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The Seaweed Canyon Cardiovascular Physiology Laboratory

Seaweed Cardiovascular Physiology Core Services

(Not limited to the following)

  1. Invasive left heart and right heart functions and pathological cardiac models studies:
    • Hemodynamics with or without pressure volume loops studies with various agents' injections. 
    • Blood pressure measurement in conscience mice with telemetry, in anesthetized mice with catheters.
    • Electrocardiogram (ECG) in conscience mice using telemetry, or under anesthetized with isoflurane
    • Intra-cardiac pacing with electric programing stimulation
    • Transverse aortic constriction (TAC) and post TAC pressure gradient measurements
    • Myocardial infarction
    • Ischemia reperfusion
    • Mini pump implantation
    • Neonatal mice apex resection
    • Aortic stenosis wire injury
    • Intra- cardiac, ventricles and venous injections of virus, cells or experiment agents.
    • Blood and tissue collections

       2.     None invasive cardiac function studies:

    •  Echocardiography: 
      • Pulsed-Wave Doppler (aortic flow and pulmonary flow)
      • 2D (chamber size and function, aortic arch size)
      • 4 Chamber view with Pulsed-Wave Doppler and Tissue Doppler
      • Strain Analysis
    • Other measurements
      • Tail cuff
      • Treadmill

 

Directors

Dr. Eric D. Adler and Dr. Ju Chen, Co-Directors, 2020-present

Dr. Kirk L. Peterson, Associate Director, 1988 – 2005, and Director, 2005-2020

Dr. John Ross, Jr., Director, 1972 - 2005

Dr. Eugene Braunwald, Director, 1968 - 1972

Dr. Dean Franklin, Founding Director, 1965-1970