Yoga is a vast and heterogeneous set of practices. This heterogeneity, while reflecting the richness and diversity of yogic approaches, also makes comparison of findings across studies difficult and limits our ability to understand the mechanisms through which yoga therapy affects the mind, body, and overall well-being. To advance understanding of the efficacy of yoga therapy, the EPYQ was developed to quantify and describe the essential dimensions present in yoga interventions. The EPYQ can be used with any style of yoga and across patient or participant populations. This measure will allow yoga interventions research to examine the effects of various dimensions of yoga on well-being and to design more effective interventions for various health problems.