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Huilin Zhou, PhD

Professor of Cellular and Molecular Medicine

Contact Information

Office:(858) 534-7808
Lab:(858) 534-0275
Fax:(858) 534-7750

University of California San Diego
Ludwig Institute for Cancer Research
CMM-East, Room 2055
9500 Gilman Drive
La Jolla CA 92093

Lab Website

Gross chromosomal rearrangements (GCRs), including chromosomal translocations, inversions and other rearrangements, are a hallmark of human cancers. The goal of my laboratory is to study the specific signaling pathways, utilizing phosphorylation, sumoylation and ubiquitination that act to maintain genome integrity. We chose Saccharomyces cerevisiae as a model system due to its available genetic assays and because it allows facile biochemical and proteomic studies. Studies in my laboratory have focused on two areas: 1) the DNA damage checkpoint, and 2) protein sumoylation and ubiquitination in genome maintenance. A convergence of genetic, biochemical and proteomic approaches are being pursued to study the molecular mechanisms of signaling pathways that specifically prevent genome rearrangements.


Research Focus Areas:

Biochemistry and Structural Biology  |  Cell Division and Cell Cycle Control  |  DNA Replication and Repair  |  Genetics and Genomics  |  Signal Transduction 


Dr. Zhou's Publications (PubMed)


Selected Publications:

Albuquerque, C. P., Wang, G., Lee, N. S., Kolodner, R. D., Putnam, C. D., and Zhou, H. (2013) Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements. PLoS Genet. 9, e1003670

Chen, S.-H., Albuquerque, C. P., Liang, J., Suhandynata, R. T., and Zhou, H. (2010) A proteome-wide analysis of kinase-substrate network in the DNA damage response. J. Biol. Chem. 285, 12803–12812

Wang, G., Tong, X., Weng, S., and Zhou, H. (2012) Multiple phosphorylation of Rad9 by CDK is required for DNA damage checkpoint activation. Cell Cycle 11, 3792–3800

Chen, S.-H., and Zhou, H. (2009) Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1. J. Biol. Chem. 284, 18593–18604

Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., and Zhou, H. (2008) A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol. Cell Proteomics 7, 1389–1396

Chen, S.-H., Smolka, M. B., and Zhou, H. (2007) Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae. J. Biol. Chem. 282, 986–995

Smolka, M. B., Albuquerque, C. P., Chen, S.-H., and Zhou, H. (2007) Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc. Natl. Acad. Sci. U.S.A. 104, 10364–10369