Ilfeld, Brian M.

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My primary research interest involves clinical investigation towards improving perioperative analgesia using regional anesthetic techniques. Towards this end, I earned a Masters Degree of Medical Sciences in Clinical Investigation (supported by an NIH K30 award). Following this, I acquired a Mentored Research Training Grant from the Foundation of Anesthesia Education and Research and a K23 Mentored Career Development Award from the National Institutes of Health.  The goals of this research were to determine the relationship between ambulatory continuous peripheral nerve blocks and various clinically-relevant postoperative endpoints following total joint arthroplasty. Towards this end, I assembled and direct the PAINfRE group of investigator(<> which design and implement multicenter clinical trials involving ambulatory perineural local anesthetic infusion.  I currently serve as the Chair for Clinical Research for the Division of Regional Anesthesia, and currently manage 8 open IRB-approved clinical studies as well as mentor regional anesthesia fellows and junior faculty

References (Selected From 59 Publications)

Mariano ER, Loland VJ, Sandhu NS, Bishop ML, Lee DK, Schwartz AK, Girard PJ, Ferguson EJ, Ilfeld BM.Comparative efficacy of ultrasound-guided and stimulating popliteal-sciatic perineural catheters for postoperative analgesia. Can J Anaesth. 2010 Aug 11.

Ilfeld BM, Mariano ER, Girard PJ, Loland VJ, Meyer RS, Donovan JF, Pugh GA, Le LT, Sessler DI, Shuster JJ, Theriaque DW, Ball ST.A multicenter, randomized, triple-masked, placebo-controlled trial of the effect of ambulatory continuous femoral nerve blocks on discharge-readiness following total knee arthroplasty in patients on general orthopaedic wards.Pain. 2010 Sep;150(3):477-84. Epub 2010 Jun 22.

Ilfeld BM, Loland VJ, Mariano ER.Prepuncture ultrasound imaging to predict transverse process and lumbar plexus depth for psoas compartment block and perineural catheter insertion: a prospective, observational study.Anesth Analg. 2010 Jun 1;110(6):1725-8.

Ilfeld BM, Fredrickson MJ, Mariano ER. Ultrasound-guided perineural catheter insertion: three approaches but few illuminating data.Reg Anesth Pain Med. 2010 Mar Apr;35(2):123-6.

Mariano ER, Loland VJ, Sandhu NS, Bishop ML, Meunier MJ, Afra R, Ferguson EJ, Ilfeld BM.A trainee-based randomized comparison of stimulating interscalene perineural catheters with a new technique using ultrasound guidance alone.J Ultrasound Med;29:329-36.20101

Ilfeld BM, Moeller LK, Mariano ER, Loland VJ, Stevens-Lapsley JE, Fleisher AS, Girard PJ, Donohue MC, Ferguson EJ, Ball ST Continuous peripheral nerve blocks: is local anesthetic dose the only factor, or do concentration and volume influence infusion effects as well?Anesthesiology. 2010 Feb;112(2):347-54.

Ilfeld BM, Le LT, Ramjohn J, Loland VJ, Wadhwa AN, Gerancher JC, Renehan EM, Sessler DI, Shuster JJ, Theriaque DW, Maldonado RC, Mariano ER.  Effects of local anesthetic concentration and dose on continuous infraclavicular nerve blocks: A multi-center, randomized, observer-masked, controlled study.  Anesth Analg 2009; 108: 245-50

Ilfeld BM, Meyer RS, Le LT, Mariano ER, Williams BA, Vandenborne K, Duncan PW, Sessler DI, Enneking FK, Shuster JJ, Maldonado RC, Gearen PF. Health-related quality-of-life following tricompartment knee arthroplasty with and without an extended-duration continuous femoral nerve block:  a prospective, one-year follow-up of a randomized, triple-masked, placebo-controlled study. Anesth Analg 2009; 108: 1320-5.