Christopher K. Glass, MD, PhD

Professor of Cellular and Molecular Medicine
Professor of Medicine

Contact Information

Office: 858-534-6011
Lab: 858-534-8867
Fax: 858-822-2127

University of California, San Diego
Department of Cellular & Molecular Medicine
9500 Gilman Dr., MC 0651

ckg@ucsd.edu 

Lab Website







Dr. Glass’ primary interests are to understand the mechanisms by which sequence-specific transcription factors, co-activators and co-repressors regulate the development and function of macrophages.  A major direction of his laboratory has been to define the genome-wide locations and functions of these proteins through the use of assays that are based on massively parallel DNA sequencing.  The combination of these technologies with molecular, genetic, lipidomic and cell-based approaches is providing new insights into mechanisms that regulate macrophage gene expression and function that are relevant to inflammatory diseases that include diabetes, atherosclerosis and neurodegenerative diseases.

 

Research Focus Areas:

Gene Expression and Regulation  |  Genetics and Genomics  |  Signal Transduction  |  Systems Biology

 

Dr. Glass' Publications (PubMed)

 

Selected Publications:

 

Fonseca GJ, Tao J, Westin EM, Duttke SH, Spann NJ, Strid T, Shen Z, Stender JD, Sakai M, Link VM, Benner C, Glass CK. Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages. Nat Commun. 2019 Jan 24;10(1):414. doi: 10.1038/s41467-018-08236-0. PubMed PMID: 30679424; PubMed Central PMCID: PMC6345992.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 Jun;558(7709):301-306. doi: 10.1038/s41586-018-0198-8. Epub 2018 Jun 6. Erratum in: Nature. 2018 Sep;561(7724):E43. PubMed PMID: 29875409; PubMed Central PMCID: PMC6033669.

Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema MA, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK. Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function. Cell. 2018 Jun 14;173(7):1796-1809.e17. doi: 10.1016/j.cell.2018.04.018. Epub 2018 May 17. PubMed PMID: 29779944; PubMed Central PMCID: PMC6003872.

Muse ED, Yu S, Edillor CR, Tao J, Spann NJ, Troutman TD, Seidman JS, Henke A, Roland JT, Ozeki KA, Thompson BM, McDonald JG, Bahadorani J, Tsimikas S, Grossman TR, Tremblay MS, Glass CK. Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.. Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4680-E4689. doi: 10.1073/pnas.1714518115. Epub 2018 Apr 9. PubMed PMID: 29632203; PubMed Central PMCID: PMC5960280.

Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK. RAn environment-dependent transcriptional network specifies human microglia identity. Science. 2017 Jun 23;356(6344). pii: eaal3222. doi: 10.1126/science.aal3222. Epub 2017 May 25. PubMed PMID: 28546318; PubMed Central PMCID: PMC5858585.

Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK. Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. Elife. 2016 Jul 27;5. pii: e13024. doi: 10.7554/eLife.13024. PubMed PMID: 27462873; PubMed Central PMCID: PMC4963201.

Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, Stender JD, Chun HB, Garner H, Geissmann F, Glass CK. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell. 2014 Dec 4;159(6):1327-40. doi: 10.1016/j.cell.2014.11.023. PubMed PMID: 25480297; PubMed Central PMCID: PMC4364385.