05/21/21. San Diego Chromatin Club. We were fortunate to hear a double feature talks with Dr. Sascha Duttke, UCSD Christopher Benner Group, and Owen Chapman, UCSD Chavez and Mesirov Labs, before our short summer break. Their talks, Decoding Gene Regulation from the Perspective of the Transcription Start Site (TSS) and Extrachromosomal DNA in Medulloblasto, can be heard on YouTube for a limited time.
05/19/21. Center Highlights. We are happy to announce one more publication this month from Center collaborations, Interpreting type 1 diabetes risk with genetics and single-cell epigenomics in Nature. Check it out!
05/17/21. Center Highlights. Our latest publication has been released today in Nature Genetics, CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains, which highlights significant collaborative work from the Funcitional and Spatial Genomics part of the Center. Check it out!
05/14/21. Center Highlights. We are excited to share this publication in Science Advances, Cardiac cell type–specific gene regulatory programs and disease risk association. Check it out!
San Diego Chromatin Club. Dr. Rani George, Dana-Farber Cancer Institute, graciously shared her research in the talk,
Epigenetic remodeling is associated with therapy resistance in cancer.
San Diego Chromatin Club. Thank you Dr. Ashby Morrison for sharing your fascinting research in the talk, Epigenetic regulation of carcinogen susceptibility.
San Diego Chromatin Club. We enjoyed an informative talk, Molecular mechanisms of epigenetic regulation, from Dr. Tatiana Kutateladze. Thank you!
Center Highlights. We are pleased to highlight another 2021 publication in Nature Genetics,
Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk.
San Diego Chromatin Club. Thank you to Dr. Jennifer Cremins for sharing her exciting new research in the seminar, Engineering the repetitive 3D genome in human disease.
San Diego Chromatin Club. We were fortunate to have Dr. Sheila Teves, University of British Columbia, give a fantastic talk,
Transcriptional Memory and Dynamicsin Embryonic Stem Cells.
02/17/21. Center Highlights. Check out our first pre-print of 2021, A cell atlas of chromatin accessibility across 25 adult human tissues.
San Diego Chromatin Club. Dr. Bradley R Cairns, University of Utah, shared his research in a brilliant talk.
San Diego Chromatin Club. Thank you Dr. Paul Wade from the National Institute of Environmental Health Sciences for speaking to our club.
San Diego Chromatin Club. We kicked off our first seminar of 2021 with Dr. Eva Nogales, University of California Berkeley.
12/21/20. Center Highlights. UCSD's tumblr, News of UC San Diego Health Sciences, has featured our SARS-CoV2 publication in a new blog,
A Detailed Look at How SARS-CoV2 Interacts with Lung Cells. Check it out!
11/09/20. Center Highlights. We are proud to share our pre-print is now in press in
eLife, Single cell multiomic profiling of human lung reveals cell type-specific and age-dynamic control of SARS-CoV2 host genes. Check it out!
10/12/20. Center Highlights. Read insights from 4D Nucleosome participants – including our director Dr. Bing Ren – in this Knowable Magazine article,
The blueprint for life, neatly folded, which focuses on the efforts and goals of the 4D Nucleosome program. Check it out!
9/23/20. Center Highlights. Our director Dr. Bing Ren, Center members, and our Functional and Spatial platform were recently mentioned in PNAS in the article Inner Workings: Researchers peek into chromosomes’ 3D structure in unprecedented detail. Check it out!
9/12/20. Center Research. Our newest preprint,
Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk Association is on bioRxiv now!
7/09/20. Center Research. Our newest preprint, CTCF Mediates Dosage and Sequence-context-dependent Transcriptional Insulation through Formation of Local Chromatin Domains is on bioRxiv now!
5/19/20. Center Research. Our newest preprints,
An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum and Single nucleus multiomic profiling reveals age-dynamic regulation of host genes associated with SARS-CoV-2 infection are on bioRxiv now!