Stein Research Institute Building
The above image must be cropped to 710px wide. We recommend a height of 75px to 200px; please keep the height consistent if you use this layout for other pages of your site.

UC San Diego Division of Geriatrics Research Publications

Stein_port1.jpgRead our article in Science


In December of 2007, our laboratory published the results of a study that sheds new light on cognitive disorders:

Behrens MM, Ali SS, Dao DN, Shekhtman JG, Quick KL and Dugan LL. (2008) Ketamine-induced loss of phenotypeof fast-spiking interneurons is mediated by NADPH-oxidase. Science. 318:1645-1647.

Read the article abstract


Peer-Reviewed Articles


  1. Quick KL, Hardt JI, Dugan LL. (2000) Rapid microplate assay for superoxide scavenging efficiency. J. Neurosci. Methods 97:139-144.
  2. Lobner D, Canzoniero LM, Manzerra P, Gottron F, Ying H, Knudson M, Tian M, Dugan LL, Kerchner GA, Sheline CT, Korsmeyer SJ, Choi DW. (2000) Zinc-induced neuronal death in cortical neurons. Cell Mol. Biol. 46:797-806.
  3. Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza R, Fryer JD, Kierson M, Cirrito J, Quick K, Harmony J, Aronow B, Holtzman DM. (2001) Clusterin/apolipoprotein J deficient mice: Decreased brain injury via a caspase-3 independent pathway in a model of cerebral palsy. Nat. Med., 7:338-343.
  4. Quick KL and Dugan LL. (2001) Superoxide stress identifies neurons at-risk in a model of ataxia-telangiectasia. Ann. Neurol. 49:627-635.
  5. Reichert SA, Kim-Han JS, Dugan LL. (2001) The mitochondrial permeability transition and nitric oxide synthase mediate early mitochondrial depolarization in astrocytes during oxygen-glucose deprivation. J. Neurosci., 21:6608-16.
  6. Kim-Han JS, Reichert SA, Dugan LL. (2001) BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production. J. Neurochem., 79:658-668.
  7. Xia S, Cai ZY, Thio LL, Kim-Han JS, Dugan LL, Covey DF, Rothman SM. (2002) The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiol. Dis. 9: 282-293.
  8. Sheline CT, Choi EH, Kim-Han JS, Dugan LL, Choi DW. (2002) Co-factors of mitochondrial enzymes attenuate copper-induced neuronal death in vitro and in vivo. Ann. Neurol. 52:195-204.
  9. De Erasquin GA, Hyrc K, Dorsey DA, Mamah D, Dokucu M, Masco DH, Walton T, Dikranian K, Soriano M, Verdugo JMG, Goldberg MP, Dugan LL. (2003) Nuclear translocation of nuclear transcription factor-κB by α-amino-3-hydroxy-5-methyl-4-isozolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons. Mol. Pharmacol. 63:784-90.
  10. Dasgupta B, Dugan LL, Gutmann DH. (2003) The neurofibromatosis 1 (NF1) gene product regulates PACAP-mediated signaling in astrocytes. J. Neurosci. 23:8949-54.
  11. Ali SS, Hardt JI, Quick KL, Kim-Han JS, Erlanger BF, Huang T-T, Epstein CJ, Dugan LL. (2004) A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties. Free Rad. Biol. Med. 37:1191-202.
  12. Cuddihy SL, Musiek ES, Morrow, JD, Dugan LL. (2004) Long-term vitamin E deficiency in mice decreases superoxide radical production in brain. Ann. N.Y. Acad. Sci. 1031:428-31.
  13. Kim-Han, JS, Kopp, SA, Dugan, LL*, Diringer, MN. (2006) Peri-hematomal mitochondrial dysfunction following intracerebral hemorrhage. Stroke 37:2457-2462. *Corresponding author.
  14. Quick, KL, Ali, SS, Arch, R, Xiong, C, Wozniak, D, Dugan, LL. (2006) A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiology of Aging, E-Pub 9/06, Print 29:117-28 (2008).
  15. Ali, SS, Xiong, C, Lucero, J, Behrens, MM, Dugan, LL*, Quick, KL. (2006) Gender differences in free radical homeostasis during aging: Shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell 5:565-74. *Corresponding author.
  16. Behrens, MM, Ali, SS, Dao, DN, Lucero, J, Shekhtman, G, Quick, KL, Dugan, LL. (2007) Brain NADPH-oxidase mediates ketamine effects on parvalbumin-expressing fast-spiking interneurons. Science 318:1645-7.
  17. Cuddihy, SL, Ali, SS, Musiek, E, Lucero, J, Kopp, S, Morrow, J, Dugan, LL. (2008) Prolonged α-tocopherol deficiency decreases oxidative stress and unmasks α-tocopherol-dependent regulation of mitochondrial function in brain. J. Biol. Chem., 283:6915-24.
  18. Sheline, C.T., Behrens, M.M. and Choi, D.W. 2000. Zinc-induced cortical neuronal death is associated with loss of NAD+ and inhibition of glycolysis. Journal of Neuroscience 20: 3139-3146.
  19. Moreno-Bueno, G., Calés, C., Behrens, M.M. and Fernández-Renart, M. 2000. Isolation and characterization of casein kinase I from Dictyostelium discoideum. Biochem. J. 349: 527-537.
  20. Manzerra, P., Behrens, M.M., Canzoniero, L.M.T., Wang, X-Q., Heidinger, V., Ichinose, T., Yu, S.P. and Choi, D.W. 2001. Zinc enhances NMDA receptor activation via a Src kinase family- mediated phosphorylation. Proc. Natl. Acad. Sci. USA. 98:11055-11061.
  21. Heidinger, V., Manzerra, P., Wang XQ, T., Yu, SP., Strasser, U., Choi, D.W., and Behrens, M.M. 2002. Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-family Kinase Pathway in Cortical Neurons. The Journal of Neuroscience 22:5452-5461.
  22. Bartfai T, Behrens MM, Gaidarova S, Pemberton J, Shivanyuk A, and Rebek, J. 2003. Low molecular weight mimic of TIR-domain inhibits interleukin 1 receptor-mediated responses: a new anti-inflammatory drug paradigm. Proc. Natl. Acad. Sci. USA 100: 7971-7976.
  23. Viviani B, Bartesaghi S, Gardoni F, Vezzani A, Behrens MM, Bartfai T, Binaglia M, Corsini E, DiLuca M, Galli CL, Marinovich M. 2003. Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases. The Journal of Neuroscience 23:8692-8700.
  24. Kim HJ, Hwang JJ, Behrens MM, Snider BJ, Choi DW, Koh JY. 2003. TrkB mediates BDNF-induced potentiation of neuronal necrosis in cortical culture. Neurobiology of Disease 14:110-119.
  25. Tabarean IV, Behrens MM, Bartfai T, Korn H. 2004. Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition. Proc. Natl. Acad. Sci. USA 101: 2590-2595.
  26. Dube C, Vezzani A, Behrens M, Bartfai T, Baram TZ. 2005. Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol. 57:152-155.
  27. Lu X, Barr AM, Kinney JW, Sanna P, Conti B, Behrens MM and Bartfai T. 2005. A role for Galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc. Natl. Acad. Sci. USA 102:874-879.
  28. Conti B, Sugama S, Lucero J, Wirz SA, Winsky-Sommerer R, Maher P, Paneda C, Barr AM, Morale MC, Sanna PP, Pemberton J, Gaidarova S, Behrens MM, Beal F, Andrews Z, Horvath T, Bartfai T. 2005. UCP2 protects catecholaminergic neurons from acute MPTP toxicity. J. Neurochemistry 93:493-501.
  29. Badie-Mahdavi H, Lu X, Behrens MM and Bartfai T. 2005. Role of GalR1 and GalR2 activation in Synaptic Plasticity Associated with CREB Phosphorylation in the Dentate Gyrus: Studies with a GalR2 Selective Agonist and GalR1 Knockout Mice. Neuroscience 133(2):591-604.
  30. Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T. 2005. Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides 39(3):249-51.
  31. Tabarean IV, Conti B, Behrens MM, Gaidarova S, Pemberton J and Bartfai T. 2005. Electrophysiological characterization of preoptic area/anterior hypothalamus neurons in culture. Neuroscience 135:433-449.
  32. Kinney JW, Davis CN, Conti B, Bartfai T, Behrens MM. 2006. A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. The Journal of Neuroscience 26:1604-1615.
  33. Davis CN, Mann E, Behrens MM, Gaidarova S, Rebek M, Rebek J-Jr, Bartfai T. 2006. MyD88 dependent and independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 domain/BB loop mimetics. Proc. Natl. Acad. Sci. USA. 103:2953-2958.
  34. Sanchez-Alavez M, Tabarean I, Behrens MM, Bartfai T. 2006. Ceramide mediates the rapid phase of febrile response to Interleukin-1 Proc. Natl. Acad. Sci. USA. 103:2904-2908.
  35. Conti B, Davis CN, Behrens MM, Rebeck J and Bartfai T. 2006. Toll-like receptors as pharmacological targets. In “TLRs in inflammation”.LAJ O’Neill &E Brint Editors; Birkhauser Verlag, Basel, Boston, Berlin; pp 223-240.
  36. Davis CN, Behrens MM, Tabarean I, Gaidarova S, Bartfai T. 2006. IL-1β induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. Journal of Neurochemistry 98:1379-1389.
  37. Ali, SS, Xiong, C, Lucero, J, Behrens, MM, Dugan, LL, Quick, KL. 2006. Gender differences in free radical homeostasis during aging: Shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell 5:565-574.
  38. Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL, Dugan LL. 2007. Ketamine-induced Loss of Phenotype of Fast-Spiking Interneurons is Mediated by NADPH-oxidase. Science 318:1645-1647.
  39. Conti B, Tabarean I, Sanchez-Alavez M, Davis C, Brownell S, Behrens MM and Bartfai T. 2008. Cytokine Receptors in the Brain. In “Cytokines and the Brain”. Edited by C. Phelps and E. Korneva. Elsevier B.V. in press.
  40. Kinney JW, Sanchez M, Barr AM, Criado JR, Crawley JN, Behrens MM, Henriksen SJ, and Bartfai T. 2008. Impairment of Memory Consolidation by Galanin Correlates with In-Vivo Inhibition of Both LTP and CREB Phosphorylation. Submitted to Eur. J. Neurosci.
  41. Behrens MM, Ali SS, Dugan LL. 2008. Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. Submitted to Science.
  42. Ali SS, Behrens MM, Quick KL, Lucero J, Zheng L, Dugan LL. 2008. Increased neuronal superoxide production in aging brain derives from NADPH oxidase and mediates loss of critical inhibitory interneurons. Submitted to Nature Medicine.
  43. Behrens MM, Ali SS, Dugan LL. 2008. Age-related vulnerability of prefrontal cortical interneurons to the effects of ketamine. Submitted to Proc. Natl. Acad. Sci. USA.
  44. Zhang Y, Behrens MM, Lisman J. 2008. Prolonged Exposure to NMDAR Antagonist Suppresses Inhibitory Synaptic Transmission in Prefrontal Cortex. Submitted to J. Neurophysiology.
  45. Abdel-Mottaleb M, Galal HR, Dessouky AFM, El-Naggar M, Mekkawi D, Ali SS and Attya GM. (2000) Fluorescence and photostability studies of anthracene-9-carboxylic acid in different media, International Journal of Photoenergy, 2:47.
  46. Ali SS, Maeda K, Murai H and Azumi T. (2003) Electron-Transfer Reaction of 4,4’-Bipyridine with Triethylamine in Acetonitrile: A Dramatic Water Effect on the Reaction Dynamics. Res. Chem. Intermediates 1:1-10.
  47. Fayed TA and Ali SS. (2003) Protonation Dependent Photoinduced Intramolecular Charge Transfer in 2-(p- Dimethylaminostyryl) Benzazoles. Spectroscopy Lett. 36:375.
  48. Ali SS, Hardt JI, Quick KL, Kim-Han JS, Erlanger BF, Huang T, Epstein CJ and Dugan LL. (2004) A Biologically Effective Fullerene (C60) Derivative with Superoxide Dismutase Mimetic Properties. Free Rad. Biol. Med., 37:1191-1202.
  49. Ali SS, Xiong C, Lucero J, Dugan LL, Quick KL. (2006) Gender differences in free radical homeostasis during aging: Shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell, 5(6) 565-574.
  50. Kevin L. Quick KL, Ali SS, Arch R, Xiong C, Wozniak D, Dugan LL. (2006) A carboxyfullerene SOD mimetic extends the lifespan of mice. Neurobiology of Aging, Neurobiology of Aging, E-Pub 9/06, Print 29:117-28 (2008).
  51. Kim-Han JS, Ali SS, and Dugan LD. (2006) Uncoupling Proteins. In: Handbook of Neurochemistry and Molecular Neurobiology, Gison and Dienel, eds., Kluwer Academic/Plenum Publishing, New York, NY.
  52. Abdel-Shafi AA, Bourdelande JL, and Ali SS. (2007) Photosensitized generation of singlet oxygen from rhenium(I) and iridium(III) complexes. Perkin Transactions. DOI: 10.1039/b705524b.
  53. Behrens, MM, Ali, SS, Dao, DN, Lucero, J, Shekhtman, G, Quick, KL, Dugan, LL. (2007) Brain NADPH-oxidase mediates ketamine effects on parvalbumin-expressing fast-spiking interneurons. Science 318:1645-7.
  54. Cuddihy, SL, Ali, SS, Musiek, E, Lucero, J, Kopp, S, Morrow, J, Dugan, LL. (2008) Prolonged α-tocopherol deficiency decreases oxidative stress and unmasks -tocopherol-dependent regulation of mitochondrial function in brain. J. Biol. Chem., In Press. Doi/10.1074/jbc.M702572200.