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The term "epigenome" refers to the collection of chemical modifications to the DNA and chromatin in the nucleus of a cell, which profoundly influence the functional output of the genome. Epigenome research can provide novel insights into many long-standing questions pertaining to gene regulation and genome function and has the potential to significantly improve our knowledge of human biology and disease.



Our Science

Epigenomics can provide novel insights into many long-standing questions about gene regulation and genome function and can significantly improve our understanding of human biology and disease. Together, this knowledge can lead to breakthrough diagnostic and therapeutic opportunities.

Our mission is to make transformative discoveries which advance science and human health, by applying cutting-edge epigenomic technologies to critical research questions. Learn more...


Our Technology

To make the transformative discoveries that bring us closer to understanding the epigenome in each cell, disease, and individual - we employ state-of-the-art automated platforms for high-throughput epigenomics and single-cell genomics. These platforms enable comprehensive investigation into diverse aspects of the epigenome - and ensure accuracy, reproducibility, and scalability when making these important discoveries. Learn more...


Collaboration

A core part of our mission is to unlock the transformative potential of epigenomics through collaboration. Collaborations with academic and industry partners have the potential to transform our knowledge of the human genome, and to change the paradigm of how we diagnose and treat disease. Learn more...

News

04/01/21. Center Highlights.  We are pleased to highlight another 2021 publication in Nature Genetics, Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk.

03/12/21. San Diego Chromatin Club.  Thank you to Dr. Jennifer Cremins for sharing her exciting new research in the seminar, Engineering the repetitive 3D genome in human disease.

02/26/21. San Diego Chromatin Club.  We were fortunate to have Dr. Sheila Teves, University of British Columbia, give a fantastic talk, Transcriptional Memory and Dynamicsin Embryonic Stem Cells, which is now also on the Center's YouTube for a limited time. 

02/17/21. Center Highlights.  Check out our first pre-print of 2021, A cell atlas of chromatin accessibility across 25 adult human tissues

02/12/21. San Diego Chromatin Club.  Dr. Bradley R Cairns, University of Utah, shared his research in a brilliant talk.

01/29/21. San Diego Chromatin Club.  Thank you Dr. Paul Wade from the National Institute of Environmental Health Sciences for speaking to our club.

01/15/21. San Diego Chromatin Club.  We kicked off our first seminar of 2021 with Dr. Eva Nogales, University of California Berkeley.  

12/21/20. Center Highlights.  UCSD's tumblr, News of UC San Diego Health Sciences, has featured our SARS-CoV2 publication in a new blog, A Detailed Look at How SARS-CoV2 Interacts with Lung Cells. Check it out! 

11/09/20. Center Highlights.  We are proud to share our pre-print is now in press in eLife, Single cell multiomic profiling of human lung reveals cell type-specific and age-dynamic control of SARS-CoV2 host genes. Check it out! 

10/12/20. Center Highlights. Read insights from 4D Nucleosome participants – including our director Dr. Bing Ren – in this Knowable Magazine article, The blueprint for life, neatly folded, which focuses on the efforts and goals of the 4D Nucleosome program. Check it out!

9/23/20. Center Highlights. Our director Dr. Bing Ren, Center members, and our Functional and Spatial platform were recently mentioned in PNAS in the article Inner Workings: Researchers peek into chromosomes’ 3D structure in unprecedented detail. Check it out! 

9/12/20. Center Research. Our newest preprint, Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk Association is on bioRxiv now!

7/09/20. Center Research. Our newest preprint, CTCF Mediates Dosage and Sequence-context-dependent Transcriptional Insulation through Formation of Local Chromatin Domains is on bioRxiv now!

5/19/20. Center Research. Our newest preprints, An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum and Single nucleus multiomic profiling reveals age-dynamic regulation of host genes associated with SARS-CoV-2 infection are on bioRxiv now!

Address

9500 Gilman Drive
MC 0767 
La Jolla, California 92093 -0653

CMM-East
Room #1056-8 (Offices)
Room #1087-88 (Lab)

Contacts

Email: epigenome@ucsd.edu
Phone: 858-246-2650
Twitter: @CEpigenomics