Dorothy Sears, PhD

Dorothy D. Sears, PhD

Professor of Medicine

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My research focus is on obesity and risk for obesity-related diseases including insulin resistance, type 2 diabetes, cardiovascular disease, and cancer. My approach incorporates dietary and behavioral intervention, systems biology, lipidomics, metabolomics, epigenetics, expression profiling, and single gene analyses in humans and rodent models. My goals are to identify and characterize genes, metabolites, biochemical pathways, and behaviors that regulate and/or are biomarkers of cardiometabolic disease risk and which can be used as novel targets for disease risk reduction, therapy, and/or diagnosis.