|The San Diego Union Trubune – Lawrence Goldstein, PhD, "Scientist to California: Fund research like a nation" 7/16/2013|
La Jolla — California's boosters like to compare its economic statistics to other nations. The message is that California's economy is more like a nation than a state.
|The San Diego Union Tribune - Unproven stem cell treatment fause for alarm. 5/13/2013|
|UCSD News - "Finding Cures for Devastaing Diseases" 8/2/2012|
Pradeep Khosla capped off his first day as UC San Diego chancellor by touring the Sanford Consortium for Regenerative Medicine, a new, state-of-the-art stem cell research facility dedicated to research and finding cures and therapies for some of society's most devastating diseases. Read more
|Reuters - "Programmed Cells: from Basic Neuroscience to Therapy" 4/3/2012|
"Another advantage of both induced pluripotent cells and direct reprogramming of fibroblasts to neurons is that the donor cells can come from individual patients, so the cells that are generated have the same constellation of gene polymorphisms. This is being put to good use in experiments investigating the basic mechanisms of various diseases of the nervous system, as well as testing for potential therapeutic compounds. Cells taken from patients with familial Alzheimer's disease are being used to probe the effects of specific mutations on neuron function (Lawrence Goldstein, Howard Hughes Medical Institute, La Jolla, USA). By comparing such cells with those from patients with the non-genetic form of the disease, common disease mechanisms may be discovered."
|The Sacramento Bee - "The Conversation: These cells could save lives. But when? And at what cost?" 2/12/2012|
Should California maintain its leadership in stem cell research and continue funding the California Institute for Regenerative Medicine? "We are at a time when venture capital doesn't invest as early as it used to," said Larry Goldstein, a leading stem cell scientist at UC San Diego. "So the public has to do it. You may not like the system, but that's the system."
Nature News - "Alzheimer's 'in a dish' shows promise" 1/25/2012
ABC News - "Stem Cell Tech May Aid Alzheimer's Research" 1/25/2012
Mirror - "Scientists grow Alzheimer's cells for the first time - and hope it will prove treatment breakthrough" 1/25/2012
Dailymail - "Hope for dementia patients after Alzheimer's cells created in lab for first time" 1/25/2012
Express - "HOPE FOR ALZHEIMER'S CURE AS 'DEMENTIA NERVES' CREATED IN LAB" 1/25/2012
UCSD News - "Researchers Induce Alzheimer's Neurons From Pluripotent Stem Cells" 1/25/2012
|Akron News Now - "Stem-Cell Tech May Aid Alzheimer's Research" 1/25/2012|
Fox News - "Researchers replicate Alzheimer's disease neurons with stem cells" 1/25/2012
KBOI - "Stem-Cell Tech May Aid Alzheimer's Research" 1/25/2012
E! Science News - "Researchers induce Alzheimer's neurons from pluripotent stem cells" 1/25/2012
Alzheimer's Reading Room - "Scientists Replicate Alzheimer's Neurons Using Stem Cell Technology" 1/25/2012
The San Diego Union-TRIBUNE - "Stem cell research: no laughing matter" 1/26/2012
HealthCanal - "Researchers Induce Alzheimer's Neurons From Pluripotent Stem Cells" 1/26/2012
Genetic Engineering News on "iPSC-Derived Neurons Shine New Light on Sporadic vs. Familial Alzheimer Disease" 1/26/2012
Inventorspot - "Stem Cell Technology Used To Create Neuronal Model For Alzheimer's Disease" 1/26/2012
News-Medical.net - "Breakthroughs in Alzheimer's disease research" 1/26/2012
The North County Times - "Alzheimer's brain cells grown from patients' skin cells could model disease" 1/26/2012
Truthdive - "Stem cell-derived neurons may help find cause of Alzheimer's" 1/26/2012
HealthCanal - "Stem cell technology reveals clues to Alzheimer's" 1/27/2012
Bioscience Technology - "Researchers Induce Alzheimer's Neurons From Pluripotent Stem Cells" 1/27/2012
Domain-B - "Researchers induce Alzheimer's neurons from pluripotent stem cells" 1/27/2012
Bionity - "Researchers induce Alzheimer's neurons from pluripotent stem cells" 1/27/2012
El Indepiendte De Canarias - "Desarrollan un nuevo método para entender la causa del Alzheimer" 2/2/2012
Nature Reviews Neuroscience - "Neurodegenerative disease: Dishing up Alzheimer's disease" March 2012, 13:149
Cell Stem Cell - "iPSCs to the Rescue in Alzheimer's Research" 2 March 2012, 10:235
|Weird Science - "Inside the Strange Science of Cord Blood Banking" 12/8/2011|
For parents, the details of cord blood use aren't always clear, said Dr. Lawrence Goldstein, a University of California, San Diego cell biologist and author of Stem Cells for Dummies. Read more
|Yahoo! News - "Scientists Clone Embryonic Stem Cells from Individuals to Aid in Cure for Diabetes" 10/8/2011|
"I think it will teach us a lot about how to control the generation of all the different cell types that we would like to study and use for therapy," said Lawrence Goldstein, the director of the stem cell research program at the University of California at San Diego. "I think it's a really exciting development."
|Peyton Manning's stem cell therapy 09/19-9/22/2011|
"World's top stem cell researchers in Pasadena for conference 10/3-10/4/20111
The North County Times: "Stem cell summit explores stem cell therapy's progress, obstacles" 10/3/2011
KPCC: "World's top stem cell researchers in Pasadena for conference" 10/4/2011
ABC News: "Peyton Manning's Stem Cell Hail Mary" 9/19/2011
The Huffington Post: "Peyton Manning Underwent Stem Cell Treatment For Neck Injury" 9/19/2011
The Atlantic Wire: "Don't Tell Injured NFL Players Stem Cell Tourism Is a Bad Idea" 9/20/2011
Yahoo! News: "How safe is Peyton Manning's stem cell therapy?" 9/22/2011
MSNBC: Peyton Manning's treatment: How safe is it? 9/21/2011
The Week: How safe is Peyton Manning's stem cell therapy? 9/22/2011
|The San Diego Union Tribune – "UCSD's Goldstein – Too little spent on Alzheimer's research" 9/7/2011|
We asked Lawrence Goldstein, director of the UC San Diego Stem Cell Program, to provide a bit of perspective on the amount of money being spent to find treatments for Alzheimer's disease. Goldstein, who is also a Howard Hughes Medical Institute Investigator, said:
"We are spending less than $1 billion on research from the major funding agency (National Institute of Health) to find effective treatments to try to solve a problem that is costing us trillions over the course of a few more years. Read more
|USA Today – "Doctorsoffer unapproved stem cell therapies" 6/28/2011|
"We'd all love easy miracles," says Larry Goldstein, head of stem cell research at the University of California-San Diego. "That's not the way it works."
... FDA regulations have loopholes, Goldstein says. FDA guidelines limit its authority to regulate treatments involving cells that are withdrawn from a patient and then infused the same day with only "minimal manipulation." Last August, in a test of its authority, the FDA requested an injunction from the U.S. District Court in Washington, D.C., to block a Broomfield, Colo., orthopedic clinic, Regenerative Sciences, from formulating treatments of cultured stem cells.
|The Detroit News - "Family looks to China for child's stem cell treatment" 6/7/2011|
... while stem cell research holds profound promise and is constantly advancing — the first embryonic stem cell-based treatment for acute spinal cord injuries, for example, has been authorized by the Food and Drug Administration for Phase 1 clinical trials — the only proven uses now are for bone marrow transplants and to treat some bone, skin and corneal diseases, according to the International Society for Stem Cell Research.
"After that, everything is experimental," said Larry Goldstein, director of the University of California, San Diego, Stem Cell Program.
|The San Diego Union Tribune – "UCSD researchers find problem with stem cells grown from skin" 5/13/2011|
"This paper, if validated by others, tells us that is not true," said Larry Goldstein, who heads the stem cell research program at UCSD but wasn't involved in the work. "That problem will have to be solved in developing (the stem cells) for transplantation therapy." Read more
|Nature - iPS cell mutations 3/3/2011|
The San Diego UNION-TRIBUNE - "San Diego researchers shed light on gene mutations in stem cells" 3/2/2011
ScienceDaily - "Mutations Found in Human Induced Pluripotent Stem Cells" 3/2/2011
|North County TImes - "BIOTECH: More evidence of possibly dangerous mutations in artificial stem cells" 3/2/2011|
UCSD News - "Mutations Found In Human Induced Pluripotent Stem Cells" 3/2/2011
MIT Technology Review - "Reprogrammed Stem Cells Are Rife with Mutations" 3/3/2011
Dr. Goldstein and Sandra and their work on Prion (published in the journal Cell on 2/18/2011
UCSD News - "Unraveling How Prion Proteins Move Along Axons to the Brain" 2/17/2011
BiomedME - "Improving Understanding Of The Spread Of Infectious Prions" 2/20/2011
ScienceDaily - "Unraveling How Prion Proteins Move Along Axons in the Brain" 2/22/2011
|The San Diego Union Tribune – "UCSD stem cell researchers get $5.6 million from state" 1/27/2011|
At UCSD, a research team headed by Larry Goldstein received $1.8 million to continue developing a way to mass-produce active stem cells, known as induced pluripotent stem cells, from dormant stem cells found in adult human tissue. Steady supplies of induced cells will give other researchers a faster and lower-cost way for testing new drugs for disease associated with genetic mutations, such as Alzheimer's disease, said Goldstein, who directs the university's stem cell program.
|The Huffington Post – "Rescuing Cognition: California Versus Alzheimer's Disease" 1/25/2011|
One champion is Dr. Larry Goldstein at UC San Diego. If you ever have the chance to hear Larry Goldstein speak, don't miss it. He makes the research understandable, while never sugar-coating the tremendous difficulties of research for cure.
Using embryonic stem cells, he is working to develop a cellular model of Alzheimer's in a Petri dish. Think what this could mean. Right now scientists can only learn from patients when they are in the advanced stages of the disease -- their disease may have begun decades earlier -- not to mention it is unlikely for anyone to volunteer to donate a piece of their living brain. Read more
|The Fort Worth Star-Telegram – "Couple's search for hope leads to controversial treatment in China" 12/12/2010|
Researchers such as Dr. Lawrence Goldstein, who is on the board of the International Society for Stem Cell Research, empathize with families who are desperate for a cure. But they balance that with reality: It takes time to do research properly. Stem cell therapies have been proved effective only for blood disorders such as leukemia and some skin conditions. Read more
|The Sacramento Bee- Larry Goldstein author's "Promise is worth the risk of stem cell agency" . 11/29/2010)|
California's ambitious landmark stem cell research program has been criticized as a bad bet for taxpayers. As a scientist and one of the architects of the California Institute for Regenerative Medicine, I agree that steering between an over-optimistic view of what is possible and a hyper-pessimistic commitment to inaction can be difficult. But – viewed against scientific principles, medical need, history and logic – the state's stem cell agency is a calculated but not reckless risk, and it is not merely a bet on a narrow research avenue.
|Los Angeles Business Journal – Stem cells take Root in Koreatown" 11/15/2010|
Larry Goldstein, director of UC San Diego's stem cell program and a board member of the International Society for Stem Cell Research, cautioned against unapproved medical uses of stem cells.
"Anybody can go on a street corner and declare they have a cure for anything," he said. "Sometimes you find out there are dangers to patients that you didn't anticipate, which emphasizes why it's so important to do careful clinical experimentation before selling it to large numbers of people."
|The San Diego Union Tribune - "The best birthday gift for UCSD". 11/18/2010|
The 50th anniversary of UC San Diego invites assessment of the value of our campus to the region and to California. In particular, at a time of great fiscal stress in the state budget, when every dollar allocated and spent should be examined, we must ask whether our community and state extract appropriate value from its contribution. Read more
|KPBS – "San Diego Researchers Jarred by Stem Cell Ruling". 8/24/2010|
|The San Diego Union Tribune – "Local reaction to stem cell ruling" 8/24/2010|
"The ruling is terrible news, not only for scientists trying to find therapies using human embryo stem cells, but also for people who depend on us to move as quickly as possible to find those therapies," said Larry Goldstein, who heads the stem cell research program at the University of California San Diego. Read more
Sacramento Bee – "Beware stem cell “cures” doctors say" 8/8/2010
"The world is full of clinics and pseudo practitioners who
would offer 'treatments' for conditions that cannot be treated," said
Larry Goldstein, director of the UC San Diego Stem Cell Program and a board
member of the International Society for Stem Cell Research.
|ABC News – "Stem Cell-Engineered Windpipe for Cancer Patients" 8/2/2010|
|The Wall Street Journal - "Universities Bank on Stem-Cell Research"|
|The Jolla Light – "UCSD team gets 11.5 million for stem cell research on Lou Gehrig's disease" 6/29/2010|
Embracing the concept that the whole is greater than the sum of its individual parts, an $11.5 million "disease team" grant has been awarded to UC San Diego to fast track stem-cell research on Amyotrophic Lateral Sclerosis (ALS) - also known as Lou Gehrig's Disease. The goal is to advance basic research to human clinical trials within four years.
Funding is from the California Institute for Regenerative Medicine (CIRM), the state stem-cell agency created by voter passage of proposition 71. In a public meeting on June 23, local scientists, health advocates and CIRM leadership described the grant's research focus.
ALS is a progressive, fatal disease in which motor neurons, the nerve cells that control voluntary muscle contractions, simply die. Over time, ALS leads to extreme muscle weakness, paralysis, and death.
"Like most cells in the body, motor neurons do not live in isolation; they live in an environment, surrounded by other type of non-neuron cells," said Larry Goldstein, Ph.D., professor of cellular and molecular medicine at UCSD School of Medicine, Howard Hughes Medical Institute Investigator and director of the UCSD Stem Cell Program.
"Therefore, one of the ways you might image to eliminate (disease) spread would be by supporting the 'neighborhood' rather than replacing the neurons themselves."
This has led to interest in exploiting a special type of cell called an astrocyte progenitor. Astrocytes are glial cells, a family of cells that support the proper functioning and insulation of neurons. Astrocytes, in particular, help with neurotransmissions and neuronal metabolism. Previous studies indicate that transplanting healthy glial cells into patients could be a possible treatment for ALS, and animal studies have shown that astrocytes possess particular promise in this regard.
Co-principal investigators on the grant are Goldstein, Martin Marsala, M.D., professor in the UCSD School of Medicine's department of anesthesiology, and Sam Pfaff, Ph.D., a professor in the Salk Institute's Gene Expression Laboratory. They will lead researchers in studies of two methods of administering progenitors in animal models and test the safety and efficacy of these approaches, with the goal of providing proof-of-principle and laying the groundwork for clinical trials.
"Any novel treatment option would not only be clinically competitive, but could have a major impact for thousands of patients currently battling this disease," Don Cleveland, Ph.D., professor of Medicine, Neurosciences and chair of the UCSD Department of Cellular and Molecular Medicine, stated in a press release. Cleveland is also head of the Laboratory of Cell Biology at the Ludwig Institute for Cancer Research based at UCSD. "This approach has the potential to lead to the development of new therapies that could significantly extend the lifespan of individuals living with this disease, and improve their quality of life."
In addition to basic research, animal data, and pre-clinical aspects of the studies, another disease-team member is Carlsbad-based Life Technologies Corp. which will provide expertise in stem-cell biology, cell separation, next-generation sequencing, and scalable bioproduction.
"The goal is to develop a clinically compliant process for preparation of human astrocyte precursors," said Mark Bonyhadi, Ph.D., director of clinical business development for cell therapy systems at Life Technologies.
Approximately 30,000 people in the United States are affected with ALS with 5,600 new cases diagnosed each year. The causes of ALS are unknown; there is no cure. Only one drug - Rilutek - is currently approved by the Food and Drug Administration for treating ALS. Rilutek extends the lifespan of ALS patients by a maximum of three months.
|CBS 60 Minutes – "21st Century Snake Oil" 4/18/2010|
"60 Minutes" hidden cameras expose medical conmen who prey on dying victims by using pitches that capitalize on the promise of stem cells to cure almost any disease. Read more
UCSD News - "Stem Cell Myth Buster" 4/12/2010
Research pioneer uses 'Stem Cell for Dummies' book to dispel misconceptions about stem cell research by Ioana Patringenaru Read
The San Diego Union Tribune - "The stem cellsman: Lawrence Goldstein" 3/22/2010 Read
|CBS Evening News – "Stem Cells Cures Any Closer" 3/16/2010|
|KPBS – "Mysteries of Stem Cells" 3/2/2010|
|Stem Cells for Dummies by Lawrence Goldstein and Meg Schnieder|
News about the book:
Stem Cells 101 in HHMI Bulletin
At UCSD bookstore, LG discusses and signs his book "Stem Cells for Dummies" on April 15 @ 12:30pm .
"UCSD researcher pens 'Stem Cells for Dummies' " by La Jolla Light (2/28/2010)
LG discusses and signs "Stem Cells for Dummies" at The Book Works (3/2/2010)
Stem Cells For Dummies: The Controversy, Pros and Cons, Facts, Future Research
Stem Cells For Dummies: Cheat Sheet
Stem Cells For Dummies: Book Information
The book is on sale at Amazon, Barnes & Noble, and other book stores.
|UCSD News – "Three UC San Diego Researchers Receive Top National Awards" 11/24/2009|
ASCB is honoring LG for his "dedication in advocating for biomedical research funding and research policy issues around the country. During the past decade, Goldstein has spent numerous hours explaining why government funding of stem cell research is important, and sharing his expertise with members of Congress and the media to help them understand the complicated science behind stem cell legislation."
Locally, LG has served as a national leader in stem cell research and policy, including serving as co-chair of the scientific advisory committee for the campaign to pass California's Proposition 71, a voter-endorsed measure to provide $3 billion in stem cell research funding in California. LG has also appeared on numerous occasions before the California legislature and the U.S. Congress and Senate to testify in support of stem cell research and biomedical research funding. Read more
|San Diego Union Tribune – "Stem cell project still finding its way" 11/12/2009|
As California's $3 billion stem cell program passes its fifth anniversary, the challenges remain great.Much of San Diego's stem cell community gathered in La Jolla yesterday for the annual "Stem Cell Meeting on the Mesa," and there was a lot of talk about big ideas and exciting experiments.But there was also caution about not over-promising in terms of how quickly the work will pay off, and what form stem cell products will take if they do ultimately emerge.
Larry Goldstein, director of the stem cell program at the University of California San Diego, told the audience of at least 200 people that the next five years could see treatments start to emerge for a range of conditions.But those five years will require testing various approaches to steadily improving the understanding of stem cell science. While there are a lot of promising ideas in the stem cell field, it's not clear which will work.
"This is going to be tough," Goldstein said. "There's no sugar-coating this." Read more
|KPBS - "San Diego Researchers Applaud Stem Cell Order" 3/9/2009|
San Diego's researchers say a boost in embryonic stem cell funding will advance the search for cures at many local institutions. KPBS Radio's Tom Fudge has more.
President Obama yesterday rescinded an eight-year-old restriction on funding for embryonic stem cell research. And that was good news to San Diego's research institutions, which received hundreds of millions of dollars from the National Institutes of Health. Critics of the research say destroying embryos for their stem cells is immoral, even if it may lead to cures for deadly diseases. Larry Goldstein is the director of UCSD's stem cell program. He says funding will still be limited by rules about how embryos are acquired.
Goldstein: I can well imagine that of the hundreds of cell lines that are currently available, there may be some where there are ethical questions about how they were generated. And therefore they may not be eligeble, and that's fine. The law still prohibits federal funds from being used to harvest new stem cell lines. Tom Fudge, KPBS news.
|Dr. Lawrence Goldstein named Fellow of the Prestigious American Academy of Arts and Sciences 5/5/2008|
Seven scholars from the University of California, San Diego were recently named Fellows of the prestigious American Academy of Arts and Sciences: four from the School of Medicine, and one each from economics, anthropology and the Scripps Institution of Oceanography. The American Academy of Arts & Sciences honors the country's leaders in scholarship, business, the arts and public affairs. New members will be formally welcomed into the Academy at an Induction Ceremony in Cambridge, Massachusetts, on October 11, 2008. The new UC San Diego fellows includes Larry Goldstein, Ph.D., professor in the Department of Cellular & Molecular Medicine at the UC San Diego School of Medicine, a Howard Hughes Medical Institute (HMMI)Investigator and director of the UC San Diego Stem Cell Program. Read more
|The San Diego Union Tribune - "Stem cell research focus of meeting" 11/8/2008|
Using an old photograph of California Gov. Arnold Schwarzenegger in his acting days as Conan the Barbarian, University of California San Diego professor Larry Goldstein explained the complex and lengthy road over which the body's neurons must transmit signals to synapses in the feet and hands, and all that could go wrong in between. Using human embryonic stem cells, scientists in Goldstein's lab are creating human models of Alzheimer's disease to determine the role of environmental and genetic damage. It's one disease that requires a human model, Goldstein said, because mice and other animals don't get it.
"Who can tell if a mouse is demented anyway?" Goldstein said. Through its work, Goldstein's team learned that the best models are created by coaxing skin cells from people with Alzheimer's to go backward down the development chain until they are pluripotent, meaning they are like embryonic cells in having the capacity to evolve into many cell types. These so-called induced pluripotent cells are then coaxed to develop forward again, into diseased neurons. Read more
|KUSI – San Diego People with Kimberly Hunt 9/2/2007|
Larry Goldstein and KUSI news anchor Kimberly Hunt discuss the basics of stem cells: How are they derived? What do they do and why are stem cells important? What diseases do scientists hope to treat or cure?
Importantly, the program covers specific stem cell research projects at UCSD, and why San Diego is one of the best places in the world for stem cell research.
|Charlie Rose – Science Series 5/16/2007|
This fifth episode of the Charlie Rose Science Series is an exploration of one of the most promising fields of science: stem cell research. Our panel discusses existing successes in the use of stem cells, such as bone marrow transplants, and the hopes for future applications of both adult and embryonic stem cells, both as a way to model and study disease and a possible treatment for a variety of conditions, such as heart and blood disease, diabetes , Parkinson's, Lou Gehrig's disease, Alzheimer's, spinal cord injuries, and cancer. The uses of federal and private funding for the research are also considered. These issues are discussed by Sir Paul Nurse, president of The Rockefeller University, Doug Melton, Co-director of the Harvard Stem Cell Institute, George Daley of Children's Hospital Boston and the Harvard Stem Cell Institute, Larry Goldstein, director of the UC San Diego Stem Cell program, and Story Landis of the National Institute of Neurological Disorders and Stroke.
|KPBS – Stem Cell Researchers on Ethics and Science 4/5/2007|
Tom Fudge: Stem cells provide some of the greatest hope for curing some of the most devastating diseases. But the promise of stem cells comes with a couple of reservations. First, dramatic cures for diseases like Alzheimer's and Lou Gehrig's disease are still a long way off. Also, the most promising kind of stem cells -- embryonic cells -- are subject to a tremendous amount of ethical controversy. President Bush placed serious restrictions on funding of embryonic stem cell research in 2001. Bipartisan support for more funding in Congress has, so far, failed to overcome the president's veto power.
This afternoon, San Diego's Salk Institute will host a stem cell ethics conference. Joining me to talk about ethics, and stem cells in general, are Larry Goldstein and Laurie Zoloth.
The conference, which is free and open to the public, is sponsored by the Center for Ethics in Science and Technology and the San Diego Research Ethics Consortium. Space is limited and registration is required. Visit http://ethicscenter.net for more details. Read more
|Dr. Goldstein testifies on US Congress about research involving embryonic stem cells 4/26/2000|
Witnesses testified about research involving embryonic stem cells. Among the issues raised were the potential benefits of such research in treating disease, whether to renew federal funding of stem cell research, and the ethical considerations involved in conducting the research.
|AAMC – Stem Cell Research 10/24/1999|
Participants talked about the scientific and moral issues surrounding the use of embryonic stem cell research. They focused on the advances in research that could occur with the use of the stem cells. They also talked about the ethics of using embryonic stem cells and the creation of a public commission to research the issue. After their prepared remarks they answered questions from the audience.