Facilities and Equipment 4000MRS
The MRSolutions 4000MRS Preclinical MRI is located in the IVISR at the Moores Cancer Center. Capable of fild strengths of up to 4.7T the system is ideal for high definition images of soft tissues.The tight shielding of the magnet allows for a very small fringe field, increasing safety while improving image quality and machine flexibility. With integrated anesthesia and animal monitoring systems, this magnet is ideal for rapid soft tissue imaging, contrast enhanced dynamic scans, longer scans of in vitro or post mortem samples and everything in between.
MRI is the optimum imaging modality for soft tissues, and compliments the capabilities of CT and PET to image harder structures and radiolabeled tracers respectively. It is ideal for finding and measuring soft tumors or other organs, and when combined with contrast, can also image the uptake of some experimental agents. With a wide assortment of different scan types, both T1 and T2 weighted, images can be collected to reveal both anatomy and physiology. Repeated longitudinal scans can explore the development of disease states and lesions, as well as potentially indicate response to treatment.
- High resolution images of soft tissues, with arbitrary slice orientation
- Measurement of tumor burden with and without contrast
- Contrast development
- Dynamic scans indicating agent uptake and distribution
- Real time animal monitoring
- Anatomic Imaging
MR imaging will be performed in high resolution to provide anatomic landmarks to co-localize signals acquired with PET, gamma camera, or optical imaging.
- Development of MR based contrast media
We currently use Multihance, a T1 contrast agent, as our main contrast agent. It is a widely available and used in clinics worldwide. If your needs require alternate contrast methods, we can help in the research and acquisition of the appropriate agents.