Dear Past Goldstein Lab Members,
I was very fortunate to be elected to the U.S. National Academy of Sciences on April 27, 2020. This is a very nice honor that I want to be sure to share with all of the past and present members of our lab. You all contributed in important ways and I certainly would not have been elected without all of the great scientific research you accomplished while working with our group. Thank you to all of you! I hope you are all healthy and safe.
Establishment of the Lawrence Goldstein Science Policy Fellowship in Honor of Director Emeritus
The International Society for Stem Cell Research (ISSCR) recently honored Lawrence Goldstein, PhD, Distinguished Professor in the department of cellular and molecular medicine and neurosciences at UC San Diego and Director Emeritus at Sanford Stem Cell Clinical Center, at its annual conference in Los Angeles for his years of science policy advocacy. The organization also announced a new program in his name, the Lawrence Goldstein Science Policy Fellowship, which will train ISSCR members to become stem cell policy advocates.
“The society has long appreciated Larry’s willingness to speak out in support of stem cell research and regenerative medicine, even in challenging social and political times,” said ISSCR president Douglas Melton.“Larry has made a significant impact on the field and changed many hearts and minds. He exemplifies for scientists the important role our voices play in public debate, in ensuring that scientific evidence and facts are at the heart of any conversation about stem cells and their translation to medicine.”
For the last 25 years, Dr. Goldstein has been a faculty member and principal investigator of a biomedical research laboratory at UC San Diego School of Medicine. He also founded and directed the UCSD Stem Cell Program and the Sanford Stem Cell Clinical Center and is the founding scientific director of the Sanford Consortium for Regenerative Medicine. Goldstein co-chaired the scientific advisory board for California’s Proposition 71 that established $3 billion for stem cell medical research in the state. Throughout his career, Goldstein has advocated for science before local, state, and national policymakers on issues such as decisions about funding levels, and guidelines and ethical standards for research using stem cells, fetal tissue, and other matters.
The Lawrence Goldstein Science Policy Fellowship started accepting applications in June 2019. Information about submitting an application for the program is available at ISSCR.org.
The primary goals in the Goldstein lab are to unravel how molecular motors interact with and control the behavior of, axonal vesicles, and to relate this understanding to the molecular basis of neuronal defects in Alzheimer's Disease (AD) and Niemann Pick type C disease.
We are taking advantage of pluripotent stem cell lines that contain known mutations that cause hereditary Alzheimer's disease, as well as Niemann Pick Type C disease. This latter disease is of interest because it directly ties cholesterol trafficking and transport to what appears to be a pediatric form of Alzheimer type dementia.
We are also using these cell lines and animal models to probe basic mechanisms of vesicle movement and sorting in neurons, and how such mechanisms inter-relate with disease development. In a related endeavor, we are probing how genetic variation predisposes to different neuronal phenotypes and disease by developing pluripotent stem cell lines carrying genomes of people who developed sporadic Alzheimer's disease or in one case carry susceptibility elements (from Craig Venter whose diploid genome is completely sequenced and which is known to harbor Alzheimer susceptibility variants).
To study these problems, we have collaborated with BD biosciences to develop new quantitative methods for generating and purifying neurons made from human embryonic stem cells and induced pluripotent stem cells. We have also developed quantitative methods for evaluating AD phenotypes in these cells.
Stem Cells and Alzheimer's Disease - On Our Mind
A: UCSD School of Medicine, 9500 Gilman Drive, MC 0695, La Jolla, CA 92093-0695 | T: 858-534-9700 | E: firstname.lastname@example.org Lab: Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, Rm 3808, La Jolla, CA 92037 | T: 858-534-9703