Chitra Mandyam


Our laboratory incorporates innovative experiments to elucidate important issues that are of high importance to the addiction and adult neurogenesis fields. The general goal of our laboratory is to understand the relationship between brain structure and function using state-of-the-art molecular and cellular approaches to study high-level mental functions such as drug taking and seeking (which are the purview of behavioral and cognitive neuroscience). We employ genetic, pharmacological and histochemical techniques, and behavioral paradigms for understanding the role of newly born neurons and myelinating oligodendrocytes in drug pathology. The specific research theme of our laboratory is to determine the functional significance of adult neurogenesis and gliogenesis in addiction and addictive disorders. Our research is focused around two areas of inquiry:1) the role of stem cells in drug neuropathology and 2) novel neuroprotective strategies in addictive disorders.

Key words: Substance Use Disorders, Alcohol Use Disorders, Adult neurogenesis, prefrontal cortex, hippocampus, methamphetamine, alcohol, self-administration, rodent model