Research interests in the laboratory include thyroid hormone action in the heart, especially, thyroid hormone-induced alterations in the transcription of the gene coding for the Ca2+ ATPase and the role which specific thyroid hormone receptor isoforms play in the heart. In addition, studies are pursued related to diabetic cardiomyopathy and the effects of excessive enzymatic protein glycosylation in cardiac myocytes and their influence on heart function. Also, studies are conducted related to the expression of specific heat shock proteins and protection of the heart against cardiac ischemia. Furthermore, the abnormal calcium transients occurring in hearts with heart failure is examined using transgenic animals.