We develop and apply new imaging and viral tools (including spatial transcriptomics and genomics) to understand how gene regulation information propagates across scales from the molecular events within the nucleus to the organization of cells into tissues and organs, up to the scale of animal behavior.
Starting with the nervous system as a model system we are interested in how the sensory neurons regulate the receptor and signaling genes to specialize in both detecting all the different external cues and in transmitting the sensed information to stereotypical projections into the brain.
Research Focus Areas:
Developmental Biology | Genetics and Genomics | Gene Expression and Regulation
Neurodevelopment and Neurodegenerative Disease | Systems Biology
Jun-Han Su, Pu Zheng, Seon S. Kinrot, Bogdan Bintu, Xiaowei Zhuang. Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin Cell, Volume 182, Issue 6, 2020, Pages 1641-1659.e26, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2020.07.032.
B. Bintu, L. Mateo, J. Su, N. Sinnott-Armstrong, M. Parker, S. Kinrot, K. Yamaya, A. Boettiger, X. Zhuang. 2018.
Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells Science (2018) 10.1126/science.aau1783
Y.E. Antebi, J.M. Linton, H. Klumpe, B. Bintu, M. Gong, C. Su, R. McCardell, M. B. Elowitz.
Combinatorial signal perception in the BMP pathway Cell (2017)10.1016/j.cell.2017.08.015
A.N. Boettiger, B. Bintu, J.R. Moffitt, S. Wang, B.J. Beliveau, G. Fudenberg, M. Imakaev, L.A. Mirny, C.T. Wu, X. Zhuang. 2016.
Super-resolution imaging reveals distinct chromatin folding for different epigenetic states Nature (2016) https://doi.org/10.1038/nature16496
S. Wang, J.H. Su, B.J. Beliveau, B. Bintu, J.R. Moffitt, C.T. Wu, X. Zhuang. 2016. Spatial organization of chromatin domains and compartments in single chromosomes Science (2016)10.1126/science.aaf8084