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Education, Fellowships and Publications

Dr. Anna Di Nardo graduated with honors in 1986 from the University of Pavia School of Medicine ( Italy). She trained as a dermatologist and was Board certified in Dermatology at the University of Modena Medical school (Italy) in 1989. In 1994, she obtained her Ph.D. diploma in Immunology and Clinical Allergology from the Ministry of University and Scientific Research in Italy (mentor: Dr. Giannetti). She practiced Dermatology in Italy for 10 years at the University of Modena. Since 2008 she has been ECFMG certified and has held an unrestricted California medical license. She practices Dermatology at UCSD
August 1989 - December 1989: Department of Dermatology, Skin Pharmacology, Institute of Human Pharmacology, Schering A&G- Berlin, Germany Schering Fellowship
June 1992 - March 1993: Department of Dermatology, School of Medicine, University of California San Francisco, Skin Barrier, Fellowship (Mentor: Dr. Maibach)
August 2000 - January 2001: Department of Dermatology, School of Medicine, University of California San Francisco, Skin Barrier, Fellowship (Mentors: Dr. Holleran, Dr. Elias)
January 2001 - January 2006: Department of Medicine Dermatology section, School of Medicine, University of California San Diego, Antimicrobial Peptide Fellowship (mentor: Dr Gallo)

Selected Publications

Botulinum toxin blocks mast cells and prevents rosacea like inflammation.
Choi JE, Werbel T, Wang Z, Wu CC, Yaksh TL, Di Nardo A.
J Dermatol

Skin microbiome and mast cells.
Igawa S, Di Nardo A.
J Invest Dermatol

TRPV4 Mediates Mast Cell Activation in Cathelicidin-Induced Rosacea Inflammation.
Mascarenhas NL, Wang Z, Chang YL, Di Nardo A.
J Invest Dermatol

Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea
Muto Y, Wang Z, Vanderberghe M, Two A, Gallo RL, Di Nardo A
J Invest Dermatol

Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes.
Wang Z, Mascarenhas N, Eckmann L, Miyamoto Y, Sun X, Kawakami T, Di Nardo A.
J Allergy Clin Immunol

Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides
Wang Z, Lai Y, Bernard JJ, Macleod DT, Cogen AL, Moss B, Di Nardo A
J Immunol

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons
Gregorio J, Meller S, Conrad C, Di Nardo A, Homey B, Lauerma A, Arai N, Gallo RL, Digiovanni J, Gilliet M
J Exp Med

Immunotherapy for melanoma: current status and perspectives
Alexandrescu DT, Ichim TE, Riordan NH, Marincola FM, Di Nardo A, Kabigting FD, Dasanu CA
J Immunother

Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections
Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL
J Invest Dermatol

Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury
Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL
Nat Med

Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37 Park HJ, Cho DH, Kim HJ, Lee JY, Cho BK, Bang SI, Song SY, Yamasaki K, Di Nardo A, Gallo RL
J Invest Dermatol

Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin
Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL
J Immunol

Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL
Nat Med

Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on toll-like receptor 4, cd44, and md-2
Taylor KR, Yamasaki K, Radek KA, Di Nardo A, Goodarzi H, Golenbock D, Beutler B, Gallo RL
Journal of Biological Chemistry

Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization
Di Nardo A, Braff MH, Taylor KR, Na C, Granstein RD, McInturff JE, Krutzik S, Modlin RL, Gallo RL
J Immunol

Augmentation of cutaneous immune responses by ATP gamma S: purinergic agonists define a novel class of immunologic adjuvants
Granstein RD, Ding W, Huang J, Holzer A, Gallo RL, Di Nardo A, Wagner JA
J Immunol

Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities
Braff MH, Hawkins MA, Di Nardo A, Lopez-Garcia B, Howell MD, Wong C, Lin K, Streib JE, Dorschner R, Leung DY, Gallo RL
J Immunol

Keratinocytes Store the Antimicrobial Peptide Cathelicidin in Lamellar Bodies
Braff MH, Di Nardo A, Gallo RL
J Invest Dermatol

Cutting edge: mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide
Di Nardo A, Vitiello A, Gallo RL
J Immunol