control of cholesterol metabolism by nuclear receptors and the role of his newly described molecule, IDOL, which has a central role in these processes. Dr. Pinchas Cohen, a UCLA professor and associate director of the DERC spoke about the pilot and feasibility awards and compared our center to practices around the country. Dr.
Dayoung Oh, the Center’s inaugural Junior Faculty Developmental Award winner, spoke about the work described in her recent Cell paper together with Dr. Olefsky, entitled: GPR120 Is an
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Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects. The event featured several talks from outstanding former pilot and feasibility grant awardees and the final lecture was by Professor Jake Lusis on
systems genetics approach to complex cardiovascular and metabolic traits. The event concluded with a wine and cheese reception coupled with viewing of twenty exceptional posters from young center investigators including recent
feasibility grant awardees.
USC
Southern California Research Center for ALPD and Cirrhosis JOINT SYMPOSIUM with the UCSD/UCLA DERC
USC
Southern California Research Center for ALPD and Cirrhosis
JOINT SYMPOSIUM with the UCSD/UCLA DERC
Keck School of Medicine of the University of Southern California
McKibben Hall (MCH), Room 149, Health Sciences Campus
1333 San Pablo Street, Los Angeles, CA 90033, Info: (323) 442‐3121 or handan@usc.edu
DECEMBER 4, 2009 at USC in Los Angeles
8:30-9:00 Continental Breakfast
9:00-9:10 Welcoming Remarks, Hide Tsukamoto, DVM, Ph.D.
Mechanisms of Liver Metabolism and Fatty Liver
9:10-9:35 Barry M. Forman, Ph.D., Professor and Director, Gene Regulation &
Drug Discovery, The Beckman Research Inst., City of Hope Med Center
“FXR and Hepatic Metabolism: on the Fast Track”
9:40-10:05 Marc Montminy, Ph.D.
Professor, Clayton Foundation, The Salk Institute
“Regulation of Hepatic Gluconeogenesis by the TORC/CRTC
Family of CREB Coactivators”
10:10-10:35
Mark Czaja, M.D.
Professor of Medicine, Albert Einstein College of Medicine
“Regulation of Cellular Lipid Accumulation by Macroautophagy”
10:40-10:55 Break
11:05-11:20 Kuk-Wha Lee, M.D., Ph.D.
Assistant Professor of Pediatrics, UCLA
“Contribution of the Growth Hormone/Insulin-Like Growth Factor Axis in the Pathophysiology of Hepatic Steatosis”
Pilot Projects
11:25-11:40 Ekihiro Seki, M.D., Ph.D., UCSD
“TLR Signaling in ASH vs. Non-ASH”
11:45-12:00 Kinji Asahina, Ph.D., USC
“Hepatic Stellate Cell Precursors in Developing and Fibrotic Livers”
12 :05-12:20 Jenny Yuan, Ph.D. UCLA/West LA VA
“The Role of Protein Kinase D in Alcoholic Pancreatitis”
12:25-12:40 Bernd Schnabl, M.D., UCSD
“Early Bacterial Translocation in Alcoholic Liver Injury”
12:45-13:35 Lunch
13:35-13:45 Special Remarks : Samir Zakhari, Ph.D. Director,
Division of Metabolism and Health Effects, NIAAA/NIH
13:45-14:30 Postdoc Presentations
Oxidant Stress, Inflammation, and Cancer
14:30-14:55 David Brenner, M.D.
Vice Chancellor for Health Sciences, Dean, UCSD School of Medicine
“ROS, NADPH oxidase, and liver fibrosis”
15:00-15:25 Neil Kaplowitz, M.D.
Professor and Director, USC Research Center of Liver Disease
“Mitochondrial and ER stress Coupling”
15:30-15:55
Hide Tsukamoto, DVM, PhD
Professor and Director, ALPD and Cirrhosis Research Center
“NASH Models”
16:00-16:20
Keigo Machida, Ph.D.
Assistant Professor, Dept of Mol. Microbiology and Immunology, USC
“Liver Cancer Stem Cells Generated by HCV, Alcohol, and Obesity”
16:25-16:40 Break
16:40-17:05 Jerome Rotter, M.D.
Professor, Pediatrics and Human Genetics, UCLA/Cedars Sinai
"Genome-Wide Association of IBD -- From Susceptibility to Therapy"
17:10-17:35 Anna Gukovskaya, Ph.D.
Professor and Senior Career Scientist, UCLA, West LA VA
“Autophagy in Pancreatitis”
17:40-18:00 Simon Beaven, M.D., Instructor, Gastroenterology, UCLA
“LXR Signaling in Hepatic Inflammation and Fibrosis”
18:05-18:15 Closing Remarks, Jerry Olefsky, M.D. |
18:30-20:30 Reception and Dinner in the
Seaver Residence Hall
MEETING REVIEWS for Recent DERC Meetings
Frontiers of Clinical Investigation Symposium
Clinical Investigation Institute/Nature Medicine
Bench to Bedside: Metabolism
October 8-10, 2009
REPORT: Clinical Investigation Institute/Nature Medicine Mtg
Bench to Bedside: Metabolism; October 8-10, 2009
On October 8-10, 2009, an outstanding meeting was hosted by Nature Medicine and UCSD focused on Metabolic Diseases. The meeting was held at the Hilton Torrey Pines in La Jolla and featured a stellar group of speakers, including: Gokhan Hotamisligil, Peter Libby, Helen Hobbs, Michael Karin, Steve Shoelson, Paresh Dandona, Gerry Shulman, Ira Goldberg, Philipp Scherer, Barbara Kahn, Christopher Newgard, Tony Lam, Zofia Zukowska, Daniel Drucker, David Cummings, and Francesco Rubino. The meeting was divided into several interrelated sessions, including: (1) Lipids and Atherosclerosis, (2) Metabolic Disease and Inflammation, (3) Muscle Function and Metabolism, (4) Mechanisms of Obesity, (5) CNS Hormone Regulation, and (6) Diabetes/Metabolic Surgery. In addition to the invited speakers, over 100 abstracts were submitted to the meeting. Several were selected for short talks given during the program and the others were exhibited as poster presentations. The meeting spanned a wide range of research in metabolic diseases, ranging from very basic investigation all the way up to clinical research, including the use of bariatric surgery to treat diabetes. This range of talks revolved around the theme of the overall program, whi.png) ch was Bench to Bedside Research in Metabolism. Wolfgang Dillmann and Jerrold Olefsky from our UCSD/UCLA DERC, as well as Gary Firestein, were the organizing Committee from UCSD, partnering with Juan Carlos Lopez and Randy Levinson from Nature Medicine.
Keynote Speaker: Michael Brown
(U Texas)
The highlight of the meeting was the opening Keynote Presentation by Dr. Michael Brown. His talk covered 30 years of research from the Brown and Goldstein lab, and was a true tour de force. The science underlying his talk was at the absolutely highest level and the presentation itself was magnificent. He discussed their Nobel prize-winning work on the discovery of the LDL receptor, its regulation by intracellular cholesterol levels and how this led to the recognition of Familial Hypercholesterolemia. Their findings were instrumental in the discovery and development of HMG-Co-A reductase inhibitors (“statins”), which are the most widely prescribed pharmaceuticals in the world. Dr. Brown then went on to describe their work on the detailed mechanisms of intracellular cholesterol regulation through the coordinated interactions between SREBP, SCAP, and INSIG1. Junior faculty and fellows attending were inspired, and many commented that this talk motivated them to fully pursue careers in biomedical science. Based on the success of this symposium, it is likely that Nature Medicine will go on to sponsor another meeting on this topic within the next two years. This meeting was immediately followed by the Western Section DERC symposium in the same hotel, which contributed to the success of our DERC meeting. |
Speakers Included:
- Michael Brown (U Texas)
- Helen Hobbs (U Texas)
- Gokhan Hotamisligil (Harvard)
- Peter Libby (Harvard)
- Michael Karin (UCSD)
- Steve Shoelson (Joslin Diabetes Center)
- Paresh Dandona (SUNY Buffalo)
- Gerry Shulman (Yale)
- Ira Goldberg (Columbia)
- Phil Scherer (U Texas)
- Barbara Kahn (Harvard)
- Chris Newgard (Duke)
- Tony Lam (Toronto)
- Zofia Zukowska (Georgetown)
- Daniel Drucker (Toronto)
- David Cummings (U Wash)
- Francesco Rubino (Cornell Medical Center-NYC)
Hilton La Jolla Torrey Pines
10950 North Torrey Pines Road, La Jolla, California
The First Western DERC Meeting
The First Western DERC Meeting
October 10th, 2009
Meeting REPORT:
The First Western DERC Meeting
Oct. 10, 2009; Keynote Speaker:Professor Ron Evans, Salk Institute |
In an effort to advance the scientific and mentoring collaborations among the four Western DERCs, initiated a new venue for early career investigators who received a P&F grant from their DERC in which members of the four Western DERCs (UCSD/UCLA, University of Washington, Baylor College of Medicine, and University of Colorado at Denver) interacted and presented data. Over seventy DERC members attended the meeting, which began with a superb presentation by Dr. Ron Evans and included 10 outstanding oral presentations (two each from the five Universities), followed by a Wine & Cheese Poster session. The general feedback from the attendees suggests that the forum was a great success and allowed enriching interactions and discussions. We expect to hold similar meetings in collaboration with these institutions in the future.
Organizer: Dr. Pinchas Cohen.
Program
1:30-1:40 Opening remarks: Jerry Olefsky, Director of the DERC
1:40-2:20
Keynote Speaker:Professor Ron Evans, The Salk Institute
2:20-3:30 Introduction to the WDERC: Hassy Cohen, DERC Co-Director
2:30-3:45
Selected talks: Insulin Action & T2DM
Michael Downes, UCSD
Promoter Ontology Analysis of Nuclear Receptors
Greg Morton, Univ. Washington
Hypothalamic Signaling and Insulin Sensitivity
Laura Cobb, UCLA
Novel Mitochondrial Peptides and their Role in Metabolism
David Maahs, Univ. Colorado, Denver
Lipoprotein Sub-fractions and Atherogenesis in Diabetes
Andrea Hevener, UCLA
ERα Effects on Inflammation and Insulin Action
3:45-4:05
Recent highlights of the UCSD/UCLA DERC Cores
Peter Tontonoz, UCLA, The Inflammation Core, Core E
Harnessing Inflammation Markers for Diabetes Research
Gary Hardiman, UCSD, The Transcriptional Genomics Core, Core C
New Frontiers in Sequencing
4:05-4:15 Tea/Coffee break
4:15-5:30
Selected talks on Islet Biology and T1DM
Chris Hampe, Univ. Washington
Anti-GAD Anti-idiotypic Antibodies in T1DM
Janet Wenzlau, Univ. Colorado, Denver
The Humoral Autoimmune Response to ZnT
Ellen Lumpkin, Baylor
Sensory Innervation and Pancreatic Function
Vijay Yechoor, Baylor
Auto-immunity Evading Neo-islets for Diabetes
Steven Chessler, UCSD
Neuroligin-Neurexin Interactions in Islet Function
5:30-6:30 Wine & Cheese and poster-session reception on patio
Endocrine Grand Rounds