The regulated movements of intracellular components along the cellular cytoskeleton, which allows cells to move, divide, communicate with neighboring cells, and maintain cellular homeostasis. Defects in these processes in humans cause neurodegenerative diseases. The Reck-Peterson lab is broadly interested in determining the mechanisms underlying intracellular transport.
Research Focus Areas
Biochemistry and Structural Biology | Membrane Trafficking | Neurodevelopment and Neurodegenerative Disease | Systems Biology
Egan MJ, McClintock MA, Hollyer IH, Elliott HL, Reck-Peterson SL. (2015) Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungi. Cell Reports 11: 201-209.
Toropova K*, Zou S*, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL‡ and Leschziner AE‡. (2014). Lis1 regulates dynein by sterically blocking its mechanochemical cycle. eLife, 3:e03372.
Roberts AJ, Goodman BS, and Reck-Peterson SL. (2014) Reconstitution of dynein transport to the microtubule plus end by kinesin. eLife, 3:e02641.
Derr ND*, Gooman BS*, Jungmann R, Leschziner AE, Shih WM, Reck-Peterson SL. (2012) Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science 338: 662-665.
Highlighted in: Perspective: Diehl MR. (2012). Templating a Molecular Tug-of-War. Science 338: 626-627.
Redwine WB*, Hernarndez-Lopez R*, Zou S, Huang J, Reck-Peterson SL, Leschzniner A. (2012) Structural basis for microtubule binding and release by dynein. Science 337: 1532-1536.
Huang J*, Robert A*, Leschziner L, Reck-Peterson SL. (2012) Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell 150: 975-986.
Highlighted in: Preview: Trokter M and Surrey T. (2012) LIS1 Clamps Dynein to the Microtubule. Cell 150: 877- 879.
Egan M, Tan K, Reck-Peterson SL. (2012) Lis1 is an initiation factor for dynein-driven organelle transport. J Cell Biol., 197: 971-982.
Highlighted in: In this issue: Leslie M. (2012). Lis1 cuts its work short. J Cell Biol 197: 852.
Qiu W*, Derr ND*, Goodman BS, Villa E, Wu D, Shih W, Reck-Peterson SL. (2012) Dynein achieves processive motion using both stochastic and coordinated stepping. Nat Struct Mol Biol 19: 193-201.
Highlighted in: News & Views: Walter W and Diez S. (2012) A staggering giant. Nature 482: 44, 45.
* denotes co-first authorship
** denotes co-second authorship
‡ denotes co-corresponding authorship