Assay for Transposase-Accessible Chromatin coupled with high-throughput sequencing
How is ATAC-seq useful for my research?
ATAC-seq identifies regions of the genome that have the potential for regulatory activity. These regulatory regions are accessible to the binding of regulatory proteins that influence gene expression, and, thus, also accessible to the transposase enzyme used in ATAC-seq. Identifying regulatory regions can provide valuable insights into the transcriptional regulators and signaling pathways active in a cell type or tissue of interest. For more information please see the following publications:
Buenrostro JD et al. ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. Curr Protoc Mol Biol. 2015 Jan 5;109:21.29.1-9.
Corces MR et al. An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Methods. 2017 Oct;14(10):959-962.
How do I initiate an ATAC-seq project with the Center for Epigenomics?
Typical ATAC-seq projects follow the workflow below which ensures your samples are prepared, submitted, and processed appropriately.
If you are interested in our ATAC-seq Service, please contact us at firstname.lastname@example.org to discuss your ideas.
Looking for specific information about ATAC-seq with the Center?
Room #1056-8 (Offices)
Room #1087-88 (Labs)