E-mail : email@example.com
My current and future research interests aim to utilize molecular, cellular, and whole animal approaches to understand physiology/pathophysiology in different organ systems. My laboratory utilizes cellular models such as isolated adult rat and mouse cardiac myocytes and neurons to understand the cellular and sub-cellular consequences of various pathophysiologies. These isolated cell systems are more amenable to biochemical and molecular interventions to understand in more sophisticated detail the mechanisms that are at play in disease and can be exploited to elicit protective responses. Ultimately, I use translational models (i.e., transgenic and knockout mice, an intact and ex vivo rat model of ischemia-reperfusion injury, and in vivo pharmacologic studies) to bridge the in vitro biochemical and molecular outcomes to a better understanding of whole organ and animal function. I am interested in how cellular signaling is organized and coordinated in cells and how this is impacted by various disease processes. My laboratory is specifically interested in how membrane microdomains such as caveolae interact and communicate with intracellular organelles such as mitochondria to impact cell, organ, and animal physiology. I hope that this multi level approach to the study of disease will lead to fundamental discoveries related to heart disease, stroke, diabetes, cancer and aging. See website: http://rppresearchgroups.ucsd.edu
References (Selected From 57 Publications)
Patel HH, Murray F, and Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Ann Rev Pharmacol Toxicol. 48: 359-391, 2008.
Patel HH, Tsutsumi YM, and Roth DM. Mito-controversies: Mitochondrial permeability transition pore and myocardial reperfusion injury. Anesthesiology. 108: 182-184, 2008.
Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, and Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and ERK1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 22: 828-840, 2008.
Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, and Insel PA. The cyclic AMP effector Epac integrates pro-and anti-fibrotic signals. Proc Natl Acad Sci USA. 105: 6386-6391, 2008.
Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Roth DM, and Patel HH (co-senior author). Increased expression of caveolin-3 promotes ischemic preconditioning. Circulation. 118:1979-1988, 2008.
Insel PA and Patel HH. Membrane rafts and caveolae in cardiovascular signaling. Curr Opin Nephrol Hypertens. 18: 50-56, 2009.
Patel HH and Insel PA. Lipid rafts and caveolae and their role in compartmentation of redox signaling. Antioxid Redox Signal. 11: 1357-1372, 2009.
Scipta S and Patel HH. Molecular bandages: inside-out, outside-in repair of cellular membranes. Am J Physiol: Cell Physiol, 297: C481-483, 2009. PMCID: PMC2740387
Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, and Patel HH. Role for caveolin-3 and glucose transporter 4 in isoflurane-induced delayed cardiac protection. Anesthesiology. 112: 1136-1145, 2010.
Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase anchoring peptide reduces cardiac function. J Biol Chem. [Epub ahead of print], 2010.